Infectious diseases in the first year of life, perinatal characteristics and childhood acute leukaemia

Silva, N Jourdan-Da; Pérel, Yves; Méchinaud, Françoise; Plouvier, Emmanuel; Gandemer, Virginie; Lutz, Patrick; Vannier, Jean‐Pierre; Lamagnére, J L; Margueritte, Geneviève; Boutard, Patrick; Robert, Alain; Armari, C; Munzer, Martine; Millot, Frédéric; Lumley, L. De; Berthou, Christian; Rialland, Xavier; Pautard, Brigitte; Hémon, Denis; Clavel, Jacqueline

doi:10.1038/sj.bjc.6601384

Cited by 128 publications

(86 citation statements)

References 32 publications

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“…They concluded that the risk of developing acute leukemia was decreased in children who were exposed to common infections in the first year of life (OR = 0.76; 95% CI: 0.67 to 0.87). [24,25] These findings are consistent with the findings of Perillat et al, Jourdan-Da et al, Dockerty et al, and Ma X et al [15][16][17][18][19]21,22] In New Zealand, Dockerty et al conducted a case-control study that included 121 children diagnosed with acute leukemia and 303 controls (with ages less than 14 years in both groups). They found that exposure to the influenza virus is a risk factor for developing leukemia; that is, a child infected with the influenza virus during the first year of life has a 7-fold risk of developing acute leukemia compared with children who had influenza, with an OR of 6.8 (95% CI: 1.8-25.7).…”

Section: Epidemiological Studiessupporting

confidence: 79%

“…These indicators are designated as "proxies" and include socioeconomic status, surgical history, allergic diseases, immunizations, attendance at daycare, breastfeeding, neonatal infections, and prenatal history, among others. [14][15][16][17][18][19][20][21][22][23][24][25] …”

Section: Measuring Exposure To Infection With Proxy Variablesmentioning

confidence: 99%

“…Breastfeeding was not associated with the development of leukemia, but an increasing order of the child's birth increases the risk of developing acute lymphoblastic leukemia, with an OR of 2.0 (95% CI: 1.1-3.7). [15,16,32] Meanwhile, Rudant et al, also in France, used a case-control design of a National Register (ESCALE) and included 765 incident cases of acute leukemia and 1,681 controls. They observed positive associations when the child presented with recurrent common infections, a history of asthma or a history of eczema, with ORs of 0.7 (95% CI: 0.6-0.9), 0.7 (95% CI: 0.4-1.0) and 0.7 (95% CI: 0.6 -0.9), respectively.…”

Section: Epidemiological Studiesmentioning

confidence: 99%

“…For example, SteenselMoll et al measured socioeconomic status in The Netherlands (1973)(1974)(1975)(1976)(1977)(1978)(1979)(1980) according to the parents' education, while other authors have used, for example, the number of people per room, home ownership, and family income as indicators of socioeconomic status. [15][16][17]21,22,[31][32][33] …”

Section: Socioeconomic Statusmentioning

confidence: 99%

See 3 more Smart Citations

Infection During the First Year of Life and Acute Leukemia: Epidemiological Evidence

Flores-Lujano¹,

Núñez-Enríquez²,

López³

et al. 2013

Clinical Epidemiology of Acute Lymphoblastic Leukemia - From the Molecules to the Clinic

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Section: Epidemiological Studiessupporting

confidence: 79%

Section: Measuring Exposure To Infection With Proxy Variablesmentioning

confidence: 99%

Section: Epidemiological Studiesmentioning

confidence: 99%

Section: Socioeconomic Statusmentioning

confidence: 99%

See 2 more Smart Citations

Infection During the First Year of Life and Acute Leukemia: Epidemiological Evidence

Flores-Lujano¹,

Núñez-Enríquez²,

López³

et al. 2013

Clinical Epidemiology of Acute Lymphoblastic Leukemia - From the Molecules to the Clinic

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“…12,13,24,44,59 Childhood infection Table 2 shows twenty-three studies that evaluated the association between childhood infection and leukemia. Among those that analyzed infections in the first two years of life, five reported reduced risk of ALL associated with infection in the skin, 44 ears, 48,81 or gastrointestinal tract, 25 and episodes of roseola and/or fever and rash.…”

Section: Maternal Infectionmentioning

confidence: 99%

Infection and childhood leukemia: review of evidence

Maia¹,

Filho²

2013

Rev. Saude Publica

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OBJECTIVE:To analyze studies that evaluated the role of infections as well as indirect measures of exposure to infection in the risk of childhood leukemia, particularly acute lymphoblastic leukemia. METHODS:A search in Medline, Lilacs, and SciELO scientific publication databases initially using the descriptors "childhood leukemia" and "infection" and later searching for the words "childhood leukemia" and "maternal infection or disease" or "breastfeeding" or "daycare attendance" or "vaccination" resulted in 62 publications that met the following inclusion criteria: subject aged ≤ 15 years; specific analysis of cases diagnosed with acute lymphoblastic leukemia or total leukemia; exposure assessment of mothers' or infants' to infections (or proxy of infection), and risk of leukemia. RESULTS:Overall, 23 studies that assessed infections in children support the hypothesis that occurrence of infection during early childhood reduces the risk of leukemia, but there are disagreements within and between studies. The evaluation of exposure to infection by indirect measures showed evidence of reduced risk of leukemia associated mainly with daycare attendance. More than 50.0% of the 16 studies that assessed maternal exposure to infection observed increased risk of leukemia associated with episodes of influenza, pneumonia, chickenpox, herpes zoster, lower genital tract infection, skin disease, sexually transmitted diseases, Epstein-Barr virus, and Helicobacter pylori. CONCLUSIONS:Although no specific infectious agent has been identified, scientific evidence suggests that exposure to infections has some effect on childhood leukemia etiology. DESCRIPTORS:Children. Leukemia, etiology. Causality. Infection. Review. Leukemia makes up about one third of all malignancies in the 0-14 year old age group. The most common subtype, acute lymphoblastic leukemia (ALL), represents about 80.0% of these cases. 57 The incidence rate of ALL was estimated as 35.2 per million children aged under 15 in Brazil, and children under five are the most affected. 60Potential risk factors for childhood leukemia (CL) are conflicting. Exposure to ionizing radiation, commonly accepted as a cause of leukemia, does not explain all cases of leukemia in children.5 The etiology of CL has a multifactorial character. Leukemic cells that carry genetic alterations arise mainly before birth. Translocation between chromosomes 12 and 21 causes fusion of the TEL and AML1 gene; producing aberrant proteins that inhibit gene activity and change the capacity for self-renewal and differentiation of hematopoietic stem cells; this change represents the most common structural genetic abnormality in children with leukemia.45,74 About 1.0% of healthy newborns have this translocation and one RESUMO OBJETIVO: Analisar estudos que avaliaram o papel de infecções e de medidas indiretas de exposição às infecções no risco de leucemia infantil, principalmente da leucemia linfocítica aguda. MÉTODOS:A busca nas bases de dados Medline, Lilacs e SciELO utilizando-se inicialmente os de...

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Breastfeeding and Childhood Leukemia Incidence

2015

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IMPORTANCE Childhood cancer is a leading cause of mortality among children and adolescents in the developed world and the incidence increases by 0.9% each year. Leukemia accounts for about 30% of all childhood cancer but its etiology is still mostly unknown.OBJECTIVE To conduct a meta-analysis of available scientific evidence on the association between breastfeeding and childhood leukemia.DATA SOURCES A thorough search for articles published between January 1960 and December 2014 researching the association between breastfeeding and childhood leukemia was conducted on PubMed, the Cochrane Library, and Scopus (performed in July and December 2014), supplemented by manual searches of reference lists.STUDY SELECTION To be included in the meta-analyses, studies had to be case control; include breastfeeding as a measured exposure and leukemia as a measured outcome; include data on breastfeeding duration in months; and be published in a peer-reviewed journal with full text available in English. DATA EXTRACTION AND SYNTHESISThe search identified 24 relevant studies, 17 of which met all inclusion criteria. No publication bias or significant heterogeneity among these 17 studies were detected. The quality of each study that met the inclusion criteria was assessed using the Newcastle-Ottawa Scale. Multiple meta-analyses were conducted using the random effect model on raw data in the StatsDirect statistical program. MAIN OUTCOMES AND MEASURESNo or short duration of breastfeeding and the incidence of childhood leukemia. RESULTSThe meta-analysis of all 17 studies indicated that compared with no or shorter breastfeeding, any breastfeeding for 6 months or longer was associated with a 20% lower risk for childhood leukemia (odds ratio, 0.80; 95% CI, 0.72-0.90). A separate meta-analysis of 15 studies indicated that ever breastfed compared with never breastfed was associated with a 9% lower risk for childhood leukemia (odds ratio, 0.91; 95% CI, 0.80-1.04), although the definition of never breastfed differed between studies. All meta-analyses of subgroups of the 17 studies showed similar associations. Based on current meta-analyses results, 14% to 20% of all childhood leukemia cases may be prevented by breastfeeding for 6 months or more.CONCLUSIONS AND RELEVANCE Breastfeeding is a highly accessible, low-cost public health measure. This meta-analysis that included studies not featured in previous meta-analyses on the subject indicates that promoting breastfeeding for 6 months or more may help lower childhood leukemia incidence, in addition to its other health benefits for children and mothers.

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Infectious diseases in the first year of life, perinatal characteristics and childhood acute leukaemia

Cited by 128 publications

References 32 publications

Infection During the First Year of Life and Acute Leukemia: Epidemiological Evidence

Infection During the First Year of Life and Acute Leukemia: Epidemiological Evidence

Infection and childhood leukemia: review of evidence

Breastfeeding and Childhood Leukemia Incidence

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