Infectious Crystalline Keratopathy Caused by Candida parapsilosis

Rhem, Marcus N.; Wilhelmus, Kirk R.; Font, Ramon L.

doi:10.1097/00003226-199609000-00017

Cited by 25 publications

(11 citation statements)

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“…This newborn suffered from serious abnormalities of ectodermal and mesodermal tissues, characterized by atrophy of epidermis and dermis (6,11); since corneal tissue is of mesodermal origin and conjunctiva is derived from the ectodermic leaflet, it is likely that C. parapsilosis could gain access to the bloodstream directly through defective ocular barriers. The observation that ocular infections due to C. parapsilosis, though infrequent, have never been reported in association with systemic yeast dissemination (19,28) convincingly supports the notion that the integrity of ocular barriers efficaciously prevents the hematogenous dissemination of the yeast.…”

Section: Discussionmentioning

confidence: 55%

Horizontal Transmission of Candida parapsilosis Candidemia in a Neonatal Intensive Care Unit

Lupetti¹,

Tavanti²,

Davini³

et al. 2002

J Clin Microbiol

152

110

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This report describes the nosocomial acquisition of Candida parapsilosis candidemia by one of the six premature newborns housed in the same room of a neonatal intensive care unit at the Ospedale Santa Chiara, Pisa, Italy. The infant had progeria, a disorder characterized by retarded physical development and progressive senile degeneration. The infant, who was not found to harbor C. parapsilosis at the time of his admission to the intensive care unit, had exhibited symptomatic conjunctivitis before the onset of a severe bloodstream infection. In order to evaluate the source of infection and the route of transmission, two independent molecular typing methods were used to determine the genetic relatedness among the isolates recovered from the newborn, the inanimate hospital environment, hospital personnel, topically and intravenously administered medicaments, and indwelling catheters. Among the isolates collected, only those recovered from the hands of two nurses attending the newborns and from both the conjunctiva and the blood of the infected infant were genetically indistinguishable. Since C. parapsilosis was never recovered from indwelling catheters or from any of the drugs administered to the newborn, we concluded that (i) horizontal transmission of C. parapsilosis occurred through direct interaction between nurses and the newborn and (ii) the conjunctiva was the site through which C. parapsilosis entered the bloodstream. This finding highlights the possibility that a previous C. parapsilosis colonization and/or infection of other body sites may be a predisposing condition for subsequent C. parapsilosis hematogenous dissemination in severely ill newborns.

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Section: Discussionmentioning

confidence: 55%

Horizontal Transmission of Candida parapsilosis Candidemia in a Neonatal Intensive Care Unit

Lupetti¹,

Tavanti²,

Davini³

et al. 2002

J Clin Microbiol

152

110

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“…Severe keratitis may cause wet, necrotic stromal inflammation to develop with features indistinguishable from those of other forms of microbial keratitis 5. Infectious crystalline keratopathy has also been reported in some cases 517. Anterior chamber reactions are variable5 and may combine with endophthalmitis 1216…”

Section: Discussionmentioning

confidence: 99%

Candida parapsilosis keratitis treated successfully with topical and oral fluconazole

Chen

Liou

2016

Taiwan Journal of Ophthalmology

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A 73-year-old male patient presented with ocular pain, redness, and blurred vision in the left eye, which had been ongoing for more than 2 months. An oval-shaped paracentral corneal ulcer with stromal infiltration and a mild anterior chamber reaction were found. Despite treatment with empiric antibiotics, the lesion progressed and corneal thinning in the middle area was noted. The culture yielded Candida parapsilosis. We therefore prescribed topical 0.2% fluconazole (FCZ) in combination with oral FCZ as an antifungal treatment, following which the stromal infiltration gradually subsided. Complete epithelial-ization was noted on the 8th day after initiating FCZ therapy. There was no recurrent disease in the subsequent 2 years. Our case demonstrates that topical FCZ 0.2% in combination with oral FCZ can successfully treat C. parapsilosis keratitis and result in a good visual outcome.

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“…10 Since then, several reports of ophthalmic infections secondary to C. parapsilosis have appeared in the literature. [11][12][13][14][15][16][17] Furthermore, C. parapsilosis has emerged as an important nosocomial pathogen with many systemic clinical manifestations in addition to the ocular manifestation of endophthamlitis. 18 Overall, C. parapsilosis has accounted for 3% to 27% of cases of fungemia in large hospital-based studies.…”

Section: Discussionmentioning

confidence: 99%

Candida Parapsilosis Keratitis Following Treatment of Epithelial Ingrowth After Laser In Situ Keratomileusis

Solomon

Biser

Donnenfeld

et al. 2004

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Infectious Crystalline Keratopathy Caused by Candida parapsilosis

Cited by 25 publications

References 0 publications

Horizontal Transmission of Candida parapsilosis Candidemia in a Neonatal Intensive Care Unit

Horizontal Transmission of Candida parapsilosis Candidemia in a Neonatal Intensive Care Unit

Candida parapsilosis keratitis treated successfully with topical and oral fluconazole

Candida Parapsilosis Keratitis Following Treatment of Epithelial Ingrowth After Laser In Situ Keratomileusis

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