Infections Following Kidney Transplant in Children: A Single-Center Study

Fernandes, Alexandre Ribeiro; Rocha, Liliana; Costa, Teresa; Matos, Paula; Faria, Maria do Sameiro; Marquès, Laura; Mota, Conceição; Henriques, António Castro

doi:10.4236/ojneph.2014.43017

Cited by 6 publications

(8 citation statements)

References 17 publications

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“…Among Gram positive organism isolated, Enterococcus spp and MRSA highest sensitivity was seen to linezolid and vancomycin (Table 2). Despite improved surgical techniques, antimicrobial prophylaxis, new immunesuppressive therapies and hygiene measures in the management of transplant patients, infectious complications remain a major cause of morbidity and mortality in solid organ transplantation (SOT) patients, and urinary tract infection (UTI) is one of the most common infectious complication among them [1][2][3][4][5]. The high prevalence of UTI after kidney transplantation could be because of the immunosuppressive drugs.…”

Section: Resultsmentioning

confidence: 99%

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Organisms Isolated and Their Antibiotic Sensitivity Pattern from Renal Transplant Recepients in Kidney Transplant Unit

Nazir¹,

Angmo²,

Fomda

et al. 2018

JAMMR

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Aim: Despite improvements on immunosuppressive therapy and surgical techniques, infections remain important complication in renal transplant and have been associated with increased morbidity and graft rejection. Role of microbiological cultures in isolating bacteria and formulating their antibiogram has potential benefits with regards to targeted therapy for MDR bacteria. No such study has been conducted previously from this region so we designed this study to find out the organisms causing infections in renal transplant patients and their antibiotic susceptibility pattern. Materials and Methods: This retrospective study was conducted over a period of 1 year from 2016 to 2017. All samples were sent from Kidney Transplant Unit (KTU) for culture and sensitivity irrespective of duration of post renal transplant. Qualitative culture of other infected body fluids was performed on blood agar, MacConkey agar plate (Hi media, India). Positive cultures were processed for antimicrobial susceptibility testing on Mueller-Hinton agar plates, using the Kirby-

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Section: Resultsmentioning

confidence: 99%

“…Renal transplantation is the ideal method for treating patients with end-stage renal disease. Despite improvements on immunosuppressive therapy and surgical techniques, infections remain important complication and have been associated with increased morbidity and graft rejection [1,2].…”

Section: Introductionmentioning

confidence: 99%

Organisms Isolated and Their Antibiotic Sensitivity Pattern from Renal Transplant Recepients in Kidney Transplant Unit

Nazir¹,

Angmo²,

Fomda

et al. 2018

JAMMR

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“…Four months after KT the patient presented the same clinical aspect, elevated BUN and creatinine, accompanied by aregenerative anemia, leukopenia (WBC=3000/mm 3 ) and thrombocytopenia (40000/mm 3 ). A second acute rejection crisis was suspected.…”

Section: To the Editormentioning

confidence: 92%

“…[2] Through the use of aggressive treatment protocols for acute rejection, the susceptibility to infection and secondary neoplastic disease were greatly increased, as shown in our 2 case presentations. Infection remains the leading cause of hospitalization, following a KT [3].…”

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confidence: 99%

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Severe infections in kidney transplanted children

Bizo¹,

Bulata²

2015

Romanian Review of Laboratory Medicine

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Infectious disease risks in pediatric renal transplantation

Huang

Danziger‐Isakov

2018

Pediatr Nephrol

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Renal transplantation is a vital treatment option in children with ESRD with more than 10,000 pediatric kidney transplants and survival rates of greater than 80% at 10 years post-transplant in the USA alone. Despite these advances, infection remains a significant cause of morbidity in pediatric recipients. Screening potential organ donors and recipients is imperative to identify and mitigate infectious risks in the transplant patient. Despite the unique risks of each patient, the timing of many infections post-transplant is predictable. In early post-transplant infections (within 30 days), bacterial and fungal pathogens predominate with donor-derived events and nosocomial infections. In the intermediate period (31-180 days after transplant), latent infections from donor organs, such as EBV and CMV, develop. Late infections occurring > 180 days after the transplant can be due to latent pathogens or community-acquired organisms. Approaching an infectious evaluation in a pediatric kidney recipient requires finesse to diagnose and treat this vulnerable population in a timely manner. The following article highlights the most relevant and common infections including clinical manifestations, risk factors, diagnostic techniques, and treatment options.

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Infections Following Kidney Transplant in Children: A Single-Center Study

Cited by 6 publications

References 17 publications

Organisms Isolated and Their Antibiotic Sensitivity Pattern from Renal Transplant Recepients in Kidney Transplant Unit

Organisms Isolated and Their Antibiotic Sensitivity Pattern from Renal Transplant Recepients in Kidney Transplant Unit

Severe infections in kidney transplanted children

Infectious disease risks in pediatric renal transplantation

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