Infections in patients using ventricular-assist devices: Comparison of the diagnostic performance of 18F-FDG PET/CT scan and leucocyte-labeled scintigraphy

Vaugelade, C. De; Mesguich, Charles; Nubret, Karine; Camou, Fabrice; Greib, C.; Dournes, Gaël; Debordeaux, F.; Hindié, Elif; Barandon, Laurent; Tlili, Ghoufrane

doi:10.1007/s12350-018-1323-7

Cited by 51 publications

(38 citation statements)

References 45 publications

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“…The most common imaging modalities to date are cardiac ultrasonography or CT imaging to evaluate for device-related infection, however nuclear imaging using positron emission tomography (PET)/CT has now come to the forefront of diagnostic testing. A recently published retrospective study in the Journal of Nuclear Cardiology revealed that PET/CT scanning showed significantly higher sensitivity when compared with radio-labelled leucocyte scan 8. When compared with CT imaging, another prospective study showed that PET/CT imaging was a useful technique for identifying LVAD infection and determining the site and pattern of infection which had significant downstream effects for mortality and patient outcomes 9…”

Section: Discussionmentioning

confidence: 99%

DisseminatedCryptococcus neoformansinfection in a left ventricular assist device recipient

Jandhyala¹,

Tan

Stahr

et al. 2019

BMJ Case Rep

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A 51-year-old man with a medical history of coronary artery disease and dyslipidaemia presented with acute myocardial infarction resulting in cardiogenic shock, necessitating intra-aortic balloon pump placement and extracorporeal membrane oxygenation (ECMO). His hospital course was complicated by several infectious complications including ECMO circuit Pseudomonas aeruginosa bloodstream infection and presumed infected right atrial thrombus. He subsequently underwent urgent left ventricular assist device placement and had a prolonged hospital stay. On day 100 of admission, he developed acute hypoxic respiratory distress with new pulmonary infiltrates. Sputum cultures grew Cryptococcus neoformans. Blood culture also grew C. neoformans after 96 hours of incubation and cryptococcal serum antigen was elevated at 1:20. Cerebrospinal fluid studies from a lumbar puncture were normal. He was treated with 2 weeks of combination antifungal therapy followed by life-long fluconazole suppression.

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Section: Discussionmentioning

confidence: 99%

DisseminatedCryptococcus neoformansinfection in a left ventricular assist device recipient

Jandhyala¹,

Tan

Stahr

et al. 2019

BMJ Case Rep

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“…In doubtful cases, white blood cell single-positron emission tomography (WBC-SPECT) can further help define the presence/absence of infection at PVE (11,13,69). In doubtful cases, WBC-SPECT can help define the presence/absence of infection of the pump and cannula (72).…”

Section: Image Analysis and Interpretationmentioning

confidence: 99%

Procedural recommendations of cardiac PET/CT imaging: standardization in inflammatory-, infective-, infiltrative-, and innervation (4Is)-related cardiovascular diseases: a joint collaboration of the EACVI and the EANM

Slart

Glaudemans

Gheysens

et al. 2020

Eur J Nucl Med Mol Imaging

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With this document, we provide a standard for PET/(diagnostic) CT imaging procedures in cardiovascular diseases that are inflammatory, infective, infiltrative, or associated with dysfunctional innervation (4Is). This standard should be applied in clinical practice and integrated in clinical (multicenter) trials for optimal procedural standardization. A major focus is put on procedures using [18F]FDG, but 4Is PET radiopharmaceuticals beyond [18F]FDG are also described in this document. Whilst these novel tracers are currently mainly applied in early clinical trials, some multicenter trials are underway and we foresee in the near future their use in clinical care and inclusion in the clinical guidelines. Finally, PET/MR applications in 4Is cardiovascular diseases are also briefly described. Diagnosis and management of 4Is-related cardiovascular diseases are generally complex and often require a multidisciplinary approach by a team of experts. The new standards described herein should be applied when using PET/CT and PET/MR, within a multimodality imaging framework both in clinical practice and in clinical trials for 4Is cardiovascular indications.

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“…de Vaugelade et al [33] compared the diagnostic performance of FDG PET/CT and leucocyte labeled scintigraphy and demonstrated that FDG PET/CT showed greater sensitivity (95.2% vs. 71.4%, respectively). A recent analysis of 57 patients who underwent 85 PET/CT scans showed that a threshold of peak standardized uptake value (SUVpeak) of 2.5 could accurately diagnose driveline infections.…”

Section: Left Ventricular Assist Device Infectionmentioning

confidence: 99%

F-18 fluorodeoxyglucose positron emission tomography/computed tomography in the infection of heart

Kong

2021

Yeungnam Univ J Med

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Infections involving the heart are becoming increasingly common, and a timely diagnosis of utmost importance, despite its challenges. F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is a recently introduced diagnostic tool in cardiology. This review focuses on the current evidence for the use of FDG PET/CT in the diagnosis of infective endocarditis, cardiac implantable device infection, left ventricular assist device infection, and secondary complications. The author discuss considerations when using FDG PET/CT in routine clinical practice, patient preparation for reducing physiologic myocardial uptake, acquisition of images, and interpretation of PET/CT findings. This review also functions to highlight the need for a standardized acquisition protocol.

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Infections in patients using ventricular-assist devices: Comparison of the diagnostic performance of 18F-FDG PET/CT scan and leucocyte-labeled scintigraphy

Abstract: F-FDG PET/CT and radiolabeled leucocyte scintigraphy single-photon emission computed tomography carry high performance in the diagnostic of LVAD infections. F-FDG PET/CT shows significantly higher sensitivity and could be proposed as first-line nuclear medicine procedure.

Cited by 51 publications

References 45 publications

DisseminatedCryptococcus neoformansinfection in a left ventricular assist device recipient

DisseminatedCryptococcus neoformansinfection in a left ventricular assist device recipient

Procedural recommendations of cardiac PET/CT imaging: standardization in inflammatory-, infective-, infiltrative-, and innervation (4Is)-related cardiovascular diseases: a joint collaboration of the EACVI and the EANM

F-18 fluorodeoxyglucose positron emission tomography/computed tomography in the infection of heart

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