Infectious complications following allogeneic stem cell transplantation by using anti‐thymocyte globulin‐based myeloablative conditioning regimens in children with hemoglobinopathies

Goussetis, Evgenios; Efstathiou, Eleni; Paisiou, Anna; Avgerinou, Georgia; Zisaki, Kalliopi; Giamouris, Vangelis; Peristeri, Ioulia; Kitra, Vasiliki; Vessalas, George; Gamaletsou, Maria N.; Sipsas, Nikolaos V.; Graphakos, Stelios

doi:10.1111/tid.12358

Cited by 8 publications

(12 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These infectious complications are similar to those in patients transplanted without in vivo T cell depletion (32). However, rates of GVHD were lower after ATG-based conditioning (32).…”

Section: Disease-specific Outcomes Hemoglobinopathiessupporting

confidence: 63%

“…In order to prevent graft failure/rejection, in vivo T cell depletion is increasingly utilized in patients with hemoglobinopathies (32). An evaluation of IR in children with severe β thalassemia major following matched sibling donor (MSD) HCT found that the addition of ATG led to delayed CD8 T cell recovery at 6 months but no change in CD4 T cell reconstitution, which occurred at 12 months (33).…”

Section: Disease-specific Outcomes Hemoglobinopathiesmentioning

confidence: 99%

“…An evaluation of IR in children with severe β thalassemia major following matched sibling donor (MSD) HCT found that the addition of ATG led to delayed CD8 T cell recovery at 6 months but no change in CD4 T cell reconstitution, which occurred at 12 months (33). Use of ATG containing conditioning regimens was associated with variable rates of bacterial infection (17-70%) and cytomegalovirus (CMV) reactivation (36-45%) (32,33). These infectious complications are similar to those in patients transplanted without in vivo T cell depletion (32).…”

Section: Disease-specific Outcomes Hemoglobinopathiesmentioning

confidence: 99%

“…Use of ATG containing conditioning regimens was associated with variable rates of bacterial infection (17-70%) and cytomegalovirus (CMV) reactivation (36-45%) (32,33). These infectious complications are similar to those in patients transplanted without in vivo T cell depletion (32). However, rates of GVHD were lower after ATG-based conditioning (32).…”

Section: Disease-specific Outcomes Hemoglobinopathiesmentioning

confidence: 99%

See 3 more Smart Citations

Immune Reconstitution in Pediatric Patients Following Hematopoietic Cell Transplant for Non-malignant Disorders

Bhatt

Bednarski

2020

Front. Immunol.

View full text Add to dashboard Cite

Allogeneic hematopoietic cell transplant (HCT) is curative for pediatric patients with non-malignant hematopoietic disorders, including hemoglobinopathies, bone marrow failure syndromes, and primary immunodeficiencies. Early establishment of donorderived innate and adaptive immunity following HCT is associated with improved overall survival, lower risk of infections and decreased incidence of graft failure. Immune reconstitution (IR) is impacted by numerous clinical variables including primary disease, donor characteristics, conditioning regimen, and graft versus host disease (GVHD). Recent advancements in HCT have been directed at reducing toxicity of conditioning therapy, expanding donor availability through use of alternative donor sources, and addressing morbidity from GVHD with novel graft manipulation. These novel transplant approaches impact the kinetics of immune recovery, which influence post-transplant outcomes. Here we review immune reconstitution in pediatric patients undergoing HCT for non-malignant disorders. We explore the transplant-associated factors that influence immunologic recovery and the disease-specific associations between IR and transplant outcomes.

show abstract

“…These infectious complications are similar to those in patients transplanted without in vivo T cell depletion (32). However, rates of GVHD were lower after ATG-based conditioning (32).…”

Section: Disease-specific Outcomes Hemoglobinopathiessupporting

confidence: 63%

Section: Disease-specific Outcomes Hemoglobinopathiesmentioning

confidence: 99%

Section: Disease-specific Outcomes Hemoglobinopathiesmentioning

confidence: 99%

Section: Disease-specific Outcomes Hemoglobinopathiesmentioning

confidence: 99%

See 2 more Smart Citations

Immune Reconstitution in Pediatric Patients Following Hematopoietic Cell Transplant for Non-malignant Disorders

Bhatt

Bednarski

2020

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…Indeed, the use of myeloablative ATG-containing regimen is associated with a high risk of infections, including CMV, EBV, bacteremia, and invasive fungal infections. 10 In our material, we observed a relatively high incidence of bacterial infections and EBV viremia.…”

Section: Discussionmentioning

confidence: 55%

Immune recovery after in vivo T‐cell depletion myeloablative conditioning hematopoietic stem cell transplantation in severe beta‐thalassemia children

Qin

Shi

et al. 2019

European J of Haematology

View full text Add to dashboard Cite

Background The clinical outcome of hematopoietic stem cell transplantation (HSCT) in those with severe beta‐thalassemia (β‐TM) is closely related to post‐transplantation immune reconstitution (IR). However, the data on the IR in these settings are scarce. Methods A prospective analysis of the clinical outcome and IR in 47 children with severe β‐TM who underwent in vivo T‐cell depletion myeloablative conditioning and matched sibling donor HSCT was performed. Immune reconstitution, including immune cell subset counts, as well as the generation of new T and B cells assays after HSCT, was measured. Results In the first year after HSCT, bacterial infections and cytomegalovirus (CMV) reactivation were observed in 70.2% and 36.2% of the patients, respectively. In the same period, poor CD4+ T‐cell recovery was observed. The B cells recovered within 6 months. Natural killer (NK) cells recovered as early as 1 month, but their function was defective. Cord blood and bone marrow (CB + BM) group had slower T‐cell recovery, and higher B cells and NK cells in comparison with peripheral blood and bone marrow (PB + BM) group. Conclusions The high incidence of infection within 1 year after in vivo T‐cell depletion myeloablative conditioning HSCT in severe β‐TM was consistent with poor IR.

show abstract

Guidelines for the management of Toxoplasma gondii infection and disease in patients with haematological malignancies and after haematopoietic stem-cell transplantation: guidelines from the 9th European Conference on Infections in Leukaemia, 2022

Aerts,

Mehra,

Groll

et al. 2024

The Lancet Infectious Diseases

View full text Add to dashboard Cite

Infectious complications following allogeneic stem cell transplantation by using anti‐thymocyte globulin‐based myeloablative conditioning regimens in children with hemoglobinopathies

Abstract: The rate of infections after allo-SCT, using an ATG-containing preparative regimen, in our population of pediatric patients with hemoglobinopathies is comparable to that reported elsewhere with the use of non-ATG containing regimens.

Cited by 8 publications

References 27 publications

Immune Reconstitution in Pediatric Patients Following Hematopoietic Cell Transplant for Non-malignant Disorders

Immune Reconstitution in Pediatric Patients Following Hematopoietic Cell Transplant for Non-malignant Disorders

Immune recovery after in vivo T‐cell depletion myeloablative conditioning hematopoietic stem cell transplantation in severe beta‐thalassemia children

Guidelines for the management of Toxoplasma gondii infection and disease in patients with haematological malignancies and after haematopoietic stem-cell transplantation: guidelines from the 9th European Conference on Infections in Leukaemia, 2022

Contact Info

Product

Resources

About