Infections in children with diabetes

Calliari, Luís Eduardo; Almeida, Flávia Jaqueline; Noronha, Renata Maria de

doi:10.1016/j.jped.2019.09.004

Cited by 18 publications

(18 citation statements)

References 38 publications

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“…Children with poorly controlled diabetes have increase susceptibility to bacterial and fungal infection due to various alterations in their immune response such as decreased T-lymphocyte and neutrophil function, decreased inflammatory cytokine secretion, decreased complement system and anti-oxidant system responses, and probably decreased antibody response (6,7). There is no substantial reason to believe that the clinical course of children with poorly controlled diabetes and COVID-19 could be different from what has been observed in adult patients.…”

Section: Poor Metabolic Controlmentioning

confidence: 99%

“…The risk of getting infected by SARS-CoV-2 also increases in patients with poor control of diabetes(6). Consequently, the risk of diabetes related complications such as diabetic ketoacidosis (DKA) as well as progression to severe COVID-19 increases in these patients.Recent reports of adult diabetes patients with COVID-19 suggest an increased risk of severity due to several factors such as release of tissue injury-related enzymes, excessive uncontrolled inflammation responses, hypercoagulability and dysregulation of glucose metabolism(8).…”

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confidence: 99%

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<strong>COVID-19: Considerations for Children and Adolescents with Diabetes</strong>

Dayal¹

2020

Preprint

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Recent reports suggest that the clinical course of coronavirus disease 2019 (COVID-19) in previously healthy children is usually milder as compared to adults. However, children with co-morbid conditions such as diabetes are at increased risk of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as well as morbidity and mortality due to COVID-19. Experience in adults with diabetes shows that they are prone to faster metabolic decompensation, develop diabetes-related complications and have a poor prognosis when hospitalised with COVID-19. The data in children is limited. The aim of this mini-review is to discuss the possible risks to children and adolescents with diabetes during the current pandemic and the special considerations in management in those affected with COVID-19.

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Section: Poor Metabolic Controlmentioning

confidence: 99%

mentioning

confidence: 99%

<strong>COVID-19: Considerations for Children and Adolescents with Diabetes</strong>

Dayal¹

2020

Preprint

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“…[2] They may occur preferentially in diabetic patients due to their immune system disorders. [3] The association between diabetes mellitus and oral infections is very common. It is bidirectional and it is considered as a debatable issue in the medical literature.…”

Section: Introductionmentioning

confidence: 99%

“…It is bidirectional and it is considered as a debatable issue in the medical literature. [3] It is therefore very important to establish awareness of the potential consequences of oral infections in dia-betic patients to avoid diabetic ketoacidosis. [2] Oral infections are various; they could include apical periodontitis, periodontitis, and cysts [4] In fact, the development of apical periodontitis in endodontic practice results from root canal space infection.…”

Section: Introductionmentioning

confidence: 99%

Odontogenic Infection Leading to Multiple Decompensations of Diabetic Ketoacidosis

Kallel¹

2021

J Pediatr Dent

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The aim of this case report was to highlight the association between Diabetic Ketoacidosis (DKA) and apical periodontitis through a case report involving a child suffering from DKA. The association between oral infections and diabetes has always been a debatable issue in the medical literature. Diabetic ketoacidosis (DKA) is a serious complication of uncontrolled diabetes. Oral infections, such as apical periodontitis is reported to be as a possible cause. Periapical lesions should initially be managed by a conservative non-surgical treatment. However, in cases of failure, endodontic surgery should be adopted. An 11-year-old child with type 1 diabetes under insulin therapy was hospitalized for DKA in 2019. A dentoalveolar abscess related to the upper right central incisor (11) was suspected as a possible cause of DKA. He had a history of trauma 3 years earlier followed by a coronal fracture of the 11. He also had an episode of DKA in 2018 and the same infection focus was identified as a possible factor but the patient did not finish his treatment. The radiograph showed a periapical lesion with radiolucency related to the open apex of the 11. Endodontic treatment was performed and the root canal system was obturated. The 3-month follow-up radiograph showed a favorable healing of the periapical lesion and the child had a stabilization of his diabetes.Unfortunately, 2 months later, he was hospitalized for another episode of DKA. After exploration, the same dentoalveolar abscess related to the 11 was reported as a possible factor. The radiograph showed persistence of the periapical lesion. An endodontic surgery was therefore indicated. Twelve months later, complete healing of the periapical lesion was noted. The patient has not undergone an episode of DKA ever since.

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“…cetoacidose diabética. O tratamento inclui a utilização de insulina exógena, controle da glicemia, alteração de hábitos alimentares, exercícios físicos, suporte psicológico para a criança, familiares e amigos, assim como o desenvolvimento da prática do autocuidado(CALLIARI, 2017;MONTENEGRO JUNIOR;VENCIO, 2017).As mudanças vivenciadas na dinâmica familiar muitas vezes são repentinas e impactantes, principalmente no que refere às alterações nos hábitos alimentares, como o controle da ingestão de carboidratos. Além disso, há necessidade de enfrentamento no tocante à idealização da criança saudável, fato percebido inicialmente com o desarranjo dos processos e papéis familiares e, posteriormente, sua busca por adaptação.…”

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