Infection par le virus de l’hépatite C chez les patients diabétiques traités au CHU Gabriel Touré et au Centre de lutte contre le diabète de Bamako (Mali)

Diarra, M.; Konaté, A.; Diakité, Y.; Samaké, K.; Coulibaly, H. Sow; Kassambra, Y.; Tounkara, M; Kaya, Aydın; Kalle, A.; Sidibé, A.T.; Dembélé, M.; Traoré, H. A.; Maïga, M. Y.

doi:10.1007/s12157-013-0487-7

Cited by 5 publications

(8 citation statements)

References 13 publications

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“…The seroprevalence of anti-HCV Ab in our study population is high (11%). The results of our study are identical to those found in the world by other authors [4] [10] [11]. This high prevalence among diabetics is explained by the absence of a policy for the prevention and control of viral hepatitis C in Congo.…”

Section: Discussionsupporting

confidence: 90%

“…in Mali reported a molecular prevalence of 92% [4]. This high prevalence of patients with chronic HCV infection may be due to delayed diagnosis and/or lack of early management of the disease.Indeed, before our investigation, no diabetic patient knew his viral status.…”

Section: Discussionmentioning

confidence: 99%

“…It is estimated that there are approximately 387 million cases of diabetes in the world. This number can reach 592 million by 2035 and 185 million the number of patients with viral hepatitis C, 80% of whom are chronic carriers [1] [3] [4]. It is a major cause of morbidity and mortality because it can be complicated by cirrhosis and hepatocellular carcinoma [3] [4].…”

Section: Introductionmentioning

confidence: 99%

“…This number can reach 592 million by 2035 and 185 million the number of patients with viral hepatitis C, 80% of whom are chronic carriers [1] [3] [4]. It is a major cause of morbidity and mortality because it can be complicated by cirrhosis and hepatocellular carcinoma [3] [4]. It is interesting to note that some studies have shown that the prevalence of HCV infection in diabetics is much higher than that of the normal population; others studies have shown that HCV-infected patients tend to develop diabetes, reason attributed to insulin resistance [5].…”

Section: Introductionmentioning

confidence: 99%

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Seroprevalence and Molecular Biodiverisity of Hepatitis C Infection in Congolese Diabetics

Mongo-Onkouo¹,

Ibobi²,

Gassaye³

et al. 2019

OJGas

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It concerned diabetic patients followed in Brazzaville and Pointe-Noire agreeing to the study, after obtaining the opinion of the ethics committee of the research in health science. All samples collected were screened for the presence of anti HCV Ab using a rapid ALERE HCV test and the Monolisa HCV Ag-Ab ultra test for confirmation in Congo. Detection of the viral RNA was done by PCR retrotranscription and genotyping was performed according to the reverse hybridization technique in France. Data analysis was done with EpiInfo 6.0 software (2016); the proportions were compared using the Chi-square test or the Fisher test at the significance level of 5%. Results: Of 447 patients with diabetes mellitus, 49 had HCV positive serology and the sex ratio was 0.63. Seroprevalence of AC anti HCV was 11% (49/447); HCV RNA was detectable in 71.4% (n = 35) patients. The average age of the population was 62 ± 10 years with extremes ranging from 26 to 82 years. The circulating genotypes were 4 (97.1%) and 1 (2.8%). Subtyping was defined in 17.64% (n = 6) of genotype 4 patients; undefined in 82.36% (n = 28) of Genotype 4 patients, and in one of genotype 1 patients. The subtypes identified were subtype 4e (60%), subtype 4e (8.8%), subtype 4a/4c/4d (5.8%), and subtype 4h (2.9%).

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Seroprevalence and Molecular Biodiverisity of Hepatitis C Infection in Congolese Diabetics

Mongo-Onkouo¹,

Ibobi²,

Gassaye³

et al. 2019

OJGas

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“…The prevalence of SAFI in the University Clinic of Hepato-Gastroenterology during the period of this study was 39%. This result is similar to those of Kom Mogto [3] in Benin in 1999 and Diarra [10] in Mali in 2007, which were 33.3% and 35.9% respectively. It is also close to that of Rimola et al [11] in Barcelona which was 46%.…”

Section: Discussionsupporting

confidence: 89%

Spontaneous Infection of Ascites Fluid at the National and University Hospital Hubert Koutoukou Maga in Cotonou: Prevalence and Associated Factors

Kpossou,

Sokpon,

Obekandon

et al. 2024

OJGas

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Background: Spontaneous ascites fluid infection (SAFI) is an extremely serious and frequently encountered complication in cirrhotic patients. We aimed to determine the prevalence of SAFI and the factors associated with it in the largest hospital in Cotonou. Methods: This was a retrospective descriptive and analytical study conducted from January 2013 to July 2019, at the National and University Hospital Hubert Koutoukou Maga (CNHU-HKM) in Cotonou, Benin. All patients followed in the University Clinic of Hepato-Gastroenterology and diagnosed with SAFI were included. Results: Eighty-two patients were included, predominantly males (69.5%), with a mean age of 51.5 ± 14.5 years. Among them, 32 had SAFI, i.e., a prevalence of 39%. Of the 32 cases of SAFI, the culture of ascites fluid was positive in 6 cases (18.7%). The most frequent germ found in SAFI was Escherichia coli (5 patients, 83.3%). The factors associated with SAFI in this study were: abdominal pain (p = 0.004), increased bilirubinemia (p = 0.009), decreased prothrombin level <50% (p = 0.007), cloudy macroscopic appearance of the fluid (p < 0.001), ascites protide level <15 g/L (p = 0.001), and severe cirrhosis, with a high Child Pugh C score or MELD score >20 (p = 0.001). Conclusion: SAFI was common in cirrhotic patients in the department. Certain clinical and paraclinical factors were associated with it, as was the severity of cirrhosis. Early diagnosis and aetiological management of cirrhosis could reduce its frequency.

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Viral Hepatitis C during a Screening Campaign in General Population of Benin: Seroprevalence and Associated Factors

Paraïso¹,

Kpossou²,

Sokpon³

et al. 2021

OJEpi

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Introduction: Hepatitis C is a global public health problem. The purpose of this study was to determine the prevalence and factors associated with hepatitis C virus (HCV) antibody carriage during mass screening in several localities throughout Benin. Methods: This was a descriptive and analytical cross-sectional study with prospective data collection. This collection took place from 20 to 28 July 2019 at a free voluntary hepatitis C screening organized in Benin by Rotary Clubs in 23 sites throughout the country. A rapid diagnostic orientation test was used for the detection of anti-HCV antibodies. Results: A total of 9035 voluntary participants were included, mostly of Beninese nationality (99.0%), with a median age of 27 years, of whom 51.1% (4619/9035) were single and mainly schoolchildren, pupils or students (37.9%; 3426/9035). HCV seroprevalence was 1.0% (87/9035) [95% CI = 0.8% -1.2%]. This infection was associated with age greater than 42 years (ORa = 2.71; 95% CI: 1.06 -6.95), p < 0.03, and history of diabetes (ORa = 3.9; 95% CI: 1.9 -7.6). Conclusion: HCV antibody seroprevalence is relatively low in the study population: 1%. Factors associated with HCV antibody carriage were age, occupation and diabetic history.

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Infection par le virus de l’hépatite C chez les patients diabétiques traités au CHU Gabriel Touré et au Centre de lutte contre le diabète de Bamako (Mali)

Cited by 5 publications

References 13 publications

Seroprevalence and Molecular Biodiverisity of Hepatitis C Infection in Congolese Diabetics

Seroprevalence and Molecular Biodiverisity of Hepatitis C Infection in Congolese Diabetics

Spontaneous Infection of Ascites Fluid at the National and University Hospital Hubert Koutoukou Maga in Cotonou: Prevalence and Associated Factors

Viral Hepatitis C during a Screening Campaign in General Population of Benin: Seroprevalence and Associated Factors

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