Infections in Pancreatic Inflammatory Disease: Clinical Trials for Antibiotic Prophylaxis

Bassi, Claudio

doi:10.1159/000055812

Cited by 9 publications

(2 citation statements)

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“…Finally, the antibiotics used in the studies varied ( table 3 ); one study with imipenem [14] , one study with meropenem [19] , two with cephalosporins [13,15] , and two with a combination of third-generation fluoroquinolones and metronidazole [7,16] . This makes it difficult to compare the outcome, since it could be influenced by, amongst others, the level of penetration of the antibiotics in (necrotic) pancreatic tissue and the antimicrobial spectrum of the antibiotics [27][28][29][30] .…”

Section: Discussionmentioning

confidence: 99%

Randomized Controlled Trials of Antibiotic Prophylaxis in Severe Acute Pancreatitis: Relationship between Methodological Quality and Outcome

Vries

Besselink

Buskens³

et al. 2007

Pancreatology

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Aim: To evaluate the methodological quality of randomized controlled trials (RCTs) of systemic antibiotic prophylaxis in severe acute pancreatitis in relation to outcome. Methods: The MEDLINE, EMBASE and Cochrane databases were searched for RCTs that studied the effectiveness of systemic antibiotic prophylaxis in severe acute pancreatitis. A meta-analysis was performed with a random effects model. Methodological quality was quantified by a previously published scoring system (range 0–17 points). Results: Six studies, with a total of 397 participants, obtained a methodological score of at least 5 points and were included. Systemic antibiotic prophylaxis had no significant effect on infection of pancreatic necrosis (absolute risk reduction (ARR) 0.055; 95% CI –0.084 to 0.194) and mortality (ARR 0.058, 95% CI –0.017 to 0.134). Spearman correlation showed an inverse association between methodological quality and ARR for mortality (correlation coefficient –0.841, p = 0.036). Conclusions: The inverse relationship between methodological quality and impact of antibiotic prophylaxis on mortality emphasizes the importance of high-quality RCTs. At present, adequate evidence for the routine use of antibiotic prophylaxis in severe acute pancreatitis is lacking.

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Section: Discussionmentioning

confidence: 99%

Randomized Controlled Trials of Antibiotic Prophylaxis in Severe Acute Pancreatitis: Relationship between Methodological Quality and Outcome

Vries

Besselink

Buskens³

et al. 2007

Pancreatology

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show abstract

“…22,26,27,28,31,32 São muitos os fatores responsáveis pelo prognóstico desfavorável na PA grave, dentre eles se destacam a ocorrência de complicações decorrentes da síndrome da resposta inflamatória sistêmica (SRIS) e a ocorrência de infecção pancreática. 5,6,8,23,27,28,31,33,34,35 Duas fases são determinantes na evolução e no prognóstico da PA Este fato suporta a teoria de participação dos macrófagos na translocação bacteriana em inflamações sistêmicas graves.…”

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Translocação bacteriana na pancreatite aguda: efeito da administração de indometacina

Matheus¹

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Complications of Pancreatitis

Howell¹

2005

Advanced Digestive Endoscopy: ERCP

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Infections in Pancreatic Inflammatory Disease: Clinical Trials for Antibiotic Prophylaxis

Cited by 9 publications

References 12 publications

Randomized Controlled Trials of Antibiotic Prophylaxis in Severe Acute Pancreatitis: Relationship between Methodological Quality and Outcome

Randomized Controlled Trials of Antibiotic Prophylaxis in Severe Acute Pancreatitis: Relationship between Methodological Quality and Outcome

Translocação bacteriana na pancreatite aguda: efeito da administração de indometacina

Complications of Pancreatitis

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