2020
DOI: 10.21203/rs.2.25200/v1
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Infection with Novel Coronavirus (SARS-CoV-2) Causes Pneumonia in the Rhesus Macaques

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Cited by 81 publications
(102 citation statements)
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“…Experimental infection with SARS-CoV-2 in these models provides basic information to address a number of fundamental questions regarding its pathogenicity, the interaction with the different hosts and, hopefully, establishing the criteria for prevention and care. In line with observations in SARS models, non-human primates and wild-type mice infected with SARS-CoV-2 exhibit a relatively mild clinical disease, in spite of the evidence that Quantitative reverse transcription polymerase chain reaction (RT-qPCR) revealed a massive infection of the respiratory tract [44,45] (Table 2). Rhesus macaques infected with bronchoalveolar lavage fluid obtained from an affected patient developed a histopathologically confirmed interstitial pneumonia, associated with a widespread presence of SARS-CoV-2 in the respiratory tract.…”
Section: Organ Tropism and Neuroinfective Routessupporting
confidence: 73%
See 1 more Smart Citation
“…Experimental infection with SARS-CoV-2 in these models provides basic information to address a number of fundamental questions regarding its pathogenicity, the interaction with the different hosts and, hopefully, establishing the criteria for prevention and care. In line with observations in SARS models, non-human primates and wild-type mice infected with SARS-CoV-2 exhibit a relatively mild clinical disease, in spite of the evidence that Quantitative reverse transcription polymerase chain reaction (RT-qPCR) revealed a massive infection of the respiratory tract [44,45] (Table 2). Rhesus macaques infected with bronchoalveolar lavage fluid obtained from an affected patient developed a histopathologically confirmed interstitial pneumonia, associated with a widespread presence of SARS-CoV-2 in the respiratory tract.…”
Section: Organ Tropism and Neuroinfective Routessupporting
confidence: 73%
“…Rhesus macaques infected with bronchoalveolar lavage fluid obtained from an affected patient developed a histopathologically confirmed interstitial pneumonia, associated with a widespread presence of SARS-CoV-2 in the respiratory tract. Clinical signs were mild and no viral RNA was detectable by means of RT-qPCR in the blood of the primates during the whole course of infection (14 days) [44]. These findings demonstrate the causal relationship between SARS-Cov-2 and interstitial pneumonia, reminiscent of COVID-19.…”
Section: Organ Tropism and Neuroinfective Routesmentioning
confidence: 73%
“…Although the retrospective studies of COVID-19 have given us some answers 23 , further investigation also needs to be performed in various animals. So far, several animal models of COVID-19 have been reported to successfully recapitulate some aspects of this disease [5][6][7][8][9][10][11] and also indicate that these experimental animals are susceptible to SARS-CoV-2 infection.…”
Section: Histopathological Characteristics In Sars-cov-2 Infected Trementioning
confidence: 98%
“…From these points of view, studies of animals become essentially important. In fact, several animal models of COVID-19 have been recently reported in murine 5 , hamster 6 , ferret 7 , and non-human primate [8][9][10][11] , which recapitulate COVID-19 from different aspects. In terms of susceptibility to SARS-CoV-2, in addition to these experimental animals, domestic animals and pets are also investigated 12 .…”
mentioning
confidence: 99%
“…and that both viruses may have an extended host range that includes primates and other mammals (1)(2)(3) . However, the immediate source population/species for SARS-CoV and SARS-CoV-2 viruses has not yet been identified.…”
Section: Introductionmentioning
confidence: 99%