Infection-responsive long-term antibacterial bone plates for open fracture therapy

Zhang, Lujiao; Yang, Yunxia; Xiong, Yan‐Hua; Zhao, Yuqing; Xiu, Zongpeng; Ren, Hui-Min; Zhang, Kai; Duan, Shun; Chen, Ying; Xu, Fu-Jian

doi:10.1016/j.bioactmat.2023.01.002

Cited by 13 publications

(6 citation statements)

References 67 publications

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“…We found that composite wall materials (gelatin, maltodextrin, sodium glutamate, skim milk and polyvinylpyrrolidone) had an excellent protective effect on LR-LFCA. Gelatin shows excellent film-forming ability [31]. Skim milk proteins and maltodextrin protect bacteria from the damage caused by harsh environments [32,33].…”

Section: Discussionmentioning

confidence: 99%

Microencapsulated Limosilactobacillus reuteri Encoding Lactoferricin-Lactoferrampin Targeted Intestine against Salmonella typhimurium Infection

Wang,

Xie,

Cai

et al. 2023

Nutrients

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Salmonella enterica serovar Typhimurium (S. typhimurium) is an important foodborne pathogen that infects both humans and animals and develops acute gastroenteritis. As porcine intestines are relatively similar to the human ones due to their relatively similar sizes and structural similarity, S. typhimurium causes analogous symptoms in both. Novel strategies for controlling S. typhimurium infection are also desired, such as mucosal-targeted delivery of probiotics and antimicrobial peptides. The bovine lactoferricin-lactoferrampin-encoding Limosilactobacillus reuteri (LR-LFCA) strain improves intestinal barrier function by strengthening the intestinal barrier. Weaned piglets were selected for oral administration of microencapsulated LR-LFCA (microcapsules entrap LR-LFCA into gastro-resistant polymers) and then infected with S. typhimurium for 3 days. We found that orally administering microencapsulated LR-LFCA to weaned piglets attenuated S. typhimurium-induced production of inflammatory factors in the intestinal mucosa by inhibiting the nuclear factor-kappa B (NF-κB) and P38 mitogen-activated protein kinases (MAPK) signaling pathway. Moreover, microencapsulated LR-LFCA administration significantly suppressed the oxidative stress that may correlate with gut microbiota (reduced Salmonella population and increased α-diversity and Lactobacillus abundance) and intestinal function (membrane transport and metabolism). Our work demonstrated that microencapsulated LR-LFCA effectively targeted intestine delivery of Lactobacillus and antimicrobial peptides and modulated gut microbiota and mucosal immunity. This study reveals a novel targeting mucosal strategy against S. typhimurium infection.

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Section: Discussionmentioning

confidence: 99%

Microencapsulated Limosilactobacillus reuteri Encoding Lactoferricin-Lactoferrampin Targeted Intestine against Salmonella typhimurium Infection

Wang,

Xie,

Cai

et al. 2023

Nutrients

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“…The released Gent concentration in our study fell within the range of effective antibacterial concentration as reported previously. In the work by Zhang et al [39], Gent was covalently grafted into the sodium alginate layer on the Ti implant surface, which also reached a concentration of approximately 87 µg/mL within 4 h. The coated Ti implant exhibited an in vitro and in vivo anti-infection ability. Nishtha Gaur et al [40] utilized cold atmospheric plasma (CAP) to trigger the release of Gent from sodium polyacrylate particles in a hydrogel matrix.…”

Section: Drug Release Behavior Of Hap/zif-8@gent Coatingsmentioning

confidence: 99%

Surface Modification of Hydroxyapatite Coating for Enhanced Antibiotic Therapy

Jia,

Li,

et al. 2024

Coatings

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A major strategy to combat implant-associated infections is to develop implant coatings with intrinsic antibacterial activity. Since hydroxyapatite (HAp) coatings and antibiotic administration are commonly used in clinical settings, developing HAp-coated implants with localized antibiotic-releasing properties has attracted popularity. Considering the antibacterial metal species (Ag, Zn, Cu, etc.) in metal–organic frameworks and their drug delivery capacity, in this study, a gentamicin-loaded zeolitic imidazolate framework-8 nanolayer was deposited on a plasma-sprayed HAp coating (HAp/ZIF-8@Gent), which served as a Gent and Zn2+ reservoir. The investigation on the binding interaction between ZIF-8 and HAp indicated that the growth of ZIF-8 was through a Zn2+ seed layer on the HAp coating via an adsorption–replacement mechanism, instead of simple physical adsorption. The HAp/ZIF-8@Gent coating exhibited a sustained drug-release property, and the cumulative concentration of released Gent reached 239.8 ± 7.1 μg/mL on day 8. Compared to the HAp-Zn and HAp/ZIF-8 coatings, the HAp/ZIF-8@Gent coating exhibited significantly higher antibacterial activity against E. coli. This was ascribed to the combined antibacterial effects of Zn2+ and Gent. The cytocompatibility of the HAp/ZIF-8@Gent coating was confirmed via cell proliferation. Above all, the ZIF-8-modified HAp coating with localized delivery of Gent and Zn2+ possessed excellent antibacterial activity and acceptable cytocompatibility, showing potential in mitigating implant-associated infections.

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“…Proses penyembuhan patah tulang bisa dilakukan dengan proses remodelling namun hanya 50% dapat diterima oleh tulang alveolar dan proses penyembuhan berlangsung selama tiga bulan (Kovac et al, 2023). Dalam proses penyembuhan tantangan utama adalah infeksi setelah fiksasi patah tulang yang dapat menyebabkan komplikasi, penyembuhan yang lama, kehilangan tulang secara permanen, amputasi bahkan kematian (Zhang et al, 2023). Oleh karena itu proses penyembuhan patah tulang membutuhkan alat bantu berupa bone plate yang mampu secara signifikan menahan tegangan tekan di bagian permukaan.…”

Section: Pendahuluanunclassified

Pemodelan Tegangan dan Regangan pada Bone Plate dengan Menggunakan Material Stainless Steel 316 L

Fikri

2023

ijmst

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Jumlah populasi dan kualitas hidup manusia terus bertambah sehingga membutuhkan teknologi yang lebih maju dalam menyelesaikan masalah hidupnya. Semakin banyaknya populasi manusia maka jumlah kendaraan dan pekerjaan konstruksi semakin banyak. Hal ini menjadikan kecelakaan kerja berupa patah tulang sering terjadi di masyarakat. Patah tulang merupakan penyakit traumatik yang umum terjadi pada manusia. Proses penyembuhan patah tulang bisa dilakukan dengan fiksasi yang tergantung pada stabilitas dan proses biologi pada tulang yang patah. Proses fiksasi membutuhkan alat bantu berupa bone plate. Sedangkan proses biologis membutuhkan material yang biokompatibel sebagai alat bantu fiksasi tulang. Stainless steel 316L Menunjukkan kemampuan biokompatibel dan biomekanik yang baik untuk digunakan sebagai penyangga patah tulang. Sebelum dilakukan pemasangan bone plate stainless steel 316L pada pasien perlu dilakukan pemodelan untuk mengetahui perilaku material tersebut saat diberi beban. Pemodelan dilakukan dengan menggunakan CAD/CAM. Bonplate dibuat dengan mengikuti dimensi bone plate pada umumnya kemudian diberi beban. Beban yang diberikan pada bone plate stainless steel 316L berupa gaya tekan yang searah dengan cross sectional sebesar 49 N sampai 492 N. Gaya tersebut merupakan gaya yang umum diterima oleh orang dewasa. Pengaruh gaya tekan berupa tegangan regangan dan perubahan bentuk kemudian dibandingkan dengan kekuatan luluh dan tarik pada material stainless steel 316l. Selain itu pengaruh gaya tekan juga menunjukkan distribusi gaya dan perilaku material saat diberikan beban. Terjadi peningkatan tegangan, regangan dan perubahan bentuk pada material saat beban diberikan. Selain itu deformasi elastis terjadi di seluruh permukaan bone plate stainless steel 316L. Perubahan bentuk terjadi di bagian tengah secara signifikan dan menyebar ke bagian samping pada bone plate stainless steel 316L.

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Infection-responsive long-term antibacterial bone plates for open fracture therapy

Cited by 13 publications

References 67 publications

Microencapsulated Limosilactobacillus reuteri Encoding Lactoferricin-Lactoferrampin Targeted Intestine against Salmonella typhimurium Infection

Microencapsulated Limosilactobacillus reuteri Encoding Lactoferricin-Lactoferrampin Targeted Intestine against Salmonella typhimurium Infection

Surface Modification of Hydroxyapatite Coating for Enhanced Antibiotic Therapy

Pemodelan Tegangan dan Regangan pada Bone Plate dengan Menggunakan Material Stainless Steel 316 L

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