Infectious Etiologies of Rhabdomyolysis: Three Case Reports and Review

Singh, Upinder; Scheld, W. Michael

doi:10.1093/clinids/22.4.642

Cited by 203 publications

(211 citation statements)

References 106 publications

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“…9 Influenza types A and B, HIV, enteroviruses, Epstein-Barrvirus, cytomegalovirus, adenovirus, herpes simplex and varicella virus are the common viruses associated with rhabdomyolysis. 5 In our case respiratory syncytial virus was associated with rhabdomyolysis and prodromal period was seen between 6-10 days.…”

Section: Discussionmentioning

confidence: 48%

“…Recently, several cases of severe rhabdomyolysis associated with viral myositis were reported. 5 We did not find a child case with severe recurrent rhabdomyolysis associated with viral myositis in the literature. We aimed to present the clinical findings of the first pediatric case with severe recurrent rhabdomyolysis triggered by infections.…”

Section: Introductionmentioning

confidence: 78%

“…4 In case of rhabdomyolysis, acute necrosis of skeletal muscle fibers and the resulting blend into the extracellular environment of the cell content may cause severe acute renal failure. 5,6 However, many clinicians may fail to recognize rhabdomyolysis as an important complication associated with viral myositis. Recently, several cases of severe rhabdomyolysis associated with viral myositis were reported.…”

Section: Introductionmentioning

confidence: 99%

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Recurrent rhabdomyolysis in a child. Case presentation

et al. 2016

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Viral myositis associated with infections rarely may cause rhabdomyolysis. There is no any pediatric case with severe recurrent rhabdomyolysis triggered by infections in the literature. We reported a two-year-old boy who was hospitalized three times due to severe rhabdomyolysis associated with viral myositis in the winter months. This is the first child case presentation with severe rhabdomyolysis triggered by infections. Prednisolone and intravenous immunoglobulin treatments were ineffective in this case.

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Section: Discussionmentioning

confidence: 48%

Section: Introductionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

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Recurrent rhabdomyolysis in a child. Case presentation

et al. 2016

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“…Direct invasion of muscle cells and toxin generation have been proposed as two possible mechanisms of muscle injury because of either viral or bacterial agents. The risk of acute renal failure secondary to severe rhabdomyolysis after an infection ranges from 25% to 100% [29].…”

Section: Etiologiesmentioning

confidence: 99%

Crush injury and rhabdomyolysis

Malinoski

Slater

Mullins

2004

Critical Care Clinics

212

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Although clinical syndromes consistent with rhabdomyolysis were recognized in the late 19th and early 20th centuries, the modern history of the crush syndrome begins with Bywaters' and Beal's classic description of the entrapped bombing victims of London during World War II [1 -4]. They reported five cases of crush injury, in which victims had one or more of their extremities trapped under debris for prolonged periods of time. All five patients presented in shock, had swollen extremities, developed dark urine, progressed to renal failure, and eventually died. Histologic examination of the kidney revealed tubular necrosis and pigmented casts. In 1944, Bywaters and Stead identified myoglobin as the urinary pigment and proposed its role in the development of renal failure [5].Large numbers of patients with crush injuries and rhabdomyolysis have been reported after the collapse of mines [6,7], severe beatings [8], and earthquakes [9 -15]. In the United States, alcohol intoxication associated with prolonged muscle compression and seizures is the most common etiology of rhabdomyolysis [16]. Serum creatine kinase (CK) levels correlate with the degree of muscle injury [14] and can be used to assess the severity of rhabdomyolysis. Acute renal failure (ARF) is one of the most serious consequences of rhabdomyolysis and occurs in 4% to 33% of cases, carrying with it a mortality rate of 3% to 50% [17]. Rhabdomyolysis accounts for 5% to 7% of all cases of ARF in the United States [18].This article focuses on the pathophysiology and treatment of myoglobinuric renal failure caused by traumatic rhabdomyolysis and crush injuries.

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“…Legionella, Streptococcus and Salmonella species are the most common bacteria which may have a causative role in precipitating RM. Other infectious agents that have been associated with RM are: influenza virus, HIV, enterovirus and malaria [2][3][4]. In infection-associated RM, ARF and mortality reach 57% and 38% respectively [4].…”

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confidence: 99%