Infections and glaucoma

Aldaas, Khalid M.; Challa, Pratap; Weber, David J.; Fleischman, David

doi:10.1016/j.survophthal.2021.08.009

“…Loss of corneal endothelial cells can be brought on by corneal injury and various surgical procedures. Bullae keratopathy occurs when there are 10 to 15% fewer corneal endothelial cells than normal [ 41 ]. The results demonstrated that there was no significant heterogeneity in corneal endothelial cell counts after IOL treatment compared to before treatment (MD = 225.08, 95% CI: -64.17 to -514.33; Z = 1.53, P = 0.13), indicating that the loss of corneal endothelial cells in glaucoma patients was not significant after IOL treatment, thereby decreasing the likelihood of bullae keratopathy.…”

Section: Discussionmentioning

confidence: 99%

Meta-Analysis of the Comprehensive Efficacy of Intraocular Lens Implantation in Glaucoma Patients

Zhou

¹

2022

BioMed Research International

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This study is aimed at investigating the efficacy of intraocular lens (IOL) implantation in patients suffering from glaucoma through meta-analysis of the previously published research. For this purpose, different literature databases were searched for identification of clinical studies published between January 2000 and January 2022 on evaluating IOL’s efficacy in treating glaucoma. RevMan 5.3 was used to conduct a meta-analysis of the pertinent data. The central anterior chamber depth (ACD), corneal endothelial cell counts, best-corrected visual acuity (BCVA), intraocular pressure (IOP), anti-glaucoma medications (AGM), and axial length (AL) changes were compared, and the incidence of postoperative complications was thoroughly evaluated. The Cochran chi-square test was used to examine the heterogeneity of the evaluation results. According to the inclusion and exclusion criteria, 20 studies included 948 glaucomatous eyes. IOP was significantly lower than before treatment ( MD = 8.64 , 95 CI: 5.75-11.53; Z = 5.86 , P < 0.0001 ), while ACD increased significantly ( MD = − 1.38 , 95 percent CI: -1.74-1.02; Z = 7.49 , P < 0.0001 ). The corneal endothelial cell counts were homogeneous ( MD = 225.08 , 95% CI: -64.17 to -514.33; Z = 1.53 , P = 0.20 ). AGM utilisation decreased ( MD = 1.43 , 95% CI: 0.752.12, Z = 4.09 , P < 0.0001 ). AL decreased significantly ( MD = 0.31 ; 95% CI: 0.09-0.54; Z = 2.71 ; P = 0.007 ). The incidence of complications remained insignificant after IOL treatment ( OR = 1.05 , 95% CI: 0.42 to 2.60; Z = 0.10 , P = 0.92 ; P = 0.92 ). These findings indicate that IOL treatment can significantly reduce intraocular pressure, glaucoma drug use, and aqueous level (AL) in glaucoma patients while increasing the depth of the central anterior chamber. This study offers a theoretical foundation for selecting glaucoma treatment methods.

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“…Since intraocular pressure elevation is one of the strongest glaucoma’s risk factors that may be affect by hypertension [ 16 , 19 ], we also explored the effect of dietary Ca, K, and Mg intake on glaucoma in non-hypertension and hypertension patients.…”

Section: Resultsmentioning

confidence: 99%

“…Studies have indicated that increased levels of oxidative damage markers and reduced antioxidant potential in various ocular tissues of glaucoma patients [ 42 , 43 ]. In addition, elevated intraocular pressure is considered a major risk factor for the incidence and/or progression of POAG [ 19 ]. Study demonstrated that Ca dysregulation results in the wild-type myocilin misfolding initially and may further contribute broadly to glaucoma-associated endoplasmic reticulum stress [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, recent studies remaindered that hypertension is associated with the increased eye pressure that could furthermore affect the occurrence and development of glaucoma [16][17][18]. Intraocular pressure elevation is among glaucoma's strongest risk factors [19]. And there were significant differences in oxidative stress and blood flow between patients with hypertension and that non-hypertensive [20].…”

Section: Introductionmentioning

confidence: 99%

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Association between dietary calcium, potassium, and magnesium consumption and glaucoma

Zhang,

Zhao,

Ma

et al. 2023

PLoS ONE

2

0

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Background Calcium (Ca), potassium (K) and magnesium (Mg) may be involved in the occurrence and development of glaucoma by influencing the retinal oxidative stress and regulate blood pressure. However, epidemiological opinions on dietary intake of macroelement related to glaucoma are inconsistent. Herein, this study aims to explore the association between dietary Ca, K, and Mg consumption and glaucoma. Methods Data of 7,042 adults aged ≥40 years old who received the glaucoma examinations were extracted from the National Health and Nutrition Examination Survey (NHANES) database from 2005 to 2008 in this cross-sectional study. Univariate and multivariate logistic regression were used to explore the association between dietary Ca, K, and Mg intake and glaucoma with the odd ratios (ORs) and 95% confidence intervals (CIs). We also investigated this relationship in individuals of different age, with/without hypertension and visual field defect (VFD). Results There were 502 (8.11%) participants had glaucoma. After adjusted for covariables, we found that enough dietary Ca consumption was related to a decreased risk of glaucoma [OR = 0.59, 95%CI: (0.42–0.81)], whether in persons with/without hypertension (all P<0.05). In particular, dietary K intake may be a potential protect factor for glaucoma in non-hypertension populations [OR = 0.47, 95%CI: (0.22–0.99), P = 0.049]. Additionally, hypertension/non-hypertension persons who aged <65 years old or with/without VFD should all pay attention to the enough dietary supplement of Ca, K, and Mg according to their own circumstances. Conclusion Enough dietary Ca, K, and Mg consumption may be potential protect factors of glaucoma that could provide some dietary reference for developing targeted glaucoma prevention and control measures.

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“…The hypothesis of the correlation between H. pylori infection and glaucoma originated from the role of H. pylori causing the release of various pro-inflammatory and vasoactive substances, arteriosclerosis-induced increased platelet activation and aggregation, and impact on the trabecular meshwork cell apoptotic process. Cross-reactivity between antibodies to Helicobacter pylori and the ciliary epithelium has also been speculated [18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Association between helicobacter pylori infection and primary open-angle glaucoma: a systematic review and meta-analysis

Ezzati Amini,

Moradi

2023

BMC Ophthalmol

4

0

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Purpose This systematic review and meta-analysis summarize the evidence for the association between Helicobacter pylori infection and Primary Open-Angle Glaucoma. Methods Eligible studies reporting an association between H. pylori infection and Glaucoma were identified through an extensive search of the Excerpta Medica (EMBASE), Web of Science, Scopus, and PubMed databases and an assessment of the reference list of the top articles until October 2022. Analysis was performed with random effects model using Stata 16. Result Twenty-four studies were included in the systematic review. This study involved 1602 glaucoma patients and 2800 control individuals. The combined RRs of cohort studies and overall combined ORs of case-control studies showed a significant correlation between H. pylori infection and Glaucoma. Subgroup analysis showed that glaucoma patients had a higher risk of having H. pylori infection if they were residents of Europe countries (Cohort: RR: 1.69; 95% CI: 1.3–2.19) and (Case-Control: RR: 3.71; 95% CI: 2.07–6.64), if they had POAG type (Cohort: RR: 1.76; 95% CI: 1.37–2.27) and (Case-Control: RR: 3.71; 95% CI: 2.934.70), if their diagnostic method of HP was histology (Cohort: RR: 1.95; 95% CI: 1.26–3.01) and (Case-Control: RR: 4.06; 95% CI: 2.28–7.22), and if they were over 60 years old (Cohort: RR: 1.63; 95% CI: 1.33-2.00) and (Case-Control: RR: 2.95; 95% CI: 2.27–3.83). Discussion The results of this meta-analysis suggest a statistically significant association between Helicobacter pylori infection and Primary Open-Angle Glaucoma.

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Infections and glaucoma

Cited by 7 publications

References 180 publications

Meta-Analysis of the Comprehensive Efficacy of Intraocular Lens Implantation in Glaucoma Patients

Meta-Analysis of the Comprehensive Efficacy of Intraocular Lens Implantation in Glaucoma Patients

Association between dietary calcium, potassium, and magnesium consumption and glaucoma

Association between helicobacter pylori infection and primary open-angle glaucoma: a systematic review and meta-analysis

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