Infection withScedosporium apiospermumandS.prolificans, Australia

Abstract

S. prolificans has become a major pathogen in immunocompromised patients.

Molecular Typing of AustralianScedosporiumIsolates Showing Genetic Variability and NumerousS. aurantiacum

“…Of note, no specifi c genotypes were associated with underlying medical conditions or risk factors. Compared with S. apiospermum and S. aurantiacum S. prolifi cans was more frequently associated with coincident hospital renovation, and invasive disease, had a greater predilection to cause disseminated infection and was the predominant species isolated from blood and other sterile sites (12)(13)(14)(15)(16)36; current study). Our preliminary observations indicate that the epidemiology and clinical relevance of recovering S. aurantiacum may be similar to that of S. apiospermum.…”

“…On the basis of genetic data, a new species, S. aurantiacum, was proposed for a subset of isolates previously identifi ed as S. apiospermum (11). S. prolifi cans infections are geographically more restricted than those caused by S. apiospermum, being most prevalent in Australia, Spain, and the United States (12)(13)(14)(15). S. prolifi cans typically causes localized infections in immunocompetent hosts but rapidly fatal disseminated infections in the immunocompromised among whom it has been associated with nosocomial outbreaks (3,(12)(13)(14)(15)(16)(17).…”

“…The fi rst potential case cluster involved 8 patients located in the same hematology/hemopoietic stem cell transplant (HSCT) unit at the Alfred Hospital, a large university hospital in Melbourne (September 2000-October 2001; [15]). The second consisted of 3 patients located in the same hematology/HSCT ward at Westmead Hospital a major university hospital in Sydney (September 2003-January 2004; unpub.…”

Infección rinosinusal por Scedosporium apiospermum en un hospedero inmunocompetente

“…Scedosporium apiospermum es un hongo de distribución mundial que puede cultivarse a partir de muestras procedentes del suelo, tierra de macetas, alcantarillas, aguas estancadas, arroyos y estiércol 11 . Las patologías causadas por este oportunista van desde la colonización y reacciones alérgicas hasta infecciones localizadas y diseminadas; estas últimas pueden ser infecciones de piel y tejidos blandos, meningitis o absceso cerebral, artritis, osteomielitis, endocarditis, endoftalmitis y otras 12,15 . Las infecciones diseminadas son más frecuentes en pacientes inmunodeprimidos, especialmente en neutropénicos y aquellos que han sido sometidos a trasplantes de órganos sólidos o de precursores hematopoyéticos 16 .…”

Development and Validation of a Multiplex PCR for Detection of Scedosporium spp. in Respiratory Tract Specimens from Patients with Cystic Fibrosis

“…The emergence of Scedosporium infections in Australia has been highlighted in earlier reports describing the species distribution, clinical epidemiology, and outcomes (1,2,7,10,16). Further, a nationwide population-based study uncovered a substantial number of infections due to S. aurantiacum and identified an association between isolation of this species and the presence of chronic lung disease (16).…”