Infections with<i>Candidatus</i>Neoehrlichia mikurensis and Cytokine Responses in 2 Persons Bitten by Ticks, Sweden

Grankvist, Anna; Sandelin, Lisa Labbé; Andersson, Jennie; Fryland, Linda; Wilhelmsson, Peter; Lindgren, Per-Eric; Forsberg, Pia; Wennerås, Christine

doi:10.3201/eid2108.150060

Cited by 46 publications

(57 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Within the TBD STING material the following pathogens have been detected: Borrelia spp. [1], Tick-borne encephalitis virus [2], Anaplasma phagocytophilum [3], Rickettsia helvetica [4], Candidatus Neoehrlichia mikurensis [5]. Other assumed tick-borne pathogens that are yet to be detected within the TBD STING study include the bacteria Bartonella spp., Francisella tularensis and the parasite Toxoplasma gondii.…”

Section: Introductionmentioning

confidence: 99%

The Tick-Borne Diseases STING study: Real-time PCR analysis of three emerging tick-borne pathogens in ticks that have bitten humans in different regions of Sweden and the Aland islands, Finland

Cronhjort

Wilhelmsson²,

Karlsson

et al. 2019

Infection Ecology & Epidemiology

Self Cite

View full text Add to dashboard Cite

A milder climate has during the last decade contributed to an increased density and spreading of ixodid ticks, thus enhancing their role as emerging vectors for pathogenic microorganisms in northern Europe. It remains unclear if they contribute to the occurrence of infections caused by the bacteria Bartonella spp., Francisella tularensis subspecies holarctica and the parasite Toxoplasma gondii in Sweden and on the Åland islands, Finland. In this study, we want to improve understanding of the tick-borne transmission of these pathogens. Volunteers were recruited at primary healthcare centers. Ticks and blood samples were acquired from participants recruited in 2008 and 2009. Health questionnaires were completed, and medical records were acquired where applicable. Feeding time was estimated and screening of pathogens in the ticks was performed through real-time PCR. Ticks (n = 1849) were of mixed developmental stages: 76 larvae, 1295 nymphs, 426 adults and 52 undetermined. All analyzed ticks were considered negative for these pathogens since the CT-values were all below the detection limit for Bartonella spp. (1663 ticks), Francisella spp. (1849 ticks) and Toxoplasma gondii (1813 ticks). We assume that infections with these pathogens are caused by other transmission pathways within these regions of Sweden and the Åland islands, Finland.

show abstract

Section: Introductionmentioning

confidence: 99%

The Tick-Borne Diseases STING study: Real-time PCR analysis of three emerging tick-borne pathogens in ticks that have bitten humans in different regions of Sweden and the Aland islands, Finland

Cronhjort

Wilhelmsson²,

Karlsson

et al. 2019

Infection Ecology & Epidemiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…EM was reported in two cases where co-infection with A. phagocytophilum in one and B. burgdorferi s.l. in the other was present [46]. A Norwegian study, in which EM patients were screened by PCR for the presence of N. mikurensis, reported seven positive samples, of which only three were positive for B. burgdorferi s.l.…”

Section: Europeanmentioning

confidence: 99%

“…The most prevalent symptom in the 14 cases of neoehrlichiosis included [46,[118][119][120][121][122][123] fever (86%), less common were skin manifestations (erythematous rash and EM) and anemia (36% and 29%, respectively), and in fewer cases, symptoms such as malaise, chills, arthralgia, abdominal complaints, edema, myalgia, and weight loss were reported (ranging from 14% to 7%). General laboratory findings included elevated CRP values, leukocytopenia, thrombocytopenia, and elevated liver enzymes (Suppl.…”

Section: Clinical Presentationmentioning

confidence: 99%

“…This could confuse the identification of the causative agent of the disease. For example, erythema migrans (EM), a typical manifestation of Lyme borreliosis, has been reported in patients in which infection with N. mikurensis or B. miyamotoi was detected by molecular methods [45,46]. This does not mean that these microorganisms are able to cause EM; it is much more likely that the EM is caused by an infection with B. burgdorferi s.l.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of Disease Causality of Rare Ixodes ricinus-Borne Infections in Europe

et al. 2020

View full text Add to dashboard Cite

In Europe, Ixodes ricinus ticks transmit pathogens such as Borrelia burgdorferi sensu lato and tick-borne encephalitis virus (TBEV). In addition, there is evidence for transmission to humans from I. ricinus of Anaplasma phagocytophilum, Babesia divergens, Babesia microti, Babesia venatorum, Borrelia miyamotoi, Neoehrlichia mikurensis, Rickettsia helvetica and Rickettsia monacensis. However, whether infection with these potential tick-borne pathogens results in human disease has not been fully demonstrated for all of these tick-borne microorganisms. To evaluate the available evidence for a causative relation between infection and disease, the current study analyses European case reports published from 2008 to 2018, supplemented with information derived from epidemiological and experimental studies. The evidence for human disease causality in Europe found in this review appeared to be strongest for A. phagocytophilum and B. divergens. Nonetheless, some knowledge gaps still exist. Importantly, comprehensive evidence for pathogenicity is lacking for the remaining tick-borne microorganisms. Such evidence could be gathered best through prospective studies, for example, studies enrolling patients with a fever after a tick bite, the development of specific new serological tools, isolation of these microorganisms from ticks and patients and propagation in vitro, and through experimental studies.

show abstract

“…W Szwecji Grankvist i wsp. [68] poddali badaniu 102 osoby pokłute przez kleszcze na obecność we krwi DNA Candidatus N. mikurensis. Patogen wykryto u dwóch zdrowych kobiet (2%), u których wystąpiła wysypka rumieniowa.…”

Section: Neoerlichioza U Ludziunclassified

Candidatus Neoehrlichia mikurensis – distribution and evaluation of potential risk exposure for human health

Sawczyn-Domańska¹,

Wójcik-Fatla²

2019

Med Og Nauk Zdr.

View full text Add to dashboard Cite

Wprowadzenie i cel pracy. Choroby przenoszone przez kleszcze stanowią istotny problem z zakresu problematyki zdrowia publicznego. W ostatnich latach obserwuje się wzrost zachorowań na choroby odkleszczowe. Co więcej, rozwój metod badawczych w dziedzinie biologii molekularnej przyczynił się do odkrycia nieznanych chorobotwórczych mikroorganizmów występujących w kleszczach na terenie Europy, w tym Candidatus Neoehrlichia mikurensis. Celem pracy jest ocena potencjalnego narażenia ludzi na zakażenie wywołane bakteriami z gatunku Candidatus Neoehrlichia mikurensis w Polsce, na podstawie analizy dostępnego piśmiennictwa. Skrócony opis stanu wiedzy. Candidatus Neoehrlichia mikurensis są Gram-ujemnymi bakteriami wewnątrzkomórkowymi należącymi do rodziny Anaplasmataceae. Głównym wektorem bakterii są występujące powszechnie na terenie Europy kleszcze Ixodes ricinus. Za główny rezerwuar patogenu uważa się drobne gryzonie. W 2010 roku opublikowano pierwszy opis zachorowania na neoerlichiozę. W kolejnych latach opisano kilkanaście przypadków choroby, m.in. w Szwajcarii, Niemczech oraz Czechach, głównie u pacjentów z obniżoną odpornością. Podsumowanie. Obecnie biorąc pod uwagę dostępne dane epidemiologiczne, należy stwierdzić, iż neoerlichioza nie stanowi w Polsce dużego zagrożenia, aczkolwiek stwierdzona obecność patogenu w kleszczach Ixodes ricinus stwarza ryzyko wystąpienia choroby na terenie kraju. Dlatego konieczne wydaje się prowadzenie dalszych badań mających na celu szczegółowe poznanie częstości występowania patogenu w przyrodzie. Ponadto należy pamiętać, że neoerlichioza jest stosunkowo nową chorobą odkleszczową, o której wiedza nawet wśród służb medycznych jest niewielka, dlatego ważne są działania informacyjne dotyczące podniesienia świadomości na temat tej i innych chorób odkleszczowych.

show abstract

Infections withCandidatusNeoehrlichia mikurensis and Cytokine Responses in 2 Persons Bitten by Ticks, Sweden

Cited by 46 publications

References 15 publications

The Tick-Borne Diseases STING study: Real-time PCR analysis of three emerging tick-borne pathogens in ticks that have bitten humans in different regions of Sweden and the Aland islands, Finland

The Tick-Borne Diseases STING study: Real-time PCR analysis of three emerging tick-borne pathogens in ticks that have bitten humans in different regions of Sweden and the Aland islands, Finland

Evaluation of Disease Causality of Rare Ixodes ricinus-Borne Infections in Europe

Candidatus Neoehrlichia mikurensis – distribution and evaluation of potential risk exposure for human health

Contact Info

Product

Resources

About