Infection Route of Parvimonas micra: A Case Report and Systematic Review

Shimizu, K; Horinishi, Yuta; Sano, Chiaki; Ohta, Ryuichi

doi:10.3390/healthcare10091727

Cited by 13 publications

(18 citation statements)

References 57 publications

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“…Parvimonas micra , which is part of the normal flora of the oral cavity and the mucosa of the gastrointestinal tract, skin, and female genital tract, 5 was previously considered an oral pathogen primarily (as P. micra is commonly a causative pathogen of chronic periodontitis). 6 Recent studies have shown that the most common site of extraoral P. micra infection is the spine, 7 followed by the joints, 8 and heart valves. 9 Moreover, P. micra has been shown to cause bacteraemia, 10 meningitis, 11 cervical and brain abscesses, 12 liver abscesses, 13 and iliopsoas abscesses.…”

Section: Discussionmentioning

confidence: 99%

Severe pneumonia with empyema caused by Parvimonas micra and Streptococcus constellatus co-infection: a case report

Duan,

Feng,

Shen

et al. 2023

J Int Med Res

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Empyema is a common complication of pneumonia, caused by the accumulation of purulent exudate due to pathogenic bacteria invading the pleural cavity. Parvimonas micra and Streptococcus constellatus are pathogens that rarely cause pneumonia with empyema. Herein, a case of severe empyema caused by these two pathogens, confirmed by metagenomic next-generation sequencing (mNGS) of pleural effusion cultures, is reported. A male Chinese patient in his late sixties presented with wheezing, cough, sputum expectoration, and fever. Blood and sputum cultures were negative for pathogens, but the pleural effusion culture was positive for S. constellatus, and was also found to contain P. micra, confirmed by mNGS. The patient’s symptoms improved after treatment with cefoperazone/sulbactam and moxifloxacin. Pneumonia caused by P. micra and S. constellatus is rare; however, coinfection with these pathogens may cause severe pneumonia, with or without empyema.

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Section: Discussionmentioning

confidence: 99%

Severe pneumonia with empyema caused by Parvimonas micra and Streptococcus constellatus co-infection: a case report

Duan,

Feng,

Shen

et al. 2023

J Int Med Res

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“…Participants were patients at Unnan City Hospital, Japan, over 18 years of age, presenting with local and systemic infectious symptoms, and a positive blood culture for Gram-negative rods. Exclusions were patients without infection symptoms, those with upper respiratory or skin infections, and those without a blood culture [ 12 , 13 ]. This study focused on bloodstream infections originating from urinary, gastrointestinal, and hepatobiliary tracts or bacterial translocation.…”

Section: Methodsmentioning

confidence: 99%

“…Bacterial translocation was identified as Gram-negative rod detection in blood culture without organ-specific symptoms [ 9 ]. Risk factors were based on previous studies, with data extracted from electronic records [ 12 , 13 ]. Covariates included age, sex, BMI, care dependency, and comorbidities.…”

Section: Methodsmentioning

confidence: 99%

Bacterial Translocation As the Origin of Gram-Negative Rods Bloodstream Infection Among Older Patients in Rural Hospitals: A Cross-Sectional Study

Ohta,

Sano

2023

Cureus

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Introduction Bloodstream infections caused by Gram-negative rods are a pressing concern for the aging global population, particularly in rural settings. This study investigates the prevalence and entry pathways of Gram-negative rod bloodstream infections in elderly patients at a rural Japanese hospital, aiming to clarify the frequency and associated factors of straightforward entry and bacterial translocation. Method In this cross-sectional study, we analyzed electronic medical records of patients over 18 years of age with symptomatic Gram-negative rod bloodstream infections at Unnan City Hospital, Japan, from September 2021 to August 2023. We used multivariate logistic regression to assess factors of age, sex, body mass index, care dependency, and comorbidities. Results Among the participants who met the inclusion criteria, significant differences were observed in age, sex, inpatient status, and prevalence of conditions like respiratory diseases and cancer between the straightforward entry and bacterial translocation groups. Escherichia coli was the most common pathogen identified. Conclusion The study emphasizes the need for tailored medical approaches for elderly patients with bloodstream infections, considering their unique health profiles and risks. It highlights the importance of age, inpatient status, and cancer in determining infection risks, pointing to areas for further research to enhance infection management and healthcare outcomes in older populations.

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“…Parvimonas micra is implicated as the causative agent in a spectrum of ailments, ranging from sternum osteomyelitis ( 3 ), and femur osteomyelitis ( 4 ), to sepsis ( 5 ), endocarditis ( 5 ), hepatic abscesses ( 6 , 7 ), and even fatal outcomes ( 1 ). Notably, P. micra predominantly affects immunocompromised hosts ( 8 , 9 ) with infected individuals often presenting underlying risk factors such as oral infections, diabetes mellitus, and malignant tumors ( 9 , 10 ). Manifestations of P. micra infections typically lack specificity, with reported symptoms encompassing fever, chills, low back pain, abdominal discomfort, gastrointestinal issues, body aches, impaired consciousness, and anorexia in 46 percent of cases ( 6 , 10 ), as per reviews.…”

Section: Introductionmentioning

confidence: 99%

“…Notably, P. micra predominantly affects immunocompromised hosts ( 8 , 9 ) with infected individuals often presenting underlying risk factors such as oral infections, diabetes mellitus, and malignant tumors ( 9 , 10 ). Manifestations of P. micra infections typically lack specificity, with reported symptoms encompassing fever, chills, low back pain, abdominal discomfort, gastrointestinal issues, body aches, impaired consciousness, and anorexia in 46 percent of cases ( 6 , 10 ), as per reviews.…”

Section: Introductionmentioning

confidence: 99%

Hemoptysis caused by Parvimonas micra: case report and literature review

Shao,

He,

Jiao

et al. 2024

Front. Public Health

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BackgroundParvimonas micra (P. micra), a Gram-positive anaerobic bacterium, exhibits colonization tendencies on oral mucosal and skin surfaces, potentially evolving into a pathogenic entity associated with diverse diseases. The diagnostic trajectory for P. micra-related diseases encounters delays, often with severe consequences, including fatality, attributed to the absence of symptom specificity and challenges in culture. The absence of a consensus on the diagnostic and therapeutic approaches to P. micra exacerbates the complexity of addressing associated conditions. This study aims to elucidate and scrutinize the clinical manifestations linked to P. micra, drawing insights from an extensive literature review of pertinent case reports.Case presentationA 53-year-old male sought medical attention at our institution presenting with recurrent hemoptysis. Empirical treatment was initiated while awaiting pathogen culture results; however, the patient’s symptoms persisted. Subsequent metagenomic next-generation sequencing (mNGS) analysis revealed a pulmonary infection attributable to P. micra. Resolution of symptoms occurred following treatment with piperacillin sulbactam sodium and moxifloxacin hydrochloride. A comprehensive literature review, utilizing the PubMed database, was conducted to assess case reports over the last decade where P. micra was identified as the causative agent.ConclusionThe literature analysis underscores the predilection of P. micra for immunocompromised populations afflicted by cardiovascular diseases, diabetes, orthopedic conditions, and tumors. Risk factors, including oral and periodontal hygiene, smoking, and alcohol consumption, were found to be associated with P. micra infections. Clinical manifestations encompassed fever, cough, sputum production, and back pain, potentially leading to severe outcomes such as Spondylodiscitis, septic arthritis, lung abscess, bacteremia, sepsis, and mortality. While conventional bacterial culture remains the primary diagnostic tool, emerging technologies like mNGS offer alternative considerations. In terms of treatment modalities, β-lactam antibiotics and nitroimidazoles predominated, exhibiting recovery rates of 56.10% (46/82) and 23.17% (19/82), respectively. This case report and literature review collectively aim to enhance awareness among clinicians and laboratory medicine professionals regarding the intricacies of P. micra-associated infections.

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Infection Route of Parvimonas micra: A Case Report and Systematic Review

Cited by 13 publications

References 57 publications

Severe pneumonia with empyema caused by Parvimonas micra and Streptococcus constellatus co-infection: a case report

Severe pneumonia with empyema caused by Parvimonas micra and Streptococcus constellatus co-infection: a case report

Bacterial Translocation As the Origin of Gram-Negative Rods Bloodstream Infection Among Older Patients in Rural Hospitals: A Cross-Sectional Study

Hemoptysis caused by Parvimonas micra: case report and literature review

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