volume 24, issue 4, P1019-1039 2010
DOI: 10.1016/j.idc.2010.07.009
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Nazia Hasan, Ari Pollack, Ilseung Cho

Abstract: Colorectal cancer is a major cause of cancer-related morbidity and mortality in the United States and many other regions of the world. Our understanding of the pathogenesis of colorectal cancer, from the precursor adenomatous polyp to adenocarcinoma, has evolved rapidly. Colorectal carcinogenesis is a sequential process characterized by the accumulation of multiple genetic and molecular alterations in colonic epithelial cells. However, the development of colorectal cancer involves more then just a genetic pred…

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