Infectious complications in neonatal transfusion: Narrative review and personal contribution

Bianchi, Maria Luisa; Orlando, Nicoletta; Valentini, Caterina Giovanna; Papacci, Patrizia; Vento, Giovanni; Teofili, Luciana

doi:10.1016/j.transci.2020.102951

Cited by 7 publications

(6 citation statements)

References 60 publications

(139 reference statements)

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“…The literature reports that the risk of CMV acquisition increases with blood transfusions. [8][9][10][11] Acquisition of infection is assumed to have not occurred during intrauterine life since serologies (IgG, IgM), CMV, Toxoplasma gondii, Rubella virus, and Herpes simplex virus were negative. Also, other manifestations of intrauterine infection such as SGA and IUGR picture were not present.…”

Section: Acquired Cytomegalovirus Retinitis 351mentioning

confidence: 99%

Acquired Cytomegalovirus Retinitis in Preterm Infant Hospitalized in the NICU

Tajalli,

Vafaee,

Safi

et al. 2024

Advances in Neonatal Care

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Background: Acquired human cytomegalovirus (CMV) is a noteworthy disease in infants. This case study will highlight the influence of early diagnosis of CMV retinitis (CMVR) on avoid visual impairment. Clinical Findings: We describe a preterm female infant with a birth weight of 2060 gr that was admitted for tracheostomy placement due to hypoxic-ischemic encephalopathy. There were no signs of CMV infection or sepsis in laboratory results upon admission such as serology (IgG, IgM antibodies), Toxoplasma gondii, Rubella virus, Herpes simplex virus, CMVR and urine polymerase chain reaction (PCR). Primary Diagnosis: Incidentally, upon screening for retinopathy of prematurity, diffuse occlusive vasculitis was detected in the retinal image on the 112th day of life. Intervention: Intravenous and intraocular ganciclovir were administered for 4 weeks. Outcomes: In the follow-up visit 6 weeks after discharge from the hospital, visual impairment was detected on both sides. Practice Recommendations: This is a report of a case of acquired CMVR, a silent finding, as an uncommon complication in preterm neonates during the hospital stay. This diagnosis should be taken into consideration in preterm infants, since early diagnosis and treatment are crucial to avoid visual impairment.

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Section: Acquired Cytomegalovirus Retinitis 351mentioning

confidence: 99%

Acquired Cytomegalovirus Retinitis in Preterm Infant Hospitalized in the NICU

Tajalli,

Vafaee,

Safi

et al. 2024

Advances in Neonatal Care

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“…Although simple and accurate methods have been developed to measure blood glucose and bilirubin, traditional lab-based blood analysis requires 200–500 μL of blood per test. For critically ill infants who require continuous monitoring, blood draws may remove up to 50% of total blood volume during the first weeks of life, putting newborns at risk of anemia and infections [ 10 , 11 , 12 , 13 ]. Our team recently developed an automated valve-enabled microfluidic device that allows us to isolate plasma and then detect biomarkers based on an input of 5 μL of whole blood [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

A Compact Control System to Enable Automated Operation of Microfluidic Bioanalytical Assays

et al. 2022

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We describe a control system for operating valve-enabled microfluidic devices and leverage this control system to carry out a complex workflow of plasma separation from 8 μL of whole blood followed by on-chip mixing of plasma with assay reagents for biomarker detection. The control system incorporates pumps, digital pressure sensors, a microcontroller, solenoid valves and off-the-shelf components to deliver high and low air pressure in the desired temporal sequence to meter fluid flow and actuate microvalves. Importantly, our control system is portable, which is suitable for operating the microvalve-enabled microfluidic devices in the point-of-care setting.

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“…Therefore, multiple small-volume transfusions are often required to deal with this issue. Subsequently, exposure to multiple donors in red blood cells (RBCs) transfusion practice causes concerns about the risk of transmitted infections (6) as well as the hazard of respiratory distress syndrome, bronchopulmonary dysplasia, retinopathy of prematurity, and necrotizing enterocolitis (7, 8). To reduce the exposure rate, developed countries have established some effective transfusion methods employing each blood donation for a particular newborn (7-16), such as using the programs with the technology of extending the RBCs stored up to 35-42 days by use of a sterile connection device.…”

Section: Introductionmentioning

confidence: 99%

A cost-analysis study of using adult red cell packs and Pedi-Packs in Newborn Intensive Care Units in Southern Iran

Haghpanah

Miladi

Zamani

et al. 2021

Preprint

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Background and objective: Saving blood products is an important public health issue especially in developing countries with limited financial resources. We aimed to suggest a new hypothetical model to make a change in the current blood transfusion policy in the newborn intensive care unit (NICU) to reduce wastage of blood supplies as well as the risk of exposure to multiple donors. Methods: In this cross-sectional study, all transfused neonates (n=70) who were admitted to NICU of Nemazee Hospital, a tertiary referral hospital in Southern Iran, were evaluated between March and June 2019. Based on the information of neonates’ transfusion during this study period and determined transfusion indices, a specific pediatric pack was suggested and the related total costs per transfusion, as well as the donor-exposure rate of the hypothetical and the current transfusion method, were compared. Results: Considering the mean number of transfusions per neonate: 4 and mean volume of transfused packed red cells: 20 ml per transfusion, the cost-analysis of pediatric and the adult pack was presented. Arithmetically, we proved a higher total cost per transfusion for using adult pack comparing to pediatric pack. Additionally, using a pediatric pack set leads to a 24% reduction in RBCs wastage per transfusion and a 68.13% reduction in donor-exposure rate.Conclusions: The assignment of a dedicated pediatric pack for neonates will be able to improve the cost-effectiveness by a substantial reduction in donor-exposure rate and blood wastage. This finding should be taken into consideration to generate economic growth and make improvements in child health status.

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Infectious complications in neonatal transfusion: Narrative review and personal contribution

Cited by 7 publications

References 60 publications

Acquired Cytomegalovirus Retinitis in Preterm Infant Hospitalized in the NICU

Acquired Cytomegalovirus Retinitis in Preterm Infant Hospitalized in the NICU

A Compact Control System to Enable Automated Operation of Microfluidic Bioanalytical Assays

A cost-analysis study of using adult red cell packs and Pedi-Packs in Newborn Intensive Care Units in Southern Iran

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