Infection patterns in chronic and aggressive periodontitis

Picolos, Doros; Lerche-Sehm, Julia; Abron, Armin; Fine, James Burke; Papapanou, Panos N.

doi:10.1111/j.1600-051x.2005.00828.x

Cited by 37 publications

(39 citation statements)

References 36 publications

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“…High prevalences and levels of investigated species were observed at subgingival samples at baseline. On the subject level, almost all participants were positive for these species at this timepoint (Table 6) agree with studies using the same technique (Picolos et al 2005). In a previous study, investigating 40 subgingival species in 210 sites from 35 untreated chronic periodontitis patients of Greek origin, we reported prevalences of 27.2% and 11.4% for A. actinomycetemcomitans serotypes b and a, respectively (Sakellari et al 2000).…”

Section: Discussionsupporting

confidence: 88%

Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis

Xajigeorgiou¹,

Sakellari²,

Slini

et al. 2006

J Clinic Periodontology

141

245

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Section: Discussionsupporting

confidence: 88%

Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis

Xajigeorgiou¹,

Sakellari²,

Slini

et al. 2006

J Clinic Periodontology

141

245

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“…This finding was supported by Picolos et al . . They investigated 15 bacterial species, including the classical periodontal pathogens.…”

Section: Discussionmentioning

confidence: 99%

Subgingival microbial profiles of Sudanese patients with aggressive periodontitis

Elabdeen

Mustafa

Hastürk³

et al. 2014

J of Periodontal Research

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Background and Objective Aggressive periodontitis (AgP) is prevalent and shows a rapid course in African individuals. Although a strong focus has been placed on Aggregatibacter actinomycetemcomitans, new methods support the existence of a complex subgingival microflora in AgP. The purpose of the present study was to map the subgingival microbiota as well as explore the presence of A. actinomycetemcomitans and the JP2 clone in a group of Sudanese individuals with AgP, using different analytical methods. Material and Methods A study population consisting of 19 patients with AgP was recruited from patients seeking treatment at University of Science and Technology (UST) in Khartoum. Fifteen healthy subjects were included as controls. Plaque samples were analyzed for 272 taxa using human oral microbe identification microarrays and for 26 periodontal taxa using DNA-DNA hybridization checkerboard. Conventional polymerase chain reaction (PCR) was applied for the detection of A. actinomycetemcomitans and the JP2 clone in plaque. Saliva from patients with AgP was analyzed using quantitative PCR (qPCR) for the detection of A. actinomycetemcomitans. Results Eubacterium yurii was detected more frequently in patients with AgP than in controls, and E. nodatum was found in patients with AgP only. A. actinomycetemcomitans was found in plaque samples of two (12%) patients by human oral microbe identification microarrays and in five (29%) patients with AgP by conventional PCR, as well as in six (32%) of the AgP saliva samples by qPCR. The JP2 clone was identified in only one patient. Conclusion The classical periodontal pathogens were not present in high amounts in AgP in the population studied here. Species of Eubacterium, which are not typically associated with AgP, were often detected in individuals with disease. Using laboratory methods with different sensitivities and detection levels allowed identification of variances in microbial communities. The findings reported in this study provide a basis for the further understanding of AgP.

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“…Specifically, we compared full-mouth clinical measures of periodontitis, subgingival microbial burden, serum antibodies to periodontal species, and "infection ratios" (Picolos et al, 2005) via unpaired 2-tailed t tests assuming equal variances or Fisher exact tests in R. More detailed information is provided in the Appendix.…”

Section: Phenotype Analysesmentioning

confidence: 99%

Gingival Tissue Transcriptomes Identify Distinct Periodontitis Phenotypes

Kebschull

Demmer

Grün³

et al. 2014

J Dent Res

104

107

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The currently recognized principal forms of periodontitischronic and aggressive-lack an unequivocal, pathobiologybased foundation. We explored whether gingival tissue transcriptomes can serve as the basis for an alternative classification of periodontitis. We used cross-sectional wholegenome gene expression data from 241 gingival tissue biopsies obtained from sites with periodontal pathology in 120 systemically healthy nonsmokers with periodontitis, with available data on clinical periodontal status, subgingival microbial profiles, and serum IgG antibodies to periodontal microbiota. Adjusted model-based clustering of transcriptomic data using finite mixtures generated two distinct clusters of patients that did not align with the current classification of chronic and aggressive periodontitis. Differential expression profiles primarily related to cell proliferation in cluster 1 and to lymphocyte activation and unfolded protein responses in cluster 2. Patients in the two clusters did not differ with respect to age but presented with distinct phenotypes (statistically significantly different whole-mouth clinical measures of extent/severity, subgingival microbial burden by several species, and selected serum antibody responses). Patients in cluster 2 showed more extensive/severe disease and were more often male. The findings suggest that distinct gene expression signatures in pathologic gingival tissues translate into phenotypic differences and can provide a basis for a novel classification.

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Infection patterns in chronic and aggressive periodontitis

Abstract: A distinction between the two principal categories of the current periodontitis classification cannot be established by the study of infection patterns.

Cited by 37 publications

References 36 publications

Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis

Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis

Subgingival microbial profiles of Sudanese patients with aggressive periodontitis

Gingival Tissue Transcriptomes Identify Distinct Periodontitis Phenotypes

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