Infectious causes of cancer: Targets for intervention J.J. Goedert (Ed.)

DNA Tumor Viruses and Cell Metabolism

“…Because of their relatively small genomes and striking biological effects, it is generally assumed that DNA tumor viruses have evolved to target the minimal number of cellular nodes and pathways required for transformation. Studies of DNA viruses have led to the identification of viral genes responsible for cancer induction and paving the way to our current understanding of cancer at the molecular level [ 2 ]. In their life cycle, viruses replicate, inducing the cytopathic effect in the host cells and forming new viral particles.…”

“…As was discussed above, glucose is the preferential source of energy for cancer cells; therefore, they need massive supply of glucose compared to normal cells [ 45 ]. By hijacking glucose transport system, DNA tumor viruses are able to deliver huge amounts of glucose for proliferating cells, enhancing their tumorigenic capacity [ 2 ]. Several viral proteins can facilitate the glucose transport in cancer cells.…”

“…Viruses play an important role in cancerogenesis. Globally, it is estimated that approximately 20% of all cancers are linked to infectious agents [ 2 ]. The viral genes transcribed or expressed in infected cells modulate the physiological machinery of cells that leads to cell transformation and development of tumor.…”