Infectious Diseases in Pregnancy

Wigmore, Robin; Salgueiro, Francisco M.

doi:10.1007/978-3-319-39328-5_5

Cited by 1 publication

(1 citation statement)

References 49 publications

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“…Spiramycin (a macrolide antibiotic) is prescribed when primary maternal infection is diagnosed during gestation in an attempt to prevent MTCT [ 6 , 7 ]. Spiramycin is not approved in the United States (U.S.), but is accessible through a compassionate use program for toxoplasmosis during pregnancy [ 8 ]. The burden of congenital toxoplasmosis may be disproportionately borne by patients of lower socioeconomic strata, and those who lack access to antepartum screening and prevention.…”

Section: Introductionmentioning

confidence: 99%

A fresh look at the role of spiramycin in preventing a neglected disease: meta-analyses of observational studies

Montoya¹,

Laessig²,

Fazeli³

et al. 2021

Eur J Med Res

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Purpose We aimed to investigate the effect of antepartum treatment with spiramycin with or without subsequent pyrimethamine–sulfonamide–folinic acid, compared to no treatment, on the rate of mother-to-child transmission (MTCT) of Toxoplasma gondii (T. gondii) and incidence/severity of sequelae in the offspring. Methods Embase and PubMed were searched for literature on spiramycin in pregnant women suspected/diagnosed with T. gondii infection. Meta-analyses were performed using random-effects model. Results Thirty-three studies (32 cohorts and 1 cross-sectional study), with a total of 15,406 mothers and 15,250 offspring, were pooled for analyses. The MTCT rate for all treated patients was significantly lower than the untreated [19.5% (95% CI 14–25.5%) versus 50.7% (95% CI 31.2–70%), p < 0.001]. The transmission rate in patients on spiramycin monotherapy was also significantly lower than untreated [17.6% (95% CI 9.9–26.8%) versus 50.7% (95% CI 31.2–70%), p < 0.001]. Conclusion Results indicate significant reduction in MTCT rates following spiramycin treatment of suspected/diagnosed maternal T. gondii infection.

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Section: Introductionmentioning

confidence: 99%