Infections and Acute Lymphoblastic Leukemia: Is the Sum Worth More than the Parts? Evidence from Birth Characteristics

Gallant, Rachel

doi:10.1158/1055-9965.epi-22-1257

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…To date, few risk factors have been found to be associated with childhood leukemia and explain less than 10% of the causes of the disease ( 8 ). One of the regions of Mexico which has been explored further in previous studies is Greater Mexico City (GMC) where it has been reported that the incidence of AL is among the highest in the world ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of childhood acute leukemias in marginalized populations of the central-south region of Mexico: results from a population-based registry

Flores-Lujano,

Allende-López,

Duarte-Rodríguez

et al. 2024

Front. Oncol.

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IntroductionAcute leukemias (AL) are the main types of cancer in children worldwide. In Mexico, they represent one of the main causes of death in children under 20 years of age. Most of the studies on the incidence of AL in Mexico have been developed in the urban context of Greater Mexico City and no previous studies have been conducted in the central-south of the country through a population-based study. The aim of the present work was to identify the general and specific incidence rates of pediatric AL in three states of the south-central region of Mexico considered as some of the marginalized populations of Mexico (Puebla, Tlaxcala, and Oaxaca).MethodsA population-based study was conducted. Children aged less than 20 years, resident in these states, and newly diagnosed with AL in public/private hospitals during the period 2021-2022 were identified. Crude incidence rates (cIR), standardized incidence rates (ASIRw), and incidence rates by state subregions (ASIRsr) were calculated. Rates were calculated using the direct and indirect method and reported per million children under 20 years of age. In addition, specific rates were calculated by age group, sex, leukemia subtype, and immunophenotype.ResultsA total of 388 cases with AL were registered. In the three states, the ASIRw for AL was 51.5 cases per million (0-14 years); in Puebla, it was 53.2, Tlaxcala 54.7, and Oaxaca de 47.7. In the age group between 0-19 years, the ASIRw were 44.3, 46.4, 48.2, and 49.6, in Puebla, Tlaxcala, and Oaxaca, respectively. B-cell acute lymphoblastic leukemia was the most common subtype across the three states.ConclusionThe incidence of childhood AL in the central-south region of Mexico is within the range of rates reported in other populations of Latin American origin. Two incidence peaks were identified for lymphoblastic and myeloid leukemias. In addition, differences in the incidence of the disease were observed among state subregions which could be attributed to social factors linked to the ethnic origin of the inhabitants. Nonetheless, this hypothesis requires further investigation.

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Section: Introductionmentioning

confidence: 99%

Epidemiology of childhood acute leukemias in marginalized populations of the central-south region of Mexico: results from a population-based registry

Flores-Lujano,

Allende-López,

Duarte-Rodríguez

et al. 2024

Front. Oncol.

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Not All Populations of Hispanic Children Have an Increased Frequency of Acute Lymphoblastic Leukemia

Mejı́a-Aranguré

Núñez-Enríquez

2023

Cancer Epidemiology, Biomarkers &Amp; Prevention

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The frequency of acute lymphoblastic leukemia (ALL) has been reported with a higher incidence among the populations of Hispanic children. However, in the article by Montes-Rodríguez and colleagues, they found that in the Puerto Rican population, the frequency was below the incidence reported for the U.S. Hispanic pediatric population, but they found that the incidence of ALL had an annual increase of 5%. In other Hispanic pediatric populations during the 1980s, the incidence of ALL was found to be even lower than the general rate in the United States. However, in less than 20 years that incidence had already been exceeded. It is evident that the Hispanic pediatric population is more susceptible to develop ALL than other populations, so it is important to consider that what is happening to the pediatric population of Puerto Rico gives us a great opportunity to identify risk factors that could potentially explain this increase. It is more likely that the risk factors that are capable of causing ALL could be identified in their role in the origin of the disease in populations with high susceptibility, given the greater number of cases of ALL that said factor is causing in that population. See related article by Montes-Rodríguez et al., p. 1030

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Infections and Acute Lymphoblastic Leukemia: Is the Sum Worth More than the Parts? Evidence from Birth Characteristics

Cited by 2 publications

References 22 publications

Epidemiology of childhood acute leukemias in marginalized populations of the central-south region of Mexico: results from a population-based registry

Epidemiology of childhood acute leukemias in marginalized populations of the central-south region of Mexico: results from a population-based registry

Not All Populations of Hispanic Children Have an Increased Frequency of Acute Lymphoblastic Leukemia

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