Infectious Hepatitis and Down's Syndrome

Dallaire, Louis; Kingsmill-Flynn, D.

doi:10.1016/s0140-6736(67)90885-9

Cited by 7 publications

(2 citation statements)

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“…Trisomic carriers of HBsAg have been shown to suffer from chronic anicteric hepatitis [19]. Since acute and chronic infections with hepatitis virus are known to induce a number of immunological derangements, including the appearance of antibodies to human thyroglobulin (HTgAb) [6], the high frequency of the latter in DS might be tentatively attributed to chronic viral hepatitis rather than to primary immunodeficiency.…”

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Immunodeficiency in Down's syndrome: Relationship between presence of human thyroglobulin antibodies and HBsAg carrier status

et al. 1977

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The relationship between the presence of hepatitis B surface antigen (HBsAg) and antibodies to human thyroglobulin (HTgAb) has been studied in 110 subjects with Down's syndrome (DS) from 4 months to 50 years of age and in 122 controls carefully matched for sex, age and socio-environmental conditions. The overall percentage of HBsAg carriers was 22.7 in DS and 6.6 in controls and that of HTgAb-positive subjects was 41.8 in DS and 19.7 in controls. In DS the frequency of HTgAb-positive subjects was very high, even in the youngest age groups in which the percentage of HBsAg carriers was relatively low; the latter thereafter showed a marked increase with age. A positive association between the presence of HBsAg and HTgAb was found only in the oldest age group of DS subjects. It is thus concluded that in DS the high frequency of HTgAb cannot be attributed to chronic hepatitis B virus infection. On the contrary, the presence of HTgAb might well represent an early "marker" of immunodeficiency and increased susceptibility to infection with hepatitis B virus.

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Immunodeficiency in Down's syndrome: Relationship between presence of human thyroglobulin antibodies and HBsAg carrier status

et al. 1977

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“…It has been reported that subjects with viral hepatitis have an increased frequency of thyroid antibodies (Dallaire and Kingsmill-Flynn, 1967). Moreover, on the basis of a large epidemiological survey in Australia, Stoller and Gollniann (1965) postulated that maternal infection with the hepatitis virus was a cause of Down's syndrome.…”

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confidence: 99%