Infectious Mononucleosis: Epidemiologic Patterns at United States Colleges and Universities1

Brodsky, Alan L.; Heath, Clark W.

doi:10.1093/oxfordjournals.aje.a121444

Cited by 39 publications

(17 citation statements)

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“…The virus can also be transmitted by blood transfusion, but this mode is rare. Furthermore, earlier reports from US colleges and universities did not describe a definite seasonal pattern for IM [12], in a more recent previous study of the clinical, laboratory, and seasonality patterns of IM in the same target population as the present one, though for a period of only 4 years (total, 590 patients), our group clearly demonstrated a strong tendency for the warmer months of the year [5]. Together with the present largerscale study, these findings [5,10,11] support recent biological and epidemiological studies suggesting that EBV may be considered a sexually transmitted disease, at least among young adults [6][7][8].…”

Section: Discussionmentioning

confidence: 73%

Secular and seasonal trends of infectious mononucleosis among young adults in Israel: 1978–2009

Levine

Mimouni

Grotto

et al. 2011

Eur J Clin Microbiol Infect Dis

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Recent evidence that infectious mononucleosis (IM) may be sexually transmitted prompted the present analysis. Infectious mononucleosis is a notifiable disease in the Israel Defense Forces (IDF). For the present study, the archives of the IDF were reviewed for all cases of IM from January 1, 1978 to December 31, 2009, and the rates were calculated. Annual rates decreased from 2.99 cases per 1,000 in 1979 to a low of 0.38 cases per 1,000 young adults in 1987. Between 2002 and 2009, the average annual rate was 0.88 cases per 1,000, just half the average rate of 1.69 observed between 1989 and 2001. Average monthly rates varied from a low of 0.90 cases per 10,000 in February to a high of 1.50 cases per 10,000 in August. The difference in the average rates between winter (1.02 cases per 10,000 soldiers) and summer (1.29 cases per 10,000 soldiers) was significant (p < 0.01). Analysis of the long-term epidemiology of IM shows that the infection rate has varied over time, and that the disease is more prevalent in the warmer months. This seasonality trend was also observed in several STD, raising the possibility of considering this mode of transmission in IM.

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Section: Discussionmentioning

confidence: 73%

Secular and seasonal trends of infectious mononucleosis among young adults in Israel: 1978–2009

Levine

Mimouni

Grotto

et al. 2011

Eur J Clin Microbiol Infect Dis

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“…No clear-cut seasonal pattern for infectious mononucleosis has been recognized (30,77). However, more cases have been documented among U.S. college and university students when school is in session than during semester breaks (30), and Leard observed over a 12-year period that there was an October peak in admissions for infectious mononucleosis to the Boston University infirmary (120).…”

Section: Epidemiologymentioning

confidence: 99%

“…However, more cases have been documented among U.S. college and university students when school is in session than during semester breaks (30), and Leard observed over a 12-year period that there was an October peak in admissions for infectious mononucleosis to the Boston University infirmary (120). A peak incidence during June to August was reported among patients in the Israeli Defense Force (67), which the authors ascribed to increased socializing of young people during the summer.…”

Section: Epidemiologymentioning

confidence: 99%

Progress and Problems in Understanding and Managing Primary Epstein-Barr Virus Infections

2011

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SUMMARY Epstein-Barr virus (EBV) is a gammaherpesvirus that infects a large fraction of the human population. Primary infection is often asymptomatic but results in lifelong infection, which is kept in check by the host immune system. In some cases, primary infection can result in infectious mononucleosis. Furthermore, when host-virus balance is not achieved, the virus can drive potentially lethal lymphoproliferation and lymphomagenesis. In this review, we describe the biology of EBV and the host immune response. We review the diagnosis of EBV infection and discuss the characteristics and pathogenesis of infectious mononucleosis. These topics are approached in the context of developing therapeutic and preventative strategies.

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“…(1) No heterophile-positive infectious mononucleosis was diagnosed among the students at the Chinese University of Hong Kong from July 1986 to May 1988. (2) In May 1988, we retested the 10 students whose EBV antibody status was negative or unknown in September 1986; 1 has seroconverted.'…”

Section: Notementioning

confidence: 99%

Epstein-Barr Virus Infections among University Students in a Tropical Country

Chang

Dán

Chan

1988

Journal of American College Health

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Infectious Mononucleosis: Epidemiologic Patterns at United States Colleges and Universities1

Cited by 39 publications

References 0 publications

Secular and seasonal trends of infectious mononucleosis among young adults in Israel: 1978–2009

Secular and seasonal trends of infectious mononucleosis among young adults in Israel: 1978–2009

Progress and Problems in Understanding and Managing Primary Epstein-Barr Virus Infections

Epstein-Barr Virus Infections among University Students in a Tropical Country

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