Infection with Specific Helicobacter pylori-cag Pathogenicity Island Strains Is Associated with Interleukin-1B Gene Polymorphisms in Venezuelan Chronic Gastritis Patients

Chiurillo, Miguel Ángel; Moran, Yeinmy; Cañas, Miryan; Valderrama, Elvis; Armanie, Emma

doi:10.1007/s10620-010-1316-0

Cited by 14 publications

(11 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies of our group suggested a synergism between H. pylori virulence factors and host genetic variants of the pro-inflammatory cytokine IL-1 on the development of severe chronic gastritis in Venezuela [23,40]. Moreover, recent studies have reported pro-inflammatory and prooncogenic activities independent of phosphorylation of CagA EPIYA motifs that may be relevant to gastric disease incidence [32,34,41].…”

Section: Atrophic Gastritismentioning

confidence: 70%

“…Moreover, in previous studies although we have observed a high prevalence of H. pylori cagA-positive strains (70.6e79.3%) no correlation was found with the severity of chronic gastritis in Venezuelan patients [23,24]. In this work, we have evaluated the number and type of EPIYA motifs to try to assess whether they are pathogenicity markers for H. pylori strains involved in cases of chronic gastritis in the country.…”

Section: Introductionmentioning

confidence: 94%

See 1 more Smart Citation

Study of the oipA genetic diversity and EPIYA motif patterns in cagA-positive Helicobacter pylori strains from Venezuelan patients with chronic gastritis

Torres

Valderrama²,

Sayegh

et al. 2014

Microbial Pathogenesis

Self Cite

View full text Add to dashboard Cite

Section: Atrophic Gastritismentioning

confidence: 70%

Section: Introductionmentioning

confidence: 94%

Study of the oipA genetic diversity and EPIYA motif patterns in cagA-positive Helicobacter pylori strains from Venezuelan patients with chronic gastritis

Torres

Valderrama²,

Sayegh

et al. 2014

Microbial Pathogenesis

Self Cite

View full text Add to dashboard Cite

“…The risk for gastric cancer development may further increase if the host polymorphisms responsible for a higher probability of the disease combine with more aggressive bacterial virulence factors [62,63]. …”

Section: Host Geneticsmentioning

confidence: 99%

Markers for Gastric Cancer Premalignant Lesions: Where Do We Go?

Leja

Wex²,

Malfertheiner³

2012

Dig Dis

View full text Add to dashboard Cite

Only a small proportion of patients infected with Helicobacter pylori develop gastric cancer during their lifetime. At the same time, this type of cancer remains an important cause of mortality globally. The current interventional strategies have not been successful in decreasing the global burden of the disease; therefore, biomarkers for the identification of the individuals at high risk as well as those in the early stage of the disease is of high importance. In addition, predicting the point of no return for the development of the malignancy is of particular interest; whether atrophy, intestinal or spasmolytic polypeptide-expressing metaplasia, or some of their subtypes correspond to this point, still needs to be answered. The current review addresses the place of ‘old markers’, in particular pepsinogen tests for the identification of increased risk conditions. More data in Caucasian populations are required before these tests can be recommended for routine screening. Several of the host genetic factors are related to the development of sporadic gastric cancer; still their importance is probably not so high as initially thought, and at this stage host genetic factors cannot be used to identify high-risk groups. The detection of specific microRNAs could become a potential field in marker development, and several other new approaches for marker identification are emerging. To achieve the goal, a screening marker has to be not only accurate, but also available and cost-effective in the target populations, many of which are from low-income countries. This has to be considered when developing a marker or set of markers offered for gastric cancer screening programs.

show abstract

“…5 In Venezuela, the prevalence of gastric infection by H. pylori has been reported ranging from 38% to 95% in the asymptomatic and symptomatic population in different localities, by using different detection methods. [6][7][8] In our laboratory, we have validated the detection of H. pylori by polymerase chain reaction (PCR) in string-absorbed gastric juice compared with gastroesophageal biopsies obtained by endoscopy in an urban population from Caracas. These studies showed that the string-absorbed gastric juice test is as sensitive as detection in gastroesophageal biopsies taken by endoscopy, allowing an accurate diagnosis of H. pylori infection by a less invasive method, 9-11 as was also validated in Lima, Perú by Velapatiño and others.…”

mentioning

confidence: 99%

Helicobacter pylori Infection in Rural and Urban Dyspeptic Patients from Venezuela

Contreras

Fernández-Delgado

Reyes

et al. 2015

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. The goal of this work was to assess the Helicobacter pylori prevalence in a rural mestizo population and compare it to an urban population from Venezuela. The study was performed in gastric juice samples of 71 dyspeptic patients from Caracas (urban) and 39 from Tucupita (rural), in the Orinoco Delta region. Helicobacter pylori was detected by amplification of 16S rRNA, glmM, and ureA genes in 55.0% patients from urban and 87.2% from rural populations. cagA was found positive in 51% and 62% urban and rural patients, respectively. Non-H. pylori Helicobacter species were not detected in the urban population, but was found in 7.7% of patients in the rural study site. Frequency values of the 16S rRNA, glmM, and ureA genes were higher in the rural population. The odds ratio for each gene was 15.18 for 16S rRNA, 2.34 for glmM, 2.89 for ureA, and 1.53 cagA, showing significant differences except for cagA when gene frequency was compared in both populations. These results demonstrate a higher frequency of H. pylori and gastric non-H. pylori Helicobacter infection in a rural mestizo population with low hygienic standards as compared with city dwellers, representing a potential risk for the development of gastroduodenal diseases.

show abstract

Infection with Specific Helicobacter pylori-cag Pathogenicity Island Strains Is Associated with Interleukin-1B Gene Polymorphisms in Venezuelan Chronic Gastritis Patients

Cited by 14 publications

References 45 publications

Study of the oipA genetic diversity and EPIYA motif patterns in cagA-positive Helicobacter pylori strains from Venezuelan patients with chronic gastritis

Study of the oipA genetic diversity and EPIYA motif patterns in cagA-positive Helicobacter pylori strains from Venezuelan patients with chronic gastritis

Markers for Gastric Cancer Premalignant Lesions: Where Do We Go?

Helicobacter pylori Infection in Rural and Urban Dyspeptic Patients from Venezuela

Contact Info

Product

Resources

About