Septic lesions of various organs currently remain an important topic for doctors. Frequent occurrence is associated with the high prevalence of such diseases as hepatitis, HIV, intravenous drug abuse, diabetes mellitus, different immunosuppression conditions and increasing cases of medical manipulations and interventions (catheters, endoprostheses, pacemakers). Often the injury of the “target organs” from the primary source is a clinical debut of the disease, so early diagnosis and correct interpretation of the radiologic data help in planning of the treatment and reduce the number of lethal complications and chronic course of disease. This article is dedicated to the main CT-signs of septic pulmonary embolism, as well as its possible complications.