Infectious Eccrine Hidradenitis: A Report of 3 Cases and a Review of the Literature

Bassas-Vila, J.; Fernández‐Figueras, María Teresa; Romaní, Jorge; Ferrándiz, Carlos

doi:10.1016/j.ad.2013.04.016

Cited by 15 publications

(16 citation statements)

References 15 publications

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“…It has been suggested that Trichosporon has thinner hyphae and pseudohyphae as compared with Candida, and stains less prominently on GMS as compared with other fungi, but histopathological identification without the benefit of supplemental immunohistochemistry, enzyme‐linked immunosorbent assay (ELISA), and/or polymerase chain reaction (PCR) analysis is difficult . While the patients' skin findings conformed to classical descriptions of T. asahii infection, his biopsy with its dense, neutrophilic peri‐eccrine infiltrate more closely resembled NEH on preliminary inspection, an elusive entity observed most commonly in the context of chemotherapy for hematologic malignancy that is histologically characterized by the neutrophilic infiltration of eccrine gland acini with or without acinal necrosis . Infectious forms of NEH (better known as infectious eccrine hidradenitis, or IEH) have been described in the literature in the setting of HIV, Staphylococcus aureus, Streptococcus spp., Serratia marcescens, Nocardia spp., Mycobacterium chelonae , and Enterobacter cloacae but never in the context of Trichosporon .…”

Section: Discussionmentioning

confidence: 80%

Disseminated trichosporonosis with atypical histologic findings in a patient with acute lymphocytic leukemia

et al. 2018

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We report a case of disseminated Trichosporon asahii in a patient on systemic antifungal therapy who presented with multiple cutaneous nodules suggestive of fungal infection. Histologic features resembled neutrophilic eccrine hidradenitis but staining with periodic acid‐Schiff and Gomori methenamine silver confirmed the clinical diagnosis. This case highlights the importance of maintaining suspicion for trichosporonosis and contextualizing histologic findings within the underlying clinical picture.

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Section: Discussionmentioning

confidence: 80%

Disseminated trichosporonosis with atypical histologic findings in a patient with acute lymphocytic leukemia

et al. 2018

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“…Both cases suggest the possible effectiveness of treatment with systemic antibiotics, which supports the possible involvement of bacterial infection in the pathophysiology of this disease. It was reported that bacterial infection might be a triggering or causative factor in some cases of NEH and PEH . Noninfectious NEH is typically self‐limited, but infectious NEH requires antibiotic therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Noninfectious NEH is typically self‐limited, but infectious NEH requires antibiotic therapy. Therefore, in diagnosis of NEH, differentiation between infectious and noninfectious is important, but it is not possible to distinguish infectious from noninfectious NEH on the basis of clinical and histopathologic findings . Berk and colleagues proposed that, if NEH lesions last longer than 4 weeks, empiric antibiotics should be considered.…”

Section: Discussionmentioning

confidence: 99%

Neutrophilic superficial eccrine ductitis: Proposal of a new disease concept

Nagai

Nishigori

2018

Pediatric Dermatology

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A 3-year-old Japanese boy presented with a 3-month history of itchy erythematous papules on his trunk and forearms, the histologic findings of which were characterized by predominantly neutrophilic inflammation within and around the eccrine sweat ducts and obliteration and disruption of the superficial eccrine sweat ducts. Although the skin disorder had some clinical and histopathologic similarity to miliaria and neutrophilic eccrine hidradenitis, it was ultimately conformed to be neither disorder. Based on this and a case report in the Japanese literature of a 1-year-old boy with erythematous eruptions whose clinical and histopathologic findings were similar to those in our case, we propose the skin disorder in our case, referred to as "neutrophilic superficial eccrine ductitis," as a unique entity.

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“…In NEH, an aggregation of neutrophils occurs around the eccrine glands,1 which can be concentrated on the palms. NEH can be triggered by infections and can cause erythematous papules, nodules, plaques, pustules, purpura and urticaria 2. NEH can also be seen in some patients who underwent chemotherapy for malignancies 2…”

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confidence: 99%