Infectious pulmonary disease in patients receiving immunosuppressive therapy for organ transplantation

Diabetes mellitus in pediatric solid organ recipients without and with cystic fibrosis: An analysis from the German-Austrian diabetes database (Diabetes Patienten Verlaufsdokumentation)

“…Posttransplantation diabetes mellitus (PTDM) was first described over 45 years ago as a complication of renal transplantation attributable to steroid use. 1,2 It has since become clear that PTDM is not an uncommon complication after solid organ transplantation (SOT) and that it promotes cardiovascular disease, graft failure, and death. 3 The cardiovascular risk associated with prediabetes and diabetes has been underappreciated in SOT.…”

From PERV to CRISPR

“…Our first disruptive technology is xenotransplantation. Starting with a long history of dramatic anecdotal attempts to transplant primate organs into humans, the approach matured into the possibility of using pigs as donor animals . The size of porcine organs and their similar physiology to humans suggested that they might be suitable, although how well the organs would respond to the multiple hormonal regulatory pathways that control function during life remains to be defined.…”