Infection with cytomegalovirus in homosexual men.

Coutinho, Roel A.; Dillen, Pauline Wertheim-van; Lent, P Albrecht-van; Nagelkerke, Nico; Kuipers, Hester; Haagen, A van Bentum-van; Rijsdijk, T; Noordaa, J. van der

doi:10.1136/sti.60.4.249

Cited by 11 publications

(3 citation statements)

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“…1 In the MSM population, the number of partners, history of other sexually transmitted infections, anal contact, and lifetime duration of sexual activity all correlate with the risk of CMV acquisition over time. 2 Although CMV IgM may be nonspecifically elevated during reactivation, this patient's significantly elevated CMV IgM level in the context of a new sexual contact, an appropriate latency period, violent gastrointestinal symptoms, prominent involvement of the rectum, rash, markedly elevated CMV viral load, atypical lymphocytosis, and abnormal liver function tests strongly supported a diagnosis of primary CMV infection acquired via unprotected receptive anal intercourse. CMV IgG was not obtained, given the duration of symptoms at presentation.…”

Section: Discussionmentioning

confidence: 68%

First report of sexually transmitted primary cytomegalovirus proctocolitis in a renal transplant recipient

Hogan

Steiner

Sifri

2021

Transplant Infectious Dis

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Section: Discussionmentioning

confidence: 68%

First report of sexually transmitted primary cytomegalovirus proctocolitis in a renal transplant recipient

Hogan

Steiner

Sifri

2021

Transplant Infectious Dis

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“…There is a vast diVerence between the frequency of seropositivity in the gay male compared with hetereosexual males of the same socio-economic stratum (94 vs 54%, [27]). CMV seropositivity or latent infection was correlated with duration of sexual activity, number of sexual partners, history of syphilis and anal intercourse [28,29]. Interestingly, there is also evidence of continuous lytic infection activity in the immunocompetent healthy sexually active gay male.…”

Section: Scope Of Cytomegalovirus Infection and Diseasementioning

confidence: 79%

The history of cytomegalovirus and its diseases

2007

Med Microbiol Immunol

175

133

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Intranuclear inclusions typical of cytomegalovirus infections were Wrst noticed in 1881 by German scientists who thought they represented protozoa. After viruses were grown in cell cultures, Weller, Smith and Rowe independently isolated and grew CMV from man and mice in [1956][1957]. Antibodies in 30-100% of normal adults indicate not only a past infection, but the presence of a present latent infection. The presence of CMV DNA in tissues and most organs surveyed indicates the ubiquity of latent infection. CMV disease requires the virus and some deWciency of immunity such as occurs in the immature fetus, in AIDS, and in transplant patients on immunosuppressive drugs. Antiviral agents can inhibit CMV replication but they cannot prevent or cure latent infections. A pharmacological approach using the many leads in understanding latency is needed. Keywords Antiviral therapy · CMV in AIDS · CMV after transplantation · Discovery of CMV · Epidemiology of CMV · Latent infection by CMV Discovery of cytomegalovirusRibbert [1] wrote that in 1881, he saw large cells in sections of the kidney of a luetic stillborn and in the parotid gland of children which he was unable to interpret until he saw the report of Jesionek and Kiolemenoglou ( Von Glahn and Pappenheimer [4] noted that Lipschuetz [5] had discovered intranuclear inclusion containing cells in lesions in man infected by herpes zoster and herpes genitalis. Thus they believed such abnormal cells were produced by viruses, and they doubted that they were related to protozoa. This was the Wrst indication that cells with intranuclear inclusions might be related to a group of related viruses, now known as the herpesviridae.Farber and Wolbach [6] found such inclusion bearing cells in the salivary glands of 26 out of 183 children examined after death from diverse causes. This was the Wrst approximation of the fact that infection by cytomegalovirus is highly frequent.By 1932, 25 cases of a rare lethal congenial infection characterized by petechiae, hepatosplenomegaly, and intracerebral calciWcation had been described. All of them had cells with typical intranuclear inclusions. Wyatt et al. [7] suggested the name, "generalized cytomegalic inclusion disease (CID)", although its viral etiology was not yet known. A uniform site of involvement were cells of the renal tubules. They suggested that the disease might be diagnosed during life by searching for cells with inclusions in urinary sediments.Following this clue, Fetterman [8] made a cytological preparation from the urine sediment of a suspected case, and made the Wrst intravitum diagnosis of CID.Minder [9] Wrst saw by electronmicroscopy 199 nm particles, suggestive of a virus, in the clear halo around the intranuclear inclusion of pancreatic cells in a case of CID.

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“…Mintz et al (1983) found that of seven different practices of the men, only passive analgenital intercourse correlated significantly with the acquisition of CMV infection. Coutinho et al (1984) and Collier et al (1987) found that seropositivity correlated with duration of sexual activity, nurober of sex partners, history of syphilis, and anal intercourse. The acquisition of primary CMV infection was only correlated with a history of syphilis and anal intercourse.…”

Section: Homosexual Transmissionmentioning

confidence: 99%

Cytomegalovirus

1991

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All rights reserved 90-14345 CIP No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher Preface to the First EditionAlthough there are a number of excellent current reviews on one or another aspect of cytomegalovirus, the last comprehensive treatment of this subject was that of Krech et al. (197la). In view of the amazing advances in the virological, epidemiologic, and clinical knowledge of cytomegaloviruses, an up-to-date book is needed. Such a work should cover many areas of expertise and a voluminous technical literature. Each area might have been reviewed and analyzed by workers more expert than myself. However, I have embarked on the entire venture alone in order to attain unity and continuity in this book, characteristics that are not easily achieved in the more popular multiauthored works. I have tried to review the Iiterature and provide a critical summary for each area discussed. To do this, I provide as much of the primary data of the relevant works as needed and not just the qualitative conclusions. Inevitably, the flow of the narrative may be interrupted by dry facts and figures. However, such information is essential to make this a meaningful reference work. But for those not interested in such details, I have provided at what I hope are crucial points critiques and summaries.This book is not an exhaustive review of all the literature. This is probably no Ionger possible or even desirable. By selection, however, one runs the risk of having missed or ignored important papers. I am keenly aware of this, and I wish to apologize for such oversight, if that is possible.I visualize this work as being useful for physicians, scientists, and students interested in the biology of and infection by human cytomegalovirus. I feel that to understand these, the basic virology of this virus and related herpesviruses must be included. Topics that have not advanced a great deal and that are adequately described in available works, such as the anatomic pathology, have not been reviewed in detail. The emphasis has been placed on newer insights in the virology, immunology, serology, epidemiology, and especially clinical aspects of human cytomegalovirus. I wish tobring out the interactions of knowledge in these areas. Part II is a much shorter treatment of the nonhuman cytomegaloviruses, reviewed primarily from the point of view of their contribution to the understanding of the human virus. V vi Preface to the First Edition Finally, I wish to thank Drs. Charles R. Rinaldo, Jr., John A. Armstrong, and Donald N. Medearis for their critical review of the manuscript. Their suggestions were invaluable. Dr. John N. Dowling's thorough review of CMV infection in patients with malignancies was the basis of Section 13.4. I also acknowledge the indispensable and patient secretarial assistance of Ms.The remarkable medical events and advances in knowle...

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Infection with cytomegalovirus in homosexual men.

Cited by 11 publications

References 14 publications

First report of sexually transmitted primary cytomegalovirus proctocolitis in a renal transplant recipient

First report of sexually transmitted primary cytomegalovirus proctocolitis in a renal transplant recipient

The history of cytomegalovirus and its diseases

Cytomegalovirus

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