Infections à Staphylocoque lugdunensis sur prothèses articulaires

Lecuire, F; Gontier, D.; Carrère, Jacqueline; Basso, Marianne; Benareau, I.; Rubini, J

doi:10.1016/s0035-1040(07)90209-3

Cited by 4 publications

(1 citation statement)

References 7 publications

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“…[21]6Lecuire et al. [22]7(34-86)From 6 wk up to 9 y and 8 mo4 TKR, 3 THRTrampuz et al [23]3Shah et al. [2]28(35-88)14 M, 14 F3 DM, 5 on steroids, 9 urogenital abnormalities25 TKR, 3 THRHarris et al.…”

Section: Discussionmentioning

confidence: 99%

Small-colony variant of Staphylococcus lugdunensis in prosthetic joint infection

2018

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Prosthetic joint infection is usually caused by staphylococci. Among the coagulase-negative staphylococci, Staphylococcus lugdunensis is important because it behaves as a pathogen similar to S aureus. It also develops biofilms, and the biofilm phenotype can appear as small-colony variants. Although genetically indistinguishable, they differ in size and antibiotic susceptibility from the parent strain and are responsible for chronic persistent infection and failure of antibiotic treatment. They can also lead to misinterpretation of results. The patient reported here underwent total knee replacement and 2 years later presented with prosthetic joint infection. Tissue samples and prosthesis taken at revision grew S lugdunensis, the majority of which were small-colony variants. Recommendations are made for their detection and identification.

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Section: Discussionmentioning

confidence: 99%

Small-colony variant of Staphylococcus lugdunensis in prosthetic joint infection

2018

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Bone and Joint Infections Caused by Staphylococcus lugdunensis

Karnani¹,

Myers²

2008

Infectious Diseases in Clinical Practice

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Clinical Characteristics and Outcomes of Staphylococcus lugdunensis Prosthetic Joint Infections: A Multicenter Retrospective Analysis

Masood¹,

Redfern²,

Duggan³

et al. 2020

Orthopedics

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Staphylococcus lugdunensis has been increasingly recognized as a cause of serious infections, particularly prosthetic joint infections (PJIs). The aim of this study was to describe the clinical characteristics, treatments, and outcomes of S lugdunensis PJIs. This was a retrospective multicenter study of consecutive adult patients with S lugdunensis PJIs from January 2007 through December 2017; 28 patients met inclusion criteria. The knee was the most commonly affected joint (67.9%), followed by the hip (25%). Clinical and microbiologic characteristics, treatment modalities, and outcomes were evaluated. Thirteen (46.4%) patients had two-stage revision, 9 (32.1%) had debridement with or without revision, 5 (21.4%) had no surgical intervention, and 1 (3.6%) had one-stage revision. Twenty-four (85.7%) patients had monomicrobial infection with S lugdunensis , whereas 4 had polymicrobial. Two patients had concomitant bacteremia. All isolates, except 1, were susceptible to oxacillin. Three patients with no surgical intervention received oral antibiotics, 2 were not treated, and 1 was discharged to hospice. Relapse was observed in 2 of 13 (15%) patients who had two-stage revision, 4 of 9 (44%) who had debridement, and 6 of 6 (100%) who had no surgical intervention or one-stage revision regardless of antibiotic treatment regimen. There was a significant difference in cure rate for patients who underwent two-stage revision compared with other treatment modalities (85% vs 33%, P =.009). Appropriate management of S lugdunensis PJI includes both aggressive surgical treatment and a prolonged course of antibiotics and is associated with excellent clinical response. Regardless of route or duration of antibiotic therapy, relapse is high for patients not treated with two-stage revision. [ Orthopedics . 2020;43(6):345–350.]

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Infections à Staphylocoque lugdunensis sur prothèses articulaires

Cited by 4 publications

References 7 publications

Small-colony variant of Staphylococcus lugdunensis in prosthetic joint infection

Small-colony variant of Staphylococcus lugdunensis in prosthetic joint infection

Bone and Joint Infections Caused by Staphylococcus lugdunensis

Clinical Characteristics and Outcomes of Staphylococcus lugdunensis Prosthetic Joint Infections: A Multicenter Retrospective Analysis

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