Infectious Keratitis in Climatic Droplet Keratopathy

Sridhar, M. S.; Garg, Prashant; Das, Sujatha; Vemuganti, Geeta K.; Gopinathan, Usha; Rao, Gullapalli N

doi:10.1097/00003226-200007000-00009

Cited by 6 publications

(7 citation statements)

References 10 publications

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“…The cornea is at risk of infection when there is disruption of the defense mechanisms, which can be due to various local and systemic factors (Table 1) [5][6][7][8][9][10][11][12][13]. A systematic approach of infective keratitis in a patient (Fig.…”

Section: Risk Factors For Infective Keratitismentioning

confidence: 99%

Pearls and paradigms in Infective Keratitis

Acharya¹,

Farooqui²,

Jain³

et al. 2019

rjo

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Infective Keratitis is a commonly encountered sight-threatening ocular emergency. In developing countries, it is a major cause of corneal blindness. Empirical treatment without microbiological work up often leads to treatment failure. Indiscriminate use of steroid antibiotic combination worsens the situation and makes further management challenging. The correct line of management can be potentially sight saving for both the ophthalmologist and the patient. This article on Infective keratitis has been written keeping best practices and protocols in mind. In a very simple and concise form, it focuses on the salient features of clinical presentation of infective keratitis and the stepwise approach to subsequent management in a patient. It explains in detail the way to perform corneal scraping, the importance of the same and further management based on microbiologically proven result. The management part includes indications and methods for medical as well as surgical intervention. We aimed to share our experience in the management of patients presenting with infective keratitis in the clinic.

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Section: Risk Factors For Infective Keratitismentioning

confidence: 99%

Pearls and paradigms in Infective Keratitis

Acharya¹,

Farooqui²,

Jain³

et al. 2019

rjo

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“…The irregularity affects the vision, and causes repeated epithelial breakdowns resulting in pain and photophobia, and predisposes the cornea to infections. [24] Sridhar et al ., have reported the proximity of an infiltrate close to the spherules, necessitating treatment, irrespective of their location. [24] The management options include superficial keratectomy (manual or laser), with or without amniotic membrane grafts (AMG).…”

Section: Therapeutic Indications [Table 1]mentioning

confidence: 99%

“…[24] Sridhar et al ., have reported the proximity of an infiltrate close to the spherules, necessitating treatment, irrespective of their location. [24] The management options include superficial keratectomy (manual or laser), with or without amniotic membrane grafts (AMG). [12325] LKP or penetrating keratoplasty (PKP) may be required for deeper involvement.…”

Section: Therapeutic Indications [Table 1]mentioning

confidence: 99%

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Phototherapeutic keratectomy

Rathi

Vyas

Sangwan

2012

Indian J Ophthalmol

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Phototherapeutic keratectomy (PTK) is done regularly for anterior corneal diseases such as corneal dystrophies, corneal degenerations, scars, and band-shaped keratopathy. The various indications include both therapeutic and visual. The aim of this article is to discuss the therapeutic indications for PTK, the specific technique pertaining to a specific etiology, the various other procedures like amniotic membrane graft combined with PTK or PTK being done for recurrences in the grafts, and PTK done before cataract surgery when the anterior corneal pathology coexists with the cataract. Post PTK management such as healing of an epithelial defect, use of steroids in the post PTK period, recurrences of primary disease pathology, and infections, will be discussed. Methods of literature search: A Medline search was carried out for articles in the English language, with the keywords, phototherapeutic keratectomy, band-shaped keratopathy, spheroidal degeneration, scars, bullous keratopathy, and corneal dystrophy. The relevant references are mentioned here.

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“…Sequels of corneal perforations were more common in patients with CDK than in controls of similar age [5]. Occurrences of severe corneal ulcers complicated by bacterial infection, and their torpid evolution to perforation and endophthalmitis have also been reported in CDK [6,7]. …”

Section: Introductionmentioning

confidence: 99%

Genetic Background and Climatic Droplet Keratopathy Incidence in a Mapuche Population from Argentina

et al. 2013

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PurposeTo determine whether the incidence of and susceptibility to climatic droplet keratopathy (CDK), an acquired, often bilateral degenerative corneal disease, is influenced by the genetic background of the individuals who exhibit the disorder.MethodsTo determine whether the disease expression was influenced by the genetic ancestry of CDK cases in native Mapuche of the northwest area of Patagonia in Argentina, we examined mitochondrial DNA and Y-chromosome variation in 53 unrelated individuals. Twenty-nine of them were part of the CDK (patient) population, while 24 were part of the control group. The analysis revealed the maternal and paternal lineages that were present in the two study groups.ResultsThis analysis demonstrated that nearly all persons had a Native American mtDNA background, whereas 50% of the CDK group and 37% of the control group had Native American paternal ancestry, respectively. There was no significant difference in the frequencies of mtDNA haplogroups between the CDK patient and control groups. Although the Y-chromosome data revealed differences in specific haplogroup frequencies between these two groups, there was no statistically significant relationship between individual paternal genetic backgrounds and the incidence or stage of disease.ConclusionsThese results indicate a lack of correlation between genetic ancestry as represented by haploid genetic systems and the incidence of CDK in Mapuche populations. In addition, the mtDNA appears to play less of a role in CDK expression than for other complex diseases linked to bioenergetic processes. However, further analysis of the mtDNA genome sequence and other genes involved in corneal function may reveal the more precise role that mitochondria play in the expression of CDK.

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Infectious Keratitis in Climatic Droplet Keratopathy

Abstract: CDK is a predisposing factor for infectious keratitis. Treatment should be considered for advanced and nodular lesions, even if they are peripheral, to prevent infectious keratitis.

Cited by 6 publications

References 10 publications

Pearls and paradigms in Infective Keratitis

Pearls and paradigms in Infective Keratitis

Phototherapeutic keratectomy

Genetic Background and Climatic Droplet Keratopathy Incidence in a Mapuche Population from Argentina

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