Infections and solid organ transplant rejection: a cause-and-effect relationship?

Cainelli, Francesca; Vento, Sandro

doi:10.1016/s1473-3099(02)00370-5

Cited by 153 publications

(109 citation statements)

References 116 publications

Supporting

Mentioning

102

Contrasting

Unclassified

Order By: Relevance

“…A range of acute viral infections, most particularly herpesvirus infections, has been linked with initiating the clinical complications that often follow transplantations. In bone marrow transplant recipients, HCMV infection is associated with graft-vshost disease, and in solid organ transplant settings, it is associated with a higher incidence of both acute and chronic rejection (37,38). The association between hepesvirus infection and allograft rejection is most probably due to cross-reactivity of herpesvirusspecific T cells toward allogeneic MHC molecules.…”

Section: Discussionmentioning

confidence: 99%

EBV-Specific CD4+ T Cell Clones Exhibit Vigorous Allogeneic Responses

Landais

Morice

Long

et al. 2006

The Journal of Immunology

View full text Add to dashboard Cite

Alloreactive T cells play a key role in mediating graft-vs-host disease and allograft rejection, and recent data suggest that most T cell alloreactivity resides within the CD4 T cell subset. Particularly, T cell responses to herpesvirus can shape the alloreactive repertoire and influence transplantation outcomes. In this study, we describe six distinct EBV-specific CD4+ T cell clones that cross-reacted with EBV-transformed lymphoblastoid cell lines (LCLs), dendritic cells, and endothelial cells expressing MHC class II alleles commonly found in the population. Allorecognition showed exquisite MHC specificity. These CD4+ T cell clones efficiently killed dendritic cells or LCLs expressing the cross-reactive allogeneic MHC class II molecules, whereas they did not kill autologous LCLs. Endothelial cells expressing the proper allogeneic MHC molecules were poorly killed, but they induced high-level TNF-α production by the EBV-specific CD4+ T cell clones. As already proposed, the strong alloreactivity toward LCLs suggest that these cells could be used for selective depletion of alloreactive T cells.

show abstract

Section: Discussionmentioning

confidence: 99%

EBV-Specific CD4+ T Cell Clones Exhibit Vigorous Allogeneic Responses

Landais

Morice

Long

et al. 2006

The Journal of Immunology

View full text Add to dashboard Cite

show abstract

“…The number of patients with CMV infection increases with the development of immunodepressive agents, such as anti-CD3 monoclonal antibody (OKT3) or antihuman thymocyte globulin (ATG), which are used in steroid-resistant acute rejection or induction therapy immediately after transplantation. Furthermore, CMV infection is one of the important factors influencing successful renal transplantation, because it affects immune function and is closely related to acute and chronic postoperative rejection, leading to renal allograft failure (Cainelli and Vento, 2002;Tong et al, 2002;Lautenschlager et al, 1999). Some studies have revealed that CMV disease is an independent risk factor for acute rejection in kidney allograft recipients (Krogerus et al, 2008;Sagedal et al, 2002;Toupance et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Allograft rejection-related gene expression in the endothelial cells of renal transplantation recipients after cytomegalovirus infection

Yang

Xue

et al. 2009

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

Abstract:Objective: To explore the effects of cytomegalovirus (CMV) infection on rejection-related gene expression in the endothelial cells of renal transplantation recipients. Methods: Endothelial cells (ECs) were cultured and stimulated by a variety of factors: A, normal control group; B, inactivated human cytomegalovirus (HCMV) infection group; C, HCMV infection group; D, HCMV supernatant infection group; and E, ganciclovir HCMV group. Expression of intercellular adhesion molecule-1 (ICAM-1) and major histocompability complex (MHC) class I and class II antigens was detected by flow cytometry (FCM) and immunohistochemistry. Results: We found characteristic CMV-infected ECs in this study. There were no significant differences among groups A, B and D (P>0.05). Although the expression levels of ICAM-1 were not significantly different between groups C and E (P>0.05), the ICAM-1 expression in these two groups was significantly higher than that in group A (P<0.05). ICAM-1 expression was detected in groups C and E, while there was no expression in groups A, B and D. Furthermore, there was no significant difference of ICAM-1 mRNA expression between groups C and E (P>0.05). Human leucocyte antigen (HLA)-ABC expression was detected in all the groups, while HLA-DR expression was only detected in groups C and E. There were no significant differences of HLA-ABC and HLA-DR expression among groups A, B and D (P>0.05). However, the HLA-ABC and HLA-DR expression levels in groups C and D were higher than those of the remaining groups previously reported (P<0.05). Meanwhile, the HLA-ABC and HLA-DR expression levels in group E were lower than those of group C (P<0.05). Conclusion: CMV could up-regulate the expression levels of ICAM-1 and MHC antigens, which was closely related to allograft rejection.

show abstract

“…[18][19][20][21][22] An analogy can be made to the relationship in native renal disease between infection and autoimmune GN. 23 Figure 4 is a pictorial representation of these relationships.…”

Section: Discussionmentioning

confidence: 99%

“…Both primary infection and reactivation of latent viral disease have been associated with allograft rejection; however, the correlation is complex, and the cause and effect relationship has still not been established. [18][19][20][21][22]27 Analysis of the histology from patients with rejection and coexisting acute viral infection, of which cytomegalovirus (CMV) and Epstein-Barr virus (EBV) have both been studied, shows a correlation with C4d positivity and the development of chronic allograft nephropathy, but these reports do not include ultrastructural examination for TRIs. 27 Independently, it has been shown that infection with CMV can lead to the development of antiendothelial cell antibodies in recipients of renal transplants and recipients of cardiac transplants.…”

Section: Discussionmentioning

confidence: 99%

Tubuloreticular Inclusions in Renal Allografts Associate with Viral Infections and Donor-Specific Antibodies

Willicombe

Moss

Moran

et al. 2015

JASN

View full text Add to dashboard Cite

The presence of tubuloreticular inclusions (TRIs) in native glomerular endothelial cells associates with viral infections and lupus nephritis. However, the associations of TRIs in renal transplant biopsy specimens are not known. We analyzed data from 316 patients who had a transplant biopsy with electron microscopy examination; 41 of 316 (13.0%) patients had TRIs. Patients with TRIs had significantly lower allograft survival rates (50.9%) than patients without TRIs (74.3%; P=0.03). Transplant glomerulopathy-free survival was also inferior in the TRI-positive group (57.5%) compared with the TRI-negative group (87.3%; P=0.002). Serologically, hepatitis C associated with the presence of TRIs (P=0.04) along with donorspecific antibodies (P=0.01). Furthermore, patients who were TRI positive were more likely than patients who were TRI negative to have had a previous rejection episode (P=0.02). On multivariate analysis, TRIs associated with prior rejection, viral infections, and class 1 HLA donor-specific antibodies. These results show that the presence of TRIs in renal allograft biopsy specimens associates with poor allograft outcomes and serologic evidence of viral infections and alloimmunity. The association with alloimmunity is a novel finding that warrants additional investigation.

show abstract

Infections and solid organ transplant rejection: a cause-and-effect relationship?

Cited by 153 publications

References 116 publications

EBV-Specific CD4+ T Cell Clones Exhibit Vigorous Allogeneic Responses

EBV-Specific CD4+ T Cell Clones Exhibit Vigorous Allogeneic Responses

Allograft rejection-related gene expression in the endothelial cells of renal transplantation recipients after cytomegalovirus infection

Tubuloreticular Inclusions in Renal Allografts Associate with Viral Infections and Donor-Specific Antibodies

Contact Info

Product

Resources

About