Infectious Diseases

Kaschula, R. O. C.

doi:10.1007/978-1-4471-3025-3_14

Cited by 3 publications

(5 citation statements)

References 224 publications

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“…There may be lymphoid hyperplasia, arteriolar proliferation, and reticulum cell hyperplasia early in the course of infection. Granulomas with central areas of necrosis, multinucleated giant cells, and stellate multiple microabscesses may be found in later stages (3,11). However, histopathological findings are typical but not specific for CSD.…”

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confidence: 99%

“…However, histopathological findings are typical but not specific for CSD. Infections caused by other agents, such as lymphogranuloma inguinale caused by Chlamydia trachomatis, atypical mycobacteriosis, yersiniosis, tularemia, brucellosis, certain myco-ses, and chronic granulomatous disease of childhood must be considered in the differential diagnosis (11). Detection of B. henselae DNA in tissue samples therefore would be useful to confirm histologically suspected CSD.…”

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confidence: 99%

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Detection of Bartonella henselae DNA by Two Different PCR Assays and Determination of the Genotypes of Strains Involved in Histologically Defined Cat Scratch Disease

Sander

Posselt

Böhm³

et al. 1999

J Clin Microbiol

100

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Cat scratch disease (CSD) is a common cause of subacute regional lymphadenopathy, not only in children but also in adults. Serological and molecular studies demonstrated that Bartonella henselaeis the etiologic agent in most cases of CSD. Amplification of B. henselae DNA in affected tissue and detection of antibodies toB. henselae are the two mainstays in the laboratory diagnosis of CSD. We designed a retrospective study and investigated formalin-fixed, paraffin-embedded lymph nodes from 60 patients (25 female, 35 male) with histologically suspected CSD by PCR amplification. The sensitivities of two different PCR assays were compared. The first primer pair amplified a 296-bp fragment of the 16S rRNA gene in 36 of the 60 samples, corresponding to a sensitivity of 60%. The second primer pair amplified a 414-bp fragment of thehtrA gene in 26 of the 60 lymph nodes, corresponding to a sensitivity of 43.3%. Bartonella DNA could be detected in a total of 39 (65%) of the 60 lymph nodes investigated. However, histopathologic findings are typical but not specific for CSD and cannot be considered as a “gold standard” for diagnosis of CSD. The sensitivity of the PCR assays increased from 65 to 87% if two criteria (histology and serology) were used in combination for diagnosis of CSD. Two genotypes (I and II) of B. henselae are described as being involved in CSD. Genotype I was found in 23 (59%) and genotype II was found in 9 (23%) of the 39 PCR-positive lymph nodes. Seven (18%) lymph nodes were negative in both type-specific PCR assays. Thirty (50%) of our 60 patients were younger than 20 years old (15 were younger than 10 years), 20 (33%) were between 21 and 40 years old, and 10 (17%) patients were between 41 and 84 years old. Our data suggest that detection of Bartonella DNA in patients’ samples might confirm the histologically suspected diagnosis of CSD.

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confidence: 99%

mentioning

confidence: 99%

Detection of Bartonella henselae DNA by Two Different PCR Assays and Determination of the Genotypes of Strains Involved in Histologically Defined Cat Scratch Disease

Sander

Posselt

Böhm³

et al. 1999

J Clin Microbiol

100

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“…Only individuals with pneumonic plague are able to infect others through the respiratory route [2,[180][181][182][183]. Infection via this route leads to bacteria infecting the lungs, causing primary pneumonic plague in the individual infected [2,[179][180][181][182][183]. Individuals with pneumonic plague can also infect others via direct contact; those infected develop bubonic plague [2].…”

Section: Route-severity Relationshipmentioning

confidence: 99%

“…When human-to-human transmission of plague does occur, it is predominantly via the aerosol transmission route from those with pneumonic plague [2]. Those infected in this manner develop pneumonic plague [176,[179][180][181][182][183]. Due to pneumonic plague having an extremely high mortality rate (close to 100% if untreated [2]), current available evidence suggests there is low potential for severity to depend on infectious dose.…”

Section: Dose-severity Relationshipmentioning

confidence: 99%

“…Route-severity relationships are known to exist for Yersinia pestis. Only individuals with pneumonic plague are able to infect others through the respiratory route [2,[180][181][182][183]. Infection via this route leads to bacteria infecting the lungs, causing primary pneumonic plague in the individual infected [2,[179][180][181][182][183].…”

Section: Route-severity Relationshipmentioning

confidence: 99%

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Symptom propagation in respiratory pathogens of public health concern: a review of the evidence

Asplin,

Mancy,

Finnie

et al. 2024

J. R. Soc. Interface.

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Symptom propagation occurs when the symptom set an individual experiences is correlated with the symptom set of the individual who infected them. Symptom propagation may dramatically affect epidemiological outcomes, potentially causing clusters of severe disease. Conversely, it could result in chains of mild infection, generating widespread immunity with minimal cost to public health. Despite accumulating evidence that symptom propagation occurs for many respiratory pathogens, the underlying mechanisms are not well understood. Here, we conducted a scoping literature review for 14 respiratory pathogens to ascertain the extent of evidence for symptom propagation by two mechanisms: dose–severity relationships and route–severity relationships. We identify considerable heterogeneity between pathogens in the relative importance of the two mechanisms, highlighting the importance of pathogen-specific investigations. For almost all pathogens, including influenza and SARS-CoV-2, we found support for at least one of the two mechanisms. For some pathogens, including influenza, we found convincing evidence that both mechanisms contribute to symptom propagation. Furthermore, infectious disease models traditionally do not include symptom propagation. We summarize the present state of modelling advancements to address the methodological gap. We then investigate a simplified disease outbreak scenario, finding that under strong symptom propagation, isolating mildly infected individuals can have negative epidemiological implications.

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BartonellaandAfipia

Sander

2010

Topley &Amp; Wilson's Microbiology and Microbial Infections

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Infectious Diseases

Cited by 3 publications

References 224 publications

Detection of Bartonella henselae DNA by Two Different PCR Assays and Determination of the Genotypes of Strains Involved in Histologically Defined Cat Scratch Disease

Detection of Bartonella henselae DNA by Two Different PCR Assays and Determination of the Genotypes of Strains Involved in Histologically Defined Cat Scratch Disease

Symptom propagation in respiratory pathogens of public health concern: a review of the evidence

BartonellaandAfipia

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