Infection with Simkania negevensis in Brooklyn, New York

Kumar, Swati; Kohlhoff, Stephan; Gelling, Maureen; Roblin, Patricia M.; Kutlin, Andrei; Kahane, S.; Friedman, Maureen G.; Hammerschlag, Margaret R.

doi:10.1097/01.inf.0000183755.24578.0b

Cited by 32 publications

(30 citation statements)

References 19 publications

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“…Serological evidence of past infection was documented in 46% of pregnant women in Cornwall, UK (Friedman et al, 2006) and in 41% of Danish blood donors (Johnsen et al, 2005). In contrast, an overall prevalence of only 23.5% was observed among children and adults in Brooklyn, USA (Kumar et al, 2005) and only 4.5% of the population tested in Japan were seropositive, a low prevalence observed despite the low cutoff titer of 1:8 used in the study (Yamaguchi et al, 2005). The large discrepancy between these results could be explained by geographical differences in term of exposure and risk factors.…”

Section: Prevalencecontrasting

confidence: 52%

Simkania negevensis, an insight into the biology and clinical importance of a novel member of the Chlamydiales order

Vouga

Baud

Greub

2016

Critical Reviews in Microbiology

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Simkania negevensis is a Chlamydia-related bacterium discovered in 1993 and represents the founding member of the Simkaniaceae family within the Chlamydiales order. As other Chlamydiales, it is an obligate intracellular bacterium characterized by a biphasic developmental cycle. Its similarities with the pathogenic Chlamydia trachomatis and Chlamydia pneumoniae make it an interesting bacterium. So far, little is known about its biology, but S. negevensis harbors various microbiological characteristics of interest, including a strong association of the Simkania-containing vacuole with the ER and the presence of an intron in the 23S rRNA encoding gene. Evidence of human exposition has been reported worldwide. However, there is a lack of robust clinical studies evaluating its implication in human diseases; current data suggest an association with pneumonia and bronchiolitis making S. negevensis a potential emerging pathogen. Owing to its fastidious growth requirements, the clinical relevance of S. negevensis is probably underestimated. In this review, we summarize the current knowledge on S. negevensis and explore future research challenges. ARTICLE HISTORY

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Section: Prevalencecontrasting

confidence: 52%

Simkania negevensis, an insight into the biology and clinical importance of a novel member of the Chlamydiales order

Vouga

Baud

Greub

2016

Critical Reviews in Microbiology

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“…Greenberg et al [9] reported that they identifi ed a positivity rate of 64% for S. negevensis with the PCR method on the specimens taken from 22 infants with bronchiolitis in Canada [9]. In a study conducted by Kumar et al [2] in Brooklyn, NY, S. negevensis was researched in a group of patients consisting of 188 children and adults (aged between 2 weeks-83 years) diagnosed with asthma, bronchiolitis and pneumonia. A control group of 110 healthy subjects who were of similar age was also included.…”

Section: Discussionmentioning

confidence: 99%

“…A control group of 110 healthy subjects who were of similar age was also included. It was reported that S. negevensis was detected in 17% of the patients and 23% of the control group in the nasopharyngeal swab material with the PCR method [2]. In a study by Korppi et al [10], which was conducted in Finland, they searched for S. negevensis in a group of 104 patients with recent diagnosis of asthma who were aged between 1-6 years.…”

Section: Discussionmentioning

confidence: 99%

“…It has been recommended that S. negevensis, formerly called "Z" or "Simkania Z", be named as a new family under Simkaniacea. Along with the globally varying seroprevalence of S. negevensis, there exists a high rate of seropositivity for some populations and it is associated with various respiratory diseases [2]. S. negevensis has been proven to have an association with acute bronchiolitis [3], community-acquired pneumonia in adults [4] and acute exacerbation of chronic obstructive pulmonary disease (COPD) [5].…”

Section: Introductionmentioning

confidence: 99%

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Simkania negevensis: Is it a real respiratory pathogen?

Köse

Ekinci

Gökahmetoğlu

et al. 2015

Acta Microbiologica et Immunologica Hungarica

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Simkania negevensis, a recently discovered Chlamydia-like organism, has been associated with respiratory infections such as pneumonia, bronchiolitis and chronic obstructive pulmonary disease in children and adults. The aim of the present study was to evaluate S. negevensis in the etiology of pediatric community-acquired pneumonia, bronchiolitis and asthma exacerbation in our region. Overall, 102 patients and 46 healthy controls were included in the study. S. negevensis was investigated by real time PCR (Primer Design, UK) in nasopharyngeal swab samples. It failed to be detected in either the study or control group. In conclusion, our results suggest that S. negevensis is not an important respiratory pathogen in our region.

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“…Serological evidence of past exposure to S. negevensis has been well documented, indicating that natural infection with this pathogenic microorganism seems to be highly prevalent worldwide Kumar et al 2005;Yamaguchi et al 2005;Baud et al 2009). Recently, it has been suggested that S. negevensis could be a ubiquitous microorganism present in most aquatic habitats such as drinking water and reclaimed wastewater because of its relative resistance to chlorination (Kahane et al 2004(Kahane et al , 2007 and its ability to replicate and survive over long periods of time in amoebic cysts (Kahane et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Prevalence study of Simkania negevensis in cooling towers in Spain

Pérez

Codony

Rìos

et al. 2010

Journal of Water and Health

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Simkania negevensis is an obligate intracellular bacterium grouped into the order Chlamydiales.This new amoeba-resistant intracellular bacterium might represent a novel etiologic agent of bronchiolitis and community-acquired pneumonia and occurs in aquatic habitats such as drinking water and reclaimed wastewater. Another amoeba-related bacterium, Legionella pneumophila, is an etiologic agent of pneumonia transmitted by environmental aerosols or contaminated water/air cooling systems. These transmission pathways are important in the natural history of Legionellae infections and possibly other intracellular microorganisms such as Parachlamydiaceae; thus, understanding the feasibility of Simkania infection by these routes is relevant. In the present work, we investigated the prevalence of this newly identified pathogenic bacterium in cooling towers by quantitative PCR (qPCR) and its possible relationship with Legionella pneumophila co-infection. Our results show Simkania detection in 2 of 70 cooling towers analyzed. To our knowledge, this report is the first describing Simkania negevensis detection in this category of environmental water samples.

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Infection with Simkania negevensis in Brooklyn, New York

Abstract: S. negevensis was not a significant respiratory pathogen in Brooklyn, NY, during the period of the study.

Cited by 32 publications

References 19 publications

Simkania negevensis, an insight into the biology and clinical importance of a novel member of the Chlamydiales order

Simkania negevensis, an insight into the biology and clinical importance of a novel member of the Chlamydiales order

Simkania negevensis: Is it a real respiratory pathogen?

Prevalence study of Simkania negevensis in cooling towers in Spain

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