Infectious Mononucleosis Epidemiology and Pathogenesis

Straus, Stephen E.; Fleisher, Gary R.

doi:10.1007/978-1-4684-6376-7_2

Cited by 11 publications

(3 citation statements)

References 104 publications

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“…The prevalence of mononucleosis in the general population ranges from 0.0002% to 0.005%, [28][29][30] which differs significantly from the incidence of mononucleosis in the population with PCS (P , .001), suggesting that mononucleosis may be a risk factor for PCS. In addition, 5.8% of patients in the study had a Chiari malformation, which is significantly greater than the prevalence of 0.00078% in the general population (P = 0).…”

Section: Discussionmentioning

confidence: 91%

The Postconcussion Syndrome in Sports and Recreation

Tator

Davis

2014

Neurosurgery

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Section: Discussionmentioning

confidence: 91%

The Postconcussion Syndrome in Sports and Recreation

Tator

Davis

2014

Neurosurgery

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“…While benign and asymptomatic for the most part, EBV infection has the potential to cause many nonmalignant and malignant diseases of lymphoid and epithelial origins (2). EBV infection during childhood is mostly asymptomatic; however, primary exposure during adolescence manifests itself as infectious mononucleosis (IM) in 30 to 70% of cases (3)(4)(5)(6)(7). It is not known why some individuals are more likely than others to develop clinical symptoms from delayed infection (8).…”

mentioning

confidence: 99%

Impaired Epstein-Barr Virus-Specific Neutralizing Antibody Response during Acute Infectious Mononucleosis Is Coincident with Global B-Cell Dysfunction

Panikkar

Smith

Hislop

et al. 2015

J Virol

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Here we present evidence for previously unappreciated B-cell immune dysregulation during acute Epstein-Barr virus (EBV)-associated infectious mononucleosis (IM). Longitudinal analyses revealed that patients with acute IM have undetectable EBV-specific neutralizing antibodies and gp350-specific B-cell responses, which were associated with a significant reduction in memory B cells and no evidence of circulating antibody-secreting cells. These observations correlate with dysregulation of tumor necrosis factor family members BAFF and APRIL and increased expression of FAS on circulating B cells.

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“…Therefore, a number of primary EBV infections are clinically silent or atypical. The classic triad of symptoms of acute infectious mononucleosis-fever, pharyngitis, and lym-phadenopathy-is well known, but infectious mononucleosis often displays atypical presentations that are difficult to diagnose [1,3,4]. Among 17 infants with serological evidence of current or recent primary EBV infection, none developed signs or symptoms that were suggestive of acute infectious mononucleosis [5].…”

mentioning

confidence: 99%

Diagnosis of Atypical Cases of Infectious Mononucleosis

Taga

Taga²,

Tosato

2001

CLIN INFECT DIS

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The variable manifestations of infectious mononucleosis rarely cause clinicians to suspect primary Epstein-Barr virus or cytomegalovirus infection; consequently, costly diagnostic tests and unnecessary treatments are undertaken. Seventeen cases of clinically atypical and 11 cases of clinically typical infectious mononucleosis were diagnosed through screening for atypical and apoptotic lymphocytes in the peripheral blood samples by means of an automated hematologic analyzer. Atypical and typical cases did not differ significantly with respect to peripheral white blood cell counts; percentages of lymphocytes, atypical lymphocytes, CD4(+) lymphocytes, human leukocyte antigen--DR positivity in CD3 lymphocytes, or apoptotic cells in blood smear after incubation; or levels of aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase. Only the percentage of CD8(+) lymphocytes was significantly higher in patients with typical infectious mononucleosis than it was in patients with atypical infectious mononucleosis. Because certain atypical cases of infectious mononucleosis display laboratory abnormalities that are characteristic of typical infectious mononucleosis, enhanced awareness can help in the diagnosis.

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Infectious Mononucleosis Epidemiology and Pathogenesis

Cited by 11 publications

References 104 publications

The Postconcussion Syndrome in Sports and Recreation

The Postconcussion Syndrome in Sports and Recreation

Impaired Epstein-Barr Virus-Specific Neutralizing Antibody Response during Acute Infectious Mononucleosis Is Coincident with Global B-Cell Dysfunction

Diagnosis of Atypical Cases of Infectious Mononucleosis

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