Infectious morbidity and resource use in children under 2 years old at childcare centres

Castillo-Aguas, Guadalupe del; Gallego-Iborra, Ana; Gutiérrez-Olid, Mario; Pérez-González, Olga; Moreno-Muñoz, Ginesa; Ledesma-Albarrán, Juana M

doi:10.1111/jpc.13372

Cited by 9 publications

(3 citation statements)

References 27 publications

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“…Here, infants were followed-up from 1 to 6 months, compared to the other two studies in which the infants were in the study from 6 to 12 months ( 22 ) and from 1 to 12 months of age ( 24 ). This observation is in agreement with other studies ( 35 ), and could be explained by several factors, including the fact that infants that may attend day care centers in Spain—a major risk factor for infection in infants ( 36 – 38 )—are normally older than 6 months of age ( 38 ).…”

Section: Discussionsupporting

confidence: 93%

Beneficial Effects of Limosilactobacillus fermentum CECT 5716 Administration to Infants Delivered by Cesarean Section

Blanco-Rojo

Maldonado

Schaubeck³

et al. 2022

Front. Pediatr.

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Cesarean section (CS) disrupts the natural microbiota colonization process in infants, which might compromise immune system maturation, leading to a higher risk of infections. We evaluated the effect of the probiotic Limosilactobacillus (L.) fermentum CECT 5716 on the incidence of gastrointestinal and respiratory infections in the CS infant subgroups (n = 173) of three randomized clinical trials in which this probiotic strain was demonstrated to be safe and effective for preventing infections. Therefore, the data for the CS infants were extracted to obtain the incidence rate ratio (IRR) and 95% CI for gastrointestinal and respiratory infections for each study and were then combined to obtain a pooled IRR and 95% CI using the generic inverse variance method. There was a significant reduction of 73% in the incidence of gastrointestinal infections in CS infants receiving L. fermentum CECT 5716 compared with those receiving the control formula [n = 173, IRR: 0.27 (0.13, 0.53), p = 0.0002]. Regarding respiratory infections, although pooled results showed a reduction of 14% in the probiotic group, the difference was not statistically significant [n = 173, IRR (95% CI): 0.86 (0.67, 1.11), p = 0.25]. In conclusion, the administration of L. fermentum CECT 5716 to CS-born infants protects them from gastrointestinal infections by reducing the risk by up to 73% in this population.

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Section: Discussionsupporting

confidence: 93%

Beneficial Effects of Limosilactobacillus fermentum CECT 5716 Administration to Infants Delivered by Cesarean Section

Blanco-Rojo

Maldonado

Schaubeck³

et al. 2022

Front. Pediatr.

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“…Attending nursery has been associated with a greater frequency of recurring infections and wheezing, as well as consumption of antibiotics, bronchodilators, and anti-inflammatories. 18,19 The low incidence of infectious diseases in both groups does not seem to be noteworthy. The age at which they began to attend nursery was similar; however, "upon request" consultations due to illness was relatively low in both groups (three to four visits/year) compared to a national morbidity study for the same age group during the same time period (nine to ten visits/year).…”

Section: Resultsmentioning

confidence: 83%

Effects of the affinity to the Mediterranean diet pattern together with breastfeeding on the incidence of childhood asthma and other inflammatory and recurrent diseases

Calatayud-Sáez¹,

Calatayud²,

Luque³

et al. 2021

aei

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Introduction: There is an increasing amount of data relating the dietetic pattern to health variables, although data concerning the child population are scarce. The aim of the study was to assess the effects of affinity to the Traditional Mediterranean Diet (TMD) pattern, together with breastfeeding, on the incidence of childhood asthma and other inflammatory and recurrent diseases (IRD) in children under 2 years of age. Methods: Single-group intervention study evaluating differences in results according to degree of adherence to TMD recommendations. According to their adhesion to the TMD-Breastfed Test, patients were classified into two groups: Group 1 (with greater adherence) and Group 2 (with less adherence). The incidence of childhood asthma and IRD was evaluated and com-pared with both groups. Results: The score of the TMD-Breastfed Test was optimal in Group 1 and good in Group 2. It shows a marked reduction in both consultation groups “on request” compared with “planned,” with low morbidity and low use of antibiotics. The incidence of infectious diseases and recurrent bacterial complications shows a clinically relevant difference between both groups. The incidence of childhood asthma was greater and statistically significant in Group 2, with less adherence to breastfeeding. Conclusions: In these cohorts of breastfed patients with good adherence to TMD patterns, there was evidence of a low incidence of childhood asthma and the IRD, more pronounced in the highest adherence Group 1. Some non-TMD foods have been linked to the occurrence of childhood asthma and IRD, as their dietary limitations have contributed to decreasing morbidity.

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“…This indicates that TMD, in addition to protecting the defensive system, can promote the establishment of an adequate metabolism [ 26 ]. Infant asthma (RW) in the subgroup that left breastfeeding early had an incidence similar to the national database (15%) [ 27 ]. In this group, the rest of the TMD completion parameters were similar, which makes us suspect that adapted cow’s milk could be closely related to the development of bronchial hyper-reactivity and, therefore, breastfeeding could offer important protection [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of the Mediterranean Diet on Morbidity from Inflammatory and Recurrent Diseases with Special Reference to Childhood Asthma

Calatayud-Sáez¹,

Calatayud²,

Calatayud³

2022

Nutrients

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Objective: For 15 years, we have been working with a nutritional programme based on the traditional Mediterranean diet (TMD) to complete the treatment of inflammatory and recurrent diseases (IRD), such as childhood asthma. The objective of this study is to verify the effects of TMD in the prevention and treatment of IRD by measuring the incidence of infant morbidity over 8 years. Material and Methods: The number of patients who suffered from IRD each year (just before the pandemic) was determined, as well as the frequentation and the percentage of scheduled and on-demand consultations. Results: The incidence of infant morbidity decreased as they were incorporated into a TMD, and we observed a progressive disappearance of IRD. At the beginning of the study, 20% of the patients had been diagnosed with some type of IRD. At the study’s end, the prevalence of IRD decreased to less than 2%, and the use of drugs and surgical interventions decreased markedly. Conclusions: A diet based on the TMD reduces the incidence of infant morbidity and contributes to the disappearance of IRD, whereas some non-traditional foods with high antigenic power could be involved in the appearance of IRD.

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Infectious morbidity and resource use in children under 2 years old at childcare centres

Abstract: Attending a childcare is associated with an increased frequency of recurrent infections and wheezing, as well as the consumption of antibiotics, bronchodilators, corticosteroids and montelukast.

Cited by 9 publications

References 27 publications

Beneficial Effects of Limosilactobacillus fermentum CECT 5716 Administration to Infants Delivered by Cesarean Section

Beneficial Effects of Limosilactobacillus fermentum CECT 5716 Administration to Infants Delivered by Cesarean Section

Effects of the affinity to the Mediterranean diet pattern together with breastfeeding on the incidence of childhood asthma and other inflammatory and recurrent diseases

Effects of the Mediterranean Diet on Morbidity from Inflammatory and Recurrent Diseases with Special Reference to Childhood Asthma

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