Infection with GB virus C (GBV‐C) in patients with chronic liver disease or on maintenance hemodialysis in Indonesia

Tsuda, Fumio; Hadiwandowo, Soeliadi; Sawada, Natsumi; Fukuda, M; Tanaka, Takeshi; Okamoto, Hiroaki; Miyakawa, Yuzo; Mayumi, Makoto

doi:10.1002/(sici)1096-9071(199607)49:3<248::aid-jmv15>3.3.co;2-q

Cited by 21 publications

(26 citation statements)

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“…The transmission of HPgV is parenteral, and is highly prevalent in patients exposed to transfused blood (and its components), and in intravenous drug users [Gutierrez et al, ; Shrestha et al, ; Liu et al, ; Desai et al, ]. Hemodialysis patients, patients that have undergone organ transplantation, as well as post‐transfusion hepatitis patients, carry a high load of the virus [Masuko et al, ; Tsuda et al, ; Sugai et al, ; Ross et al, ; Komatsu et al, ; Hitzler and Runkel, ]. Furthermore, the virus can be sexually transmitted [Tanaka et al, ; Ibanez et al, ; Hattori et al, ], as well as vertically from mother to child, and intra‐familially [Viazov et al, ; Zanetti et al, ; Ohto et al, ].…”

Section: Introductionmentioning

confidence: 99%

Detection and phylogenetic analysis of human pegivirus (GBV-C) among blood donors and patients infected with hepatitis B virus (HBV) in Qatar

et al. 2015

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Human Pegivirus (HPgV), formerly GB virus-C/Hepatitis G virus (GBV-C/HGV), collectively known as GBV-C, is widely spread and has been reported to be associated with non-A-E hepatitis. To our knowledge, no previous study was conducted about HPgV in Qatar. Thus, the objectives of this study were as follows: (i) to determine the rates of HPgV infection in Qatar among healthy blood donors and HBV-infected patients, and (ii) to determine the most predominant HPgV genotype in Qatar. A total of 714 blood plasma samples from healthy donors (612) and HBV-infected patients (102) were collected. RNA was extracted, reversed transcribed, and then subjected for HPgV detection by two round-nested PCR using primers amplifying a 208 bp of 5'-UTR of the HPgV. For genotyping, the 5'-UTR PCR products (from 25 randomly picked samples) were cloned and sequenced. The overall infection rate of HPgV in Qatar was 13.3%. There was no significant difference (P = 0.41) in the infection rates between healthy donor (13.7%) and in HBV-infected patients (10.7%). Moreover, we did not find any significant association between HPgV infection rates and nationality, sex, or age (P > 0.05). Sequence analysis of 40 5'-UTR PCR amplicons yielded the European genotype 2 as most predominant in Qatar, although other genotypes (5 and 7) were also present. Our results indicate that there is no strong correlation between HPgV infection rate, condition, nationality, age, and sex, and genotype 2 is most predominant in Qatar.

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Section: Introductionmentioning

confidence: 99%

Detection and phylogenetic analysis of human pegivirus (GBV-C) among blood donors and patients infected with hepatitis B virus (HBV) in Qatar

et al. 2015

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“…Therefore, transfusion was the main source of GBV-C infection in the patients on maintenance hemodialysis in Nepal. Aside from transfusions, nosocomial transmission of GBV-C can occur through shared dialysis equipment among hemodialysis patients, which can be verified by sequence analysis of GBV-C isolates infecting them [Masuko et al, 1996;Tsuda et al, 1996;Wang et al, 1997].…”

Section: Discussionmentioning

confidence: 99%

“…Although the disease-inducing activity of GBV-C is not clear as yet, the viral RNA is detected more frequently in patients with acute or chronic non-A to E hepatitis than in controls Fiordalisi et al, 1996]. GBV-C frequently co-infects with hepatitis viruses such as hepatitis C virus (HCV) and hepatitis B virus (HBV) [Simons et al, 1995;Linnen et al, 1996;Masuko et al, 1996;Tsuda et al, 1996]. It transmits parenterally typified by transfusions and illicit intravenous drugs [Aikawa et al, 1996;Masuko et al, 1996;Wang et al, 1996;Alter et al, 1997].…”

Section: Introductionmentioning

confidence: 99%

Infection with GB virus C and hepatitis C virus in drug addicts, patients on maintenance hemodialysis, or with chronic liver disease in Nepal

Shrestha¹,

Tsuda²,

Sawada³

et al. 1997

J. Med. Virol.

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Infection with GB virus C (GBV-C) and hepatitis C virus (HCV) was surveyed in various populations in Kathmandu, Nepal. GBV-C RNA and HCV RNA were detected in four (2%) and none, respectively, of 181 normal controls. Viral RNAs were detected significantly more frequently (P < 0.001) in 32 (44%) and 43 (60%), respectively, of 72 users of illicit intravenous drug, and in three (14%) and one (5%) of 22 patients on maintenance hemodialysis. The three hemodialysis patients with GBV-C RNA had been transfused with more blood units than the 19 without GBV-C RNA (51 +/- 21 vs. 5 +/- 3 units, P < 0.01), and one was co-infected with HCV. Of 145 patients with chronic liver disease, GBV-C RNA was detected in four (3%) and HCV RNA in 12 (8%); only one patient with GBV-C RNA was without markers of HCV or hepatitis B virus infection. In the 32 drug addicts infected with GBV-C, genotypes were G1 in two (6%), G2 in 26 (81%), G3 in three (9%), and the remaining one (3%) was coinfected with G2 and G3. GBV-C genotypes in the 13 individuals in the populations other than drug addicts were G2 in 11 (85%) and G3 in two (15%). HCV genotypes in the 43 drug addicts with viremia were l/1a in 21 (49%), V/3a in 19 (44%) and l/1a plus V/3a in two (5%); these genotypes were not prevalent in normal controls and patients with chronic liver disease in Nepal. These results indicate that GBV-C infection is prevalent in healthy subjects in Nepal at a frequency (2%) comparable with those in the other countries and that GBV-C transmits efficiently by intravenous drug abuse among drug addicts and by transfusion in hemodialysis patients.

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“…An epidemiologic study demonstrated that among new cases of non-A, non-B hepatitis in the United States, 80% were due to HCV infection and the other 20% were due to HGV infection. 271 It is known that HGV follows the patterns of blood-borne transmission and that HGV viremia can persist for years. 263 The prevalence of HGV infection in hemodialysis patients has been reported to be variable among countries and in different regions within a country.…”

Section: Hepatitis Gmentioning

confidence: 99%

Complications Associated with Hemodialysis

Wali

Kaluvapalle

Cheung³

2008

Therapy in Nephrology &Amp; Hypertension

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Infection with GB virus C (GBV‐C) in patients with chronic liver disease or on maintenance hemodialysis in Indonesia

Cited by 21 publications

References 0 publications

Detection and phylogenetic analysis of human pegivirus (GBV-C) among blood donors and patients infected with hepatitis B virus (HBV) in Qatar

Detection and phylogenetic analysis of human pegivirus (GBV-C) among blood donors and patients infected with hepatitis B virus (HBV) in Qatar

Infection with GB virus C and hepatitis C virus in drug addicts, patients on maintenance hemodialysis, or with chronic liver disease in Nepal

Complications Associated with Hemodialysis

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