Infectious Bursal Disease

Phylogenetic Characterization of Infectious Bursal Disease (IBD) Viruses Isolated From Field Outbreaks in Chickens From Behera And Alexandria Governorates, Egypt

“…The first reporting of the disease was in the area of Gumboro, Delaware, USA from broiler flocks in 1957 (Eterradossi and Saif, 2008).…”

“…The disease affect young chickens that had lymphoid tissues especially cloacal bursa (bursa of fabricious) in which it caused severe destructive lesions leading to immunodeppression and death (Eterradossi and Saif, 2013).…”

Growth of Different Infectious Bursal Disease Virus Strains in Cell Lines from Origin of Lymphoid Leukosis Tumors

“…IBDV has been successfully adapted to cell lines originated from chicken embryo, including chicken embryo bursal cells, kidney cells, and fibroblast cells [3,15,20,25,27]. IBDV also has been propagated on cell cultures including turkey and duck embryo cells [20], mammalian cell lines derived from rabbit kidneys [24], Vero cells [7,10,17], derived from African green monkey kidneys; BGM-70 cells [10], derived from givet monkey kidneys; and MA-104 cells [10] from fetal rhesus monkey kidneys.…”

Production of a phage-displayed single chain variable fragment antibody against infectious bursal disease virus

“…The virus is normally present within the bursa of Fabricius as well as other organs such as skeletal muscle, intestines, kidney, and spleen. Two serotypes of the virus have been isolated from chickens; serotype I is pathogenic with high antigenicity whereas serotype II is not pathogenic and is not followed by any clinical signs or immunosuppression [2].…”

“…This could be achieved based on clinical symptoms, flock history, and necropsy approaches. However, accurate detection can only be accomplished by applying diagnostic methods such as in situ hybridization, immunofluorescence, immunohistochemistry, RT-PCR, and enzyme-linked immunosorbent assay (ELISA) [2].…”