Infectious Mononucleosis With Penile Ulceration

Kallos, Andrew

doi:10.1001/archderm.1954.01540170088015

Cited by 4 publications

(3 citation statements)

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“…Males can also be affected, although more rarely, by Lipschütz's genital ulcers in the form of scrotal or penile ulcers. 120,121 There are limitations and strengths that should be noted when reading this communication.…”

Section: Discussionmentioning

confidence: 99%

Lipschütz’s acute vulvar ulcer: a systematic review

et al. 2020

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In previously healthy subjects, vulvar ulcers are mostly caused by sexually transmitted microorganisms. Lipschütz's acute vulvar ulceration, first reported in 1912, is a non-sexually acquired condition characterized by sudden onset of a few genital ulcers. We systematically review presentation, underlying causes and disease duration of Lipschütz's ulceration.Comprehensive source of Excerpta Medica, National Library of Medicine and Web of Science databases was performed. Reports including cases of apparently previously healthy females affected by Lipschütz's ulceration were selected a predefined database was used to extract data on demographics, history, clinical and microbiological findings, and treatment.The search disclosed 158 cases. Almost 90% of cases were ≤20 years of age and sexually inactive. Lesions were usually one to about three, painful, ≥10 mm large, well-delimited, with a fibrinous and necrotic center and a symmetric distribution. Voiding disorders and enlarged inguinal lymph nodes were observed in a large subset of cases. Canker sores were noted in 10% of patients. Lipschütz's vulvar ulceration occurred concomitantly with an infectious disease in 139 cases. Infectious mononucleosis syndrome (N=40) was the most frequently detected well-defined infection, followed by mycoplasma species infections (N=11). The disease resolved after ≤3 weeks. CONCLUSIONS: Lipschütz's ulceration mainly affects both sexually inactive and, less frequently, sexually active subjects ≤20 years of age, presents with ≤3 vulvar ulcers, resolves without recurrences within 3 weeks and is temporarily associated with an infection, most frequently a flu-like illness or an infectious mononucleosis syndrome.

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Section: Discussionmentioning

confidence: 99%

Lipschütz’s acute vulvar ulcer: a systematic review

et al. 2020

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“…We found 264 studies related to the possible cutaneous and mucosal manifestations during EBV acute infection; we selected the articles that more exhaustively reported the clinical and laboratory description of the case/cases, 5‐45 published from 1954 to 2018 (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Dermatological manifestations of Epstein‐Barr virus systemic infection: a case report and literature review

et al. 2020

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Epstein-Barr virus (EBV) is a human herpesvirus spread in childhood by contact with saliva. In all populations, the great majority of people are infected by middle age. EBV can cause asymptomatic infection, nonspecific symptoms or, especially in adolescents and young adults, the infectious mononucleosis (IM), characterized by pharyngitis, lymphadenopathy, fatigue, and fever. Two main types of skin rashes, accounted as atypical exanthems, occur in patients with acute IM: a faint erythematous maculopapular eruption of 24-48 hours duration (5-15% of the patients) or a pruritic maculopapular rash in almost all patients receiving ampicillin or amoxicillin. Moreover EBV acute infection has been related to other cutaneous manifestations, such as Gianotti-Crosti syndrome, unilateral laterothoracic exanthem (especially in children), and others. In this study, we reported a case of atypical exanthem with an erythematous-papulovesicular pattern in a 22-year-old female patient with IM and performed a review of the literature of the cutaneous and mucosal eruptions occurring during EBV acute infections.

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“…Painful penile ulceration associated with primary EBV infection has rarely been described since 1950s . With fever, enlarged inguinal lymph nodes and highly positive heterophile antibody test, the ulcers were described to be the initiating sign of primary EBV infection before progression to generalized lymphadenopathy involving typically the cervical and axillary lymph nodes.…”

Section: Juvenile Gangrenous Vasculitis Of the Scrotummentioning

confidence: 99%

Lipschütz genital ulcer revisited: is juvenile gangrenous vasculitis of the scrotum the male counterpart?

Chen

Plewig

2019

Acad Dermatol Venereol

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Since its first description as ulcus vulvae acutum by Benjamin Lipschütz in 1912, the etiopathogenesis of this peculiar genital ulcer remains incompletely understood. In his original description, two different types of genital ulcers were observed and proposed, which were not precisely defined and distinguished in most subsequent reports. The first type is characterized by acute excruciating genital ulcers of first‐time onset with self‐limited non‐recurrent course in association with gravely symptomatic systemic infections, in which a primary Epstein–Barr virus (EBV) infection is later identified to be probably the most common aetiology. The second type of ulcer usually refers to little painful ulcers of unknown etiopathogenesis in the absence of fever or chills and with a slow torpid progression and recurrent nature. Differentiation from idiopathic aphthous ulcers is unclear. The changes of the cervicovaginal microbiota and microbiome in diseased state deserve further clarification. Acute genital ulcers associated with primary EBV infection in women have drawn attention since 1970s, while the corresponding penile ulcers in men were already known in 1950s. First presented in 1973, juvenile gangrenous vasculitis of the scrotum with an acute painful scrotal ulcer preceded by symptomatic pharyngeal infections can be considered as the male counterpart of ulcus vulvae acutum, and the future clinical survey should include primary EBV infection.

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Infectious Mononucleosis With Penile Ulceration

Cited by 4 publications

References 0 publications

Lipschütz’s acute vulvar ulcer: a systematic review

Lipschütz’s acute vulvar ulcer: a systematic review

Dermatological manifestations of Epstein‐Barr virus systemic infection: a case report and literature review

Lipschütz genital ulcer revisited: is juvenile gangrenous vasculitis of the scrotum the male counterpart?

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