Infections Requiring Hospitalization in Patients on Hemodialysis

Gilbertson, David T.; Wetmore, James B.

doi:10.2215/cjn.10891015

Cited by 1 publication

(2 citation statements)

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“…Infection is the second leading cause of hospitalization and death in MHD patients [19]. Hospitalization rates for pneumonia have not improved [4]. Therefore, how to strengthen the strategies of prevention and control the infection in hemodialysis patients are important issues clinicians faced.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that the prevalence rate of pneumonia is higher in MHD patients than in the general population, and the mortality rates from the pulmonary infection in dialysis patients are 14-16-fold higher than in the general population [2,3]. A marked lack of progress in hospitalization rates due to pneumonia still exists [4,5]. And this trend is getting serious [1].…”

Section: Introductionmentioning

confidence: 99%

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The Predictive Value of NT-Pro-Brain Natriuretic Peptide for Risk of Pneumonia in Patients on Maintenance Hemodialysis

et al. 2020

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Background/Aims: Pneumonia is a common type of infection in maintenance hemodialysis (MHD) patients, while the treatment and prevention progress still keep limited. N-terminal-pro-brain natriuretic peptide (NT-proBNP) is an important marker in reflecting cardiac failure which also is a risk factor for pneumonia. This study aimed to determine the possible predictive value of NT-proBNP for pneumonia in MHD patients. Methods: In this prospective study, the basic information of 276 MHD patients was collected in Fudan university Zhongshan hospital, followed up for 1 year. The primary endpoint was the first pneumonia event during followup. The value of NT-proBNP in patients with pneumonia and without pneumonia was analyzed, to elucidate the predictive value of the NT-proBNP in hemodialysis patients with pneumonia. Results: Two hundred and seventy-six patients were finally enrolled in this prospective study, including 170 men. The mean age was 59.7 ± 14.0 years old. The average duration of hemodialysis is 56 (30-82.8) months. Enrolled patients were followed up for 1 year. During follow-up, 38 patients got pneumonia. After adjustment for other con-founding factors, age (hazard ratio [HR] 1.031, 95% CI 1.003-1.060, p = 0.028), log NT-proBNP (HR 2.512, 95% CI 1.124-5.612, p = 0.025), history of smoking (HR 6.326, 95% CI 2.505-15.974, p < 0.001), β2-microglobin (HR 1.042, 95% CI 1.007-1.079, p = 0.019), and history of cerebrovascular disease (HR 2.303, 95% CI 1.107-4.719, p = 0.026) were independent predictors of pneumonia. Receiver operating characteristic curves of log NT-proBNP to predict 1 year pneumonia cases, log NT-proBNP had an area under the curve of 0.647 (95% CI [0.564-0.729], p < 0.01). Conclusions: NT-proBNP is a predictive factor of pneumonia in hemodialysis patients.

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Section: Discussionmentioning

confidence: 99%