Infection with high‐risk HPV types among female sex workers in northern Vietnam

Hoang, Huyen Thi Thanh; Ishizaki, Azumi; Nguyen, Cong Tien; Tran, Vuong Thi; Matsushita, Kazuhiro; Saikawa, Kunikazu; Hosaka, Norimitsu; Pham, Hūng Viêt; Bi, Xiuqiong; Ta, Van Thanh; Pham, Thuc Van; Ishiguro, Hiroshi

doi:10.1002/jmv.23456

Cited by 19 publications

(37 citation statements)

References 43 publications

(58 reference statements)

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“…(38) In Vietnam female sex workers, high risk HPV was found in 89% of enrollees and the most common type was HPV 52 followed but HPV 16 and 18. (39) In our study, 13% of female sex workers harbored HPV, of which 7% were high-risk HPV genotypes. There was no significant difference of HPV prevalence among female sex workers and general women, suggesting that both groups have equal opportunities for screening and HPV detection and treatment.…”

Section: Discussionsupporting

confidence: 47%

“…(51) Although we do not measure cancer outcomes, our findings support previous data and similar studies that demonstrate the persistence of high-risk genotypes 16 and 18 in Thailand and in the region. (21, 39, 52) Unfortunately, neither vaccine used in Thailand is cross protective against nonspecific HPV genotypes. As such, a large proportion of people living in Thailand are susceptible to infection with HPV 31, particularly the MSM and female and MSM sex worker groups.…”

Section: Discussionmentioning

confidence: 99%

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Molecular Genotyping of Human Papillomavirus L1 Gene in Low-Risk and High-Risk Populations in Bangkok

Leaungwutiwong

Bamrungsak

Jittmittraphap

et al. 2015

Sexually Transmitted Diseases

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Background Human papillomavirus (HPV) infections in Thailand are a public health concern but information on HPV infection in sex workers and men who have sex with men (MSM) is limited. The aim of this study was to measure the prevalence and genotype distribution of HPV among low- and high-risk, HIV-negative populations. Methods A total of 300 participants were categorized as general women, female sex workers, MSM, and MSM sex workers. HPV infections were identified by the Papanicolaou (Pap) test and nested-PCR. A phylogenetic analysis of partial HPV L1 genes was performed. Results Abnormal cytology was found in 5% of general women, 10% of female sex workers, 24% of MSM and 28% of MSM sex workers. HPV was detected in 9% of general women, 13% of female sex workers and 30% in both MSM and the MSM sex workers. The prevalence of HPV high-risk genotypes was significantly higher in female sex workers and MSM while low-risk genotypes and genital warts were significantly higher in MSM sex workers. Significantly more patients with genital warts and CIN I/AIN I harbored low-risk genotypes while those with CIN II/AIN II harbored high-risk genotypes. Conclusion High- and low-risk HPV genotypes persist in high-risk groups in Bangkok. Some genotypes infecting at-risk populations are not vaccine-preventable. These findings may help to elucidate the prevalence of HPV infections in Thailand and serve as the basis for additional investigations into risk factors for these populations.

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Section: Discussionsupporting

confidence: 47%

Section: Discussionmentioning

confidence: 99%

Molecular Genotyping of Human Papillomavirus L1 Gene in Low-Risk and High-Risk Populations in Bangkok

Leaungwutiwong

Bamrungsak

Jittmittraphap

et al. 2015

Sexually Transmitted Diseases

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“…In previous studies, genomic DNA was extracted from cervical swab samples collected from female sex workers who tested positive for HPV‐16 (Japan: n = 32; the Philippines: n = 24; Vietnam: n = 25) and/or HPV‐52 (Japan: n = 42; the Philippines: n = 34; Vietnam: n = 39) [Miyashita et al, 2009; Matsushita et al, 2011; Hoang et al, 2013]. This DNA was analyzed further in the current work.…”

Section: Methodsmentioning

confidence: 99%

“…HPV‐16 and HPV‐18 account for 70% of invasive cervical cancer cases worldwide [Muñoz et al, 2003; Bouvard et al, 2009; Schiffman et al, 2009], and HPV‐16 is also most common among women with normal cytology [de Sanjosé et al, 2007; Bao et al, 2008; Bruni et al, 2010]. Although HPV‐16 has been reported to be the most prevalent type in Asia except for Japan [de Sanjosé et al, 2007; Bruni et al, 2010; Tsao et al, 2010; Chen et al, 2011a; Konno et al, 2011], recent epidemiological surveys have shown that HPV‐52 is most prevalent among female sex workers in Japan, the Philippines, and Vietnam, followed by HPV‐16 [Miyashita et al, 2009; Matsushita et al, 2011; Hoang et al, 2013].…”

Section: Introductionmentioning

confidence: 99%

E6 and E7 variants of human papillomavirus‐16 and ‐52 in Japan, the Philippines, and Vietnam

Ishizaki

Matsushita

Hoang

et al. 2013

Journal of Medical Virology

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Human papillomavirus (HPV) has several intragenotypic variants with different geographical and ethnic distributions. This study aimed to elucidate the distribution patterns of E6 and E7 (E6/E7) intragenotypic variants of HPV type 16 (HPV-16), which is most common worldwide, and HPV-52, which is common in Asian countries such as Japan, the Philippines, and Vietnam. In previous studies, genomic DNA samples extracted from cervical swabs were collected from female sex workers in these three countries and found to be positive for HPV-16 or HPV-52. Samples were amplified further for their E6/E7 genes using type-specific primers and analyzed genetically. Seventy-nine HPV-16 E6/E7 genes were analyzed successfully and grouped into three lineages: European (Prototype), European (Asian), and African-2. The prevalences of HPV-16 European (Prototype)/European (Asian) lineages were 19.4%/80.6% (n=31) in Japan, 75.0%/20.8% (n=24) in the Philippines, and 0%/95.8% (n=24) in Vietnam. The 109 HPV-52 E6/E7 genes analyzed successfully were grouped into four lineages, A to D; the prevalences of lineages A/B/C/D were respectively 5.1%/ 92.3%/0%/2.6% in Japan (n=39), 34.4%/62.5%/0%/3.1% in the Philippines (n=32), and 15.8%/73.7%/7.9%/2.6% in Vietnam (n=38).The distribution patterns of HPV-16 and HPV -52 lineages in these countries differed significantly (p<0.000001 and p=0.0048, respectively). There was no significant relationship between abnormal cervical cytology and either HPV-16 E6/E7 lineages or specific amino acid mutations, such as E6 D25E, E6 L83V, and E7 N29S. Analysis of HPV-16 and HPV-52 E6/E7 genes can be a useful molecular-epidemiological tool to distinguish geographical diffusion routes of these HPV types in Asia.3

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“…11 However, in the subgroup of those who ever traded sex, the prevalence of oral HPV infection doubled, mirroring the high prevalence of genital HPV infection (from 42.5%–85.0%) in this specific group in Vietnam. 25, 26 …”

Section: Discussionmentioning

confidence: 99%

Self-reported oral health, oral hygiene, and oral HPV infection in at-risk women in Ho Chi Minh City, Vietnam

Bui

Trần

Markham

et al. 2015

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Objectives This study aimed to examine the relationship between self-reported oral health, oral hygiene practices, and oral human papillomavirus (HPV) infection among women at risk for sexually transmitted infections in Ho Chi Minh City, Vietnam. Study design Convenience and referral sampling methods were used in a clinic-based setting to recruit 126 women aged 18–45 years between August–October 2013. Behavioral factors were self-reported. Oral-rinse samples were tested for HPV DNA of two low-risk and 13 high-risk genotypes. Results A higher unadjusted prevalence of oral HPV infection was associated with poorer self-rated overall oral health (p=.001), reporting oral lesions/problems in the past year (p=.001), and reporting a tooth loss not because of injury (p=.001). Higher unadjusted prevalence of oral HPV infection was also associated with two measures of oral hygiene: lower frequencies of toothbrush per day (p=.047) and gargling without toothbrush (p=.037). After adjusting for other factors in multivariable logistic regression models, poorer self-rated overall oral health remained statistically associated with oral HPV infection (p=.042); yet, the frequency of toothbrush per day did not (p=.704). Conclusion Results corroborate the association between self-reported poor oral health and oral HPV infection. The effect of oral hygiene on oral HPV infection remains inconclusive.

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Infection with high‐risk HPV types among female sex workers in northern Vietnam

Cited by 19 publications

References 43 publications

Molecular Genotyping of Human Papillomavirus L1 Gene in Low-Risk and High-Risk Populations in Bangkok

Molecular Genotyping of Human Papillomavirus L1 Gene in Low-Risk and High-Risk Populations in Bangkok

E6 and E7 variants of human papillomavirus‐16 and ‐52 in Japan, the Philippines, and Vietnam

Self-reported oral health, oral hygiene, and oral HPV infection in at-risk women in Ho Chi Minh City, Vietnam

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