Infectious complications of prostate biopsy: winning battles but not war

Derin, Okan; Fonseca, Limirio; Sánchez-Salas, Rafael; Roberts, Matthew J.

doi:10.1007/s00345-020-03112-3

Cited by 36 publications

(31 citation statements)

References 88 publications

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“…A future study to evaluate the application of the coordinates in transperineal-based biopsies is required as transperineal prostate biopsies are increasingly adopted to minimize the risk of biopsy-related sepsis. 28 In our series, three of 93 patients experienced significant adverse symptoms that warranted hospital admission within 30 days of targeted prostate biopsies. Three patients (3.2%) developed urinary sepsis.…”

Section: Discussionmentioning

confidence: 82%

Developing a coordinate-based strategy to support cognitive targeted prostate biopsies and correlative spatial-histopathological outcome analysis

Clement

Day

Rooney

et al. 2021

Asian Journal of Andrology

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Lack of investment for magnetic resonance (MR) fusion systems is an obstacle to deliver targeted prostate biopsies within the prostate cancer diagnostic pathway. We developed a coordinate-based method to support cognitive targeted prostate biopsies and then performed an audit on cancer detection and the location of lesions. In each patient, the prostate is considered as two separate hemiprostates, and each hemiprostate is divided into 4 × 4 × 4 units. Each unit is therefore defined by a three-dimensional coordinate. We prospectively applied our coordinates approach to target 106 prostatic lesions in 93 men. Among 45 (of 106; 42.5%) lesions positive for cancer, 27 lesions (60.0%) harbored clinically significant disease. PSA density was significantly higher in patients with proven cancer (median: 0.264 ng ml −2 ) when compared to the noncancer group (median: 0.145 ng ml −2 ; P = 0.003, Wilcoxon rank-sum test). Lesions with Prostate Imaging-Reporting and Data System (PIRADS) score of 5 were found to have a cancer incidence of 65.2%, while PIRADS 4 and 3 lesions have a lower risk of cancer detection, as expected, at 37.3% and 31.3%, respectively. The probability of a lesion being cancerous in our series significantly decreases as we go from the “apex-to-base” dimension (odds ratio [OR]: 2.62, 95% confidence interval [CI]: 1.55–4.44, P = 0.00034). Our analysis also indicates that the probability of cancer decreases as the prostate volume increases (OR: 1.03, 95% CI: 1.01–1.05, P = 0.00327). Based on this feasibility study, the use of coordinates to guide cognitive targeted prostate biopsies warrants future validation study in additional centers.

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Section: Discussionmentioning

confidence: 82%

Developing a coordinate-based strategy to support cognitive targeted prostate biopsies and correlative spatial-histopathological outcome analysis

Clement

Day

Rooney

et al. 2021

Asian Journal of Andrology

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“…The prevalence of infectious complications after prostate biopsy is about 0.1 to 7%, and antibiotic prophylaxis is recommended 17 . Although cases of IE as an infective complication have been described, to our knowledge this is the first report of Aerococcus spp IE following a prostate biopsy.…”

Section: Discussionmentioning

confidence: 99%

Aerococcus spp infective endocarditis following a prostate biopsy: a case report

Santos-Veloso

Barros

Carvalho

et al. 2021

Rev. Inst. Med. trop. S. Paulo

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“…12 In a prospective study comparing trans-perineal and routine transrectal prostate biopsy, Hara et al found no difference in the rates of post-biopsy sepsis or fevers. 15,16…”

Section: Discussionmentioning

confidence: 99%

Infectious complications secondary to prostate biopsy

Mohammed¹,

Dieudonné²,

Ahsaini³

et al. 2021

UNOAJ

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Introduction: Prostate biopsy (PB) is a routine procedure performed by urologists in cases of suspected prostate cancer, any abnormality in the prostate-specific antigen (PSA) assay, and/or perceived by the digital rectal exam. Although this is a safe and rapid procedure, it is not without potentially serious complications, including infectious complications ranging from asymptomatic bacteriuria to acute prostatitis and even septic shock. Materials and methods: This work reports the experience of the urology department of the Hassan II University Hospital of Fez in the study of post-biopsy prostatitis through the analysis of a retrospective series of 538 cases during the period January 2014 - December 2018. Results: We report 11 cases of acute post-biopsy prostatitis diagnosed in the urology department of the Hassan II University Hospital in Fez. The bacteria most frequently involved in post-biopsy infections are gram-negative bacteria (Escherichia coli, Klebsiella pneumonia, Acinetobacter baumannii) although gram-positive cocci (Enterococcus faecalis and Staphylococcus saprophyticus) can also be responsible. Anaerobic bacteria are rarely found. The treatment of these post-biopsy infections is based on prolonged antibiotic therapy (3 to 6 weeks) using third-generation cephalosporins (Ceftriaxone). In our series, no death, septic shock, or prostatic abscess was found. The evolution was towards a good improvement under antibiotic treatment with discharge at home after 48 hours of apyrexia. Conclusion: The study of infectious complications secondary to prostate biopsy makes it possible to determine the most appropriate empirical (therapeutic and prophylactic) regimens to minimize the risks. Because of the prevalence of infection by multi-resistant bacteria, particularly to quinolones, the biopsy must be performed following the rules of antibiotic prophylaxis.

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Infectious complications of prostate biopsy: winning battles but not war

Cited by 36 publications

References 88 publications

Developing a coordinate-based strategy to support cognitive targeted prostate biopsies and correlative spatial-histopathological outcome analysis

Developing a coordinate-based strategy to support cognitive targeted prostate biopsies and correlative spatial-histopathological outcome analysis

Aerococcus spp infective endocarditis following a prostate biopsy: a case report

Infectious complications secondary to prostate biopsy

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