Infectious bursal disease virus in poultry: current status and future prospects

Alkie, Tamiru Negash; Rautenschlein, Silke

doi:10.2147/vmrr.s68905

Cited by 34 publications

(17 citation statements)

References 136 publications

(144 reference statements)

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“…It has been shown that vaccines prepared from cvIBDV strains provide partial protection against vvIBDV strains, ultimately allowing infection of vaccinated chickens, which then excrete the virulent viruses. This is considered one of the reasons for the appearance of mutant vaccine strains causing outbreaks in vaccinated flocks [2]. The adaptation of escape mutant vaccine strains in regions using vaccines prepared from cvIBDV strains alongside indigenous field strains has been reported [1,11].…”

Section: Discussionmentioning

confidence: 99%

Sequence-based comparison of field and vaccine strains of infectious bursal disease virus in Ethiopia reveals an amino acid mismatch in the immunodominant VP2 protein

et al. 2020

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Sequencing of the VP2 region was carried out to identify amino acid mismatches between vaccine strains and field isolates of infectious bursal disease virus (IBDV). Viruses were isolated in chicken embryo fibroblast (DF-1) cells using pooled samples of bursa collected from nine outbreaks, which affected 30,250 chickens in five localities, with an overall mortality of 47.87%. Virus strains were identified by comparing the deduced amino acid sequence between positions 232 and 446 of the immunodominant VP2 epitope. All of the pooled samples were positive for IBDV. RT-PCR yielded a 645-bp DNA fragment of the VP2 gene. Phylogenetic analysis of this fragment revealed clustering of these isolates with very virulent IBDV strains. The amino acid sequences of these isolates were identical to those of the European very virulent strains UK 661 and DV 86, except at position 222, but differed from the vaccine strains used in Ethiopia, suggesting the possible introduction of virulent virus strains to Ethiopia from Europe. Our study demonstrates the widespread presence of very virulent strains of IBDV on poultry farms in Ethiopia and demonstrates the need to evaluate the protective level of existing vaccines against circulating field viruses.

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Section: Discussionmentioning

confidence: 99%

Sequence-based comparison of field and vaccine strains of infectious bursal disease virus in Ethiopia reveals an amino acid mismatch in the immunodominant VP2 protein

et al. 2020

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“…Infectious bursal disease (IBD), an immunosuppressive disease, caused by infectious bursal disease virus (IBDV) has always been a major concern for poultry farmers. IBDV can infect immature B-lymphocytes in the bursa of Fabricius (1) and result in vaccination failure and susceptibility of chickens to pathogens (2). Both maternal immunity and active immunity can protect chicks against IBDV infection.…”

Section: Introductionmentioning

confidence: 99%

Screening and Identification of a Chicken Dendritic Cell Binding Peptide by Using a Phage Display Library

Qiao

et al. 2019

Front. Immunol.

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Dendritic cells (DCs), as antigen-presenting cells, can initiate adaptive immune responses efficiently. Although the DC-targeting strategy has attracted more attention, relevant studies on chicken are rare. Here, specific chicken bone marrow DC-binding peptides were selected using a phage display peptide library and confirmed through ELISA, flow cytometry, fluorescence microscopy, and laser confocal microscopy. The peptide candidate SPHLHTSSPWER, named SP, was fused to the infectious bursal disease virus (IBDV) structural protein and protective antigen VP2. In vitro , the expression of DC markers (CD80, CD83, CD86, DEC205, and MHCII) and some cytokines (IFN-γ, IL-12, TNF-α, IL-1β, IL-6, and CXCLi1) by VP2-SP-stimulated DCs was significantly higher than that by DCs treated with the VP2-control peptide at 4 h ( p < 0.001). In addition, an oral vaccine targeting DCs was generated using chicken-borne Lactobacillus saerimneri M11 ( L. sae M11) to deliver VP2 fused with SP. Anti-IBDV mucosal and humoral immune responses were induced efficiently via oral administration, resulting in higher protective efficacy in the VP2-SP group than the VP2 group. Therefore, chicken DC targeting of IBDV protective antigen VP2 delivered by L. sae provides effective immune protection in chicken. Our study may promote research on the DC-targeting strategy to enhance the effectiveness of chicken vaccines.

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“…These strains are grouped into four characteristic pathotypes including classical, attenuated, antigenic variant, and very virulent strains [ 12 – 14 ]. Nearly 60–76% of IBDV isolates across four continents can be grouped as very virulent based on the global molecular epidemiological investigations [ 15 ]. Since the first report of the very virulent IBDV (vvIBDV) in the USA in 1957 [ 12 , 16 ], the disease has been spreading worldwide [ 15 ] including Egypt [ 17 – 19 ] and has undergone a complex evolution.…”

Section: Introductionmentioning

confidence: 99%

“…Nearly 60–76% of IBDV isolates across four continents can be grouped as very virulent based on the global molecular epidemiological investigations [ 15 ]. Since the first report of the very virulent IBDV (vvIBDV) in the USA in 1957 [ 12 , 16 ], the disease has been spreading worldwide [ 15 ] including Egypt [ 17 – 19 ] and has undergone a complex evolution. In Egypt, the vvIBDVs were first reported in 1989 [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Potential reverse spillover of infectious bursal disease virus at the interface of commercial poultry and wild birds

2020

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Recently, multiple spillover events between domesticated poultry and wild birds have been reported for several avian viruses. This phenomenon highlights the importance of the livestock-wildlife interface in the possible emergence of novel viruses. The aim of the current study was to investigate the potential spillover and epidemiological links of infectious bursal disease virus (IBDV) between wild birds and domestic poultry. To this end, twenty-eight cloacal swabs were collected from four species of free-living Egyptian wild birds (i.e. mallard duck, bean goose, white-fronted goose and black-billed magpie). Genetic and phylogenetic analysis of three positive isolates revealed that the IBDV/USC-1/2019 strain clustered with previously reported very virulent IBDV (vvIBDV) Egyptian isolates. Interestingly, two other wild bird-origin isolates (i.e. IBDV/USC-2/2019 and IBDV/USC-3/2019) grouped with a vaccine strain that is being used in commercial poultry. In conclusion, our results revealed the molecular detection of vaccine and vvIBDV-like strains in Egyptian wild birds and highlighted the potential role of wild birds in IBDV epidemiology in disease-endemic regions.

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Infectious bursal disease virus in poultry: current status and future prospects

Cited by 34 publications

References 136 publications

Sequence-based comparison of field and vaccine strains of infectious bursal disease virus in Ethiopia reveals an amino acid mismatch in the immunodominant VP2 protein

Sequence-based comparison of field and vaccine strains of infectious bursal disease virus in Ethiopia reveals an amino acid mismatch in the immunodominant VP2 protein

Screening and Identification of a Chicken Dendritic Cell Binding Peptide by Using a Phage Display Library

Potential reverse spillover of infectious bursal disease virus at the interface of commercial poultry and wild birds

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