Infectious Mononucleosis Followed by Hodgkin's Disease

Hodgkin's disease following infectious mononucleosis

“…In cases of acute lymophocytic leukaemia described by Levine et al (1972) and the case of Hodgkin's described by English (1970), Epstein-Barr antibodies were demonstrated, and these antibodies have been shown to be distinct from the heterophil antibody measured in the Paul Bunnell reaction.…”

“…In their first case acute lymphocytic leukaemia was diagnosed 15 months after the initial infection and the patient presented as a 'recurrent' infectious mononucleosis and the other two cases developed acute lymphocytic leukaemia concurrently with infectious mononucleosis. The case of Hodgkin's disease described by English (1970) occurred 7 months after infectious mononucleosis and the slide test was negative at the time of the diagnosis of Hodgkin's disease.…”

Antibodies to Epstein-Barr and other viruses in children with acute lymphoblastic leukaemia

“…It has also been detected in leukaemic cells (Hehlmann, Kufe, and Spiegelman, 1972b) and antigenic relations have been observed (Mann, Halterman, and Leventhal, 1973) between acute leukaemic cells and cells infected with Rauscher leukaemia virus. Patients with infectious mononucleosis have been known to develop Hodgkin's disease (English, 1970), Burkitt's lymphoma (Cohen et al, 1970), and acute leukaemia (Levine et al, 1972).…”

The EB virus in relation to infectious mononucleosis

“…These observations chime well with our present knowledge linking the EB virus with Burkitt's lymphoma and with nasopharyngeal carcinoma, and the connexion with infectious mononucleosis is thought-provoking. Clinical infectious mononucleosis bears no patent relationship with malignant disease although, rarely, it may be followed by Burkitt's tumour (Cohen, Hirshaut, Stevens, Hull, Davis, and Carbone, 1970) or by Hodgkin's disease (English, 1970 virus antibody titres have been observed (Levine, Ablashi, Berard, Carbone, and Waggoner, 1970;Johansson, Klein, Henle, and Henle, 1970) and Reed-Sternberg-like cells have been observed in infectious mononucleosis (Lukes, Tindle, and Parker, 1969;McMahon, Gordon, and Rosen, 1970) Although there has been speculation that infectious mononucleosis is 'an atypical form of acute leukaemia with a self-limiting course' (Dameshek and Gunz, 1964), EB virus studies have not supported this and concurrent infectious mononucleosis and acute leukaemia is not uncommon (Lampkin, Canales and Mauer, 1967;Deardorff, Gerber, and Vogler, 1970;Ragab and Vietti, 1969;Stevens, Levine, Lee, Sonley, and Waggoner, 1971).…”