Infectious pancreatic necrosis virus suppresses type I interferon signalling in rainbow trout gonad cell line but not in Atlantic salmon macrophages

A recombinant CHSE-214 cell line expressing an Mx1 promoter–reporter system responds to both interferon type I and type II from salmonids and represents a versatile tool to study the IFN-system in teleost fish

“…Studies are in progress to find out if the lack of activation of the Mx promoter is a specific effect on an IFN-responsive promoter or is a general consequence of virus infection on the activation of cellular genes. The present results concerning IPNV are in agreement with RTG-P1 studies where, at high multiplicities of infection, IPNV blocked poly(I:C)-induced IFN activity [41].…”

Biological characterisation of a recombinant Atlantic salmon type I interferon synthesized in Escherichia coli

“…However, a direct comparison of the known SasaIFN-a subtypes may help elucidate any differential biological activities for a more complete representation of the Atlantic salmon IFN system. Certain viruses, such as IPNV and ISAV, can evade the fish immune system by inhibiting early expression of IFN in the critical phases of infection [24,38]. For IPNV infections, treatment with rSasaIFN-a1 resulted in cellular protection, in part by the IFN-induced Mx1 protein [39].…”

Teleost TLR22 Recognizes RNA Duplex to Induce IFN and Protect Cells from Birnaviruses

“…Because fgTLR22 induced IFN in fish cells, we expected it to be required for cell protection against virus infection. To test this hypothesis, we prepared dsRNA of the IPNV (38,39). IPNV genomic dsRNA was extracted from IPNV-infected RTG-2 cells.…”