Infection versus immunity: What's the balance?

Shearer, William T.

doi:10.1016/j.jaci.2005.06.001

Cited by 4 publications

(4 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most PIDs are inherited as monogenic disorders, and once the clinical and immunological phenotype is established in a given patient, existing technolo-gies, such as using targeted gene sequencing, allow for the identification of the underlying genetic defect in the proband (that is, the affected individual) and in family members. [53][54][55][56][57][58][59] Genetic characterization of PIDs in humans is crucial for providing better care of patients and families-for example, definitive diagnosis, counseling, family screening, and prenatal and early neonatal diagnosis. [60][61][62][63][64][65][66][67] Identification of the underlying genetic defect may also have implications for treatment because gene therapy (for example, gene-modified autologous stem-cell transplantation) has recently emerged as a possible option for patients with severe combined immunodeficiency who have no available HLA-matched donor for allogeneic stem-cell transplantation.…”

Section: Implications Of Genetic Diagnosticsmentioning

confidence: 99%

“…Most PIDs are inherited as monogenic disorders, and once the clinical and immunological phenotype is established in a given patient, existing technologies, such as using targeted gene sequencing, allow for the identification of the underlying genetic defect in the proband (that is, the affected individual) and in family members 53–59 . Genetic characterization of PIDs in humans is crucial for providing better care of patients and families—for example, definitive diagnosis, counseling, family screening, and prenatal and early neonatal diagnosis 60–67 .…”

Section: Implications Of Genetic Diagnosticsmentioning

confidence: 99%

“…51,52 Finally, considering that no one has recovered from infection by human immunodeficiency virus or rabies virus (without postexposure prophylaxis), and that none of us are immune to the yearly emerging influenza viruses, it is clear that the term immunocompetence is somewhat questionable-or at least it is context dependent. 2,9,53,54 For the term implies that we are all originally-and in various ways-immunodeficient, that is, genetically predisposed to infections to various degrees. Thus, understanding the variety and nature of PIDs means understanding basic and clinical genetics of infectious diseases.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The creation and progress of the J Project in Eastern and Central Europe

Maródi

2011

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

Primary immunodeficiencies (PIDs) have now become recognized as a worldwide health problem. Rapid development of immunological and genetic technologies has led to the discovery of more than 200 PIDs and more than 150 disease-related genes. Progress in the field is expected to take a new turn after the introduction of new-generation sequencing technologies that will enable searches for currently unknown PID-related genes. By contrast, even with progress in molecular genetics, many patients remain ill and die early because of the lack of diagnostic or treatment facilities, or both. Thus, the gap between the knowledge accumulated and the appropriate management of patients with PIDs in everyday clinical practice has widened, necessitating PID awareness, particularly in countries with poor socioeconomic conditions. The J Project, established as a physician education and research collaboration program in Eastern and Central Europe, demonstrates how professional responsibility and long-term joint efforts can make a beneficial difference for patients with inborn errors of immunity.

show abstract

Section: Implications Of Genetic Diagnosticsmentioning

confidence: 99%

Section: Implications Of Genetic Diagnosticsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The creation and progress of the J Project in Eastern and Central Europe

Maródi

2011

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

show abstract

“…Humans have made various efforts to maintain and improve health and immunity, such as consuming various vitamins that can increase endurance and, at certain times, basking in the sun. According to [1], immunity is an important factor for survival and preventing diseases caused by infections, including Covid-19 infection. Immunity is especially important for children since the process of bone formation and increasing endurance needs vitamin D. When the skin is exposed to sunlight containing ultraviolet (UV) rays, this process will trigger the synthesis of vitamin D in the body.…”

Section: Introductionmentioning

confidence: 99%

Dynamic Neural Network Model Design for Solar Radiation Forecast

Bahri

Alfian²,

Fitriyani³

2022

LKJITI

View full text Add to dashboard Cite

Sunlight is an energy source that is a gift from God and is a source of life for living things, including humans as caliphs on earth. Judging from its impact, solar radiation is an environmental parameter that has positive and negative effects on human life. The pattern of distribution of solar radiation is important information for human life to be the attention of many people, both policymakers and researchers in the field of environment. This study objects to modeling the radiation of solar using a dynamic neural network (DNN) model. The data used in this research is the meteorological data of Mataram City for the period January 2018 to May 2019, which was obtained from the Department of Environment and Forestry of West Nusa Tenggara Province. In the development of this model, solar radiation was seen as a function of a combination of several variables related to meteorological (wind speed, wind direction, humidity, air pressure, and air temperature) and solar radiation data at some previous time. Considering the advantages and effectiveness of the activation function in the proposed DNN model learning process, this study's network learning in the hidden layer employed two activation functions: hyperbolic tangent (Type I) and hyperbolic tangent sigmoid functions (Type II). The output aggregation used two aggregates for each type: the weighted aggregation function (Type a) and the maximum function (Type b). The results of computer simulations based on the root of mean square error (RMSE) measure indicate that the model for modeling solar radiation in these two cases is quite accurate. Furthermore, it could be seen that the model's performance using the hyperbolic tangent activation function (Type b) is relatively better than the hyperbolic tangent sigmoid type of the activation function (Type a), with the RMSE values are 18.3924 and 18.4005, respectively.

show abstract

Immunodeficiency due to congenital, metabolic, infectious, surgical and environmental factors

Chinen¹,

Shearer²

2008

Clinical Immunology

View full text Add to dashboard Cite

Infection versus immunity: What's the balance?

Cited by 4 publications

References 41 publications

The creation and progress of the J Project in Eastern and Central Europe

The creation and progress of the J Project in Eastern and Central Europe

Dynamic Neural Network Model Design for Solar Radiation Forecast

Immunodeficiency due to congenital, metabolic, infectious, surgical and environmental factors

Contact Info

Product

Resources

About