Infection of peripheral blood mononuclear cells by hepatitis C virus in mixed cryoglobulinemia

Ferri, Cássia; Monti, Monica; Civita, L. La; Longombardo, G.; Greco, Fulvia; Pasero, G; Geñtilini, Paolo; Bombardieri, Stefano; Zignego, A.L.

doi:10.1182/blood.v82.12.3701.3701

Cited by 251 publications

(108 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several studies from different patient populations [33,57] reported a strong association between mixed cryoglobulinaemia and HCV infection, varying from 80% to 90% of cases. Moreover, the presence of viral replication (negative-stranded viral RNA) in the peripheral lymphocytes, bone marrows and lymph nodes from mixed cryoglobulinaemia patients, with or without complicating NHL, reinforces the hypothesis of a possible causative role of HCV in this disorder [34,[36][37][38]42].…”

Section: Hcv and Cancer 713mentioning

confidence: 59%

“…Table 2 summarizes the main extrahepatic manifestations that can be associated with chronic HCV infection: they are immune-mediated and/or lymphoproliferative disorders. As HCV is both a hepato-and lymphotropic virus [36][37][38], it is likely that HCV infection of T-and B-lymphocytes could at least, in part, be responsible for these disorders often observed in chronically infected individuals. HCV, alone or in combination with other factors, i.e.…”

Section: Chronic Hcv Infectionmentioning

confidence: 99%

“…HCV and cancer Figure 1 shows the network of events intervening between chronic HCV infection and some correlated malignancies. According to the above-mentioned lympho-and hepatotropism [36][37][38]47] (Fig. 1a and b), HCV may exert its oncogenic potential in two different directions, leading to B-cell neoplasias and liver cancer respectively.…”

Section: Chronic Hcv Infectionmentioning

confidence: 99%

See 2 more Smart Citations

Viruses and cancers: possible role of hepatitis C virus

Ferri

Civita

Zignego

et al. 1997

Eur J Clin Investigation

View full text Add to dashboard Cite

Abstract. Oncogenesis is a multifactorial process in which environmental, genetic and infectious factors are variably involved. A possible role of specific viruses has been suggested in at least 15% of human cancers. Hepatitis C virus (HCV), which is both hepato-and lymphotropic, is responsible for various liver disorders, i.e. chronic hepatitis, cirrhosis and hepatocellular carcinoma, as well as for a constellation of extrahepatic immune-mediated manifestations, among which is mixed cryoglobulinaemia. This is a systemic disorder secondary to a chronic, benign B-lymphocyte proliferation, which in some subjects may evolve to a malignant non-Hodgkin's lymphoma (NHL). Interestingly, recent studies reported the appearance of malignant B-cell neoplasias in patients with type C chronic hepatitis; moreover, in a significant number (from 22% to 50%) of 'idiopathic' NHLs, the presence of HCV infection has been demonstrated. The presence of a geographical etherogeneity in the prevalence of HCV-positive NHL suggests that other co-factors, i.e. genetic and environmental, could be involved in the lymphomagenesis. HCV may exert its oncogenic potential in two different directions, leading to liver cancer or B-cell lymphoma.

show abstract

Section: Hcv and Cancer 713mentioning

confidence: 59%

Section: Chronic Hcv Infectionmentioning

confidence: 99%

Section: Chronic Hcv Infectionmentioning

confidence: 99%

See 1 more Smart Citation

Viruses and cancers: possible role of hepatitis C virus

Ferri

Civita

Zignego

et al. 1997

Eur J Clin Investigation

View full text Add to dashboard Cite

show abstract

“…Clinical and serological studies have emphasized a possible etiological role of different viral infections [6][7][8], although the specificity of primary IgG is still unclear and understanding of the early, pathogenic steps is currently slight. Recently, the finding of antibodies to the hepatitis C virus (HCV) [9][10][11][12][13] and of HCV-RNA sequences in the sera [12][13][14][15] and in mononuclear cells [16,17] of a large proportion of patients with MC suggested that HCV may be relevant to the onset and/or development of this disorder. However, it is not clear whether the appearance of cryoglobulinaemia is related to antibodies directed against a defined antigenic region; similarly, comparative analysis of the response to specific HCV epitopes in HCV-infected patients with (MC ) and without (MC ÿ ) cryoglobulinaemia is necessary.…”

Section: Introductionmentioning

confidence: 99%

Differential humoral immune response against hepatitis C virus antigenic synthetic peptides in infected patients with and without mixed cryoglobulinaemia

Gabrielli

Zhang

Cherubini

et al. 1996

Clinical and Experimental Immunology

View full text Add to dashboard Cite

SUMMARYIn this study we have evaluated the prevalence of antibodies against core region peptides (residues 1-28, 21-38 and 51-68), the envelope 1, the non-structural (NS) 4 and 5 proteins of hepatitis C virus (HCV) in sera from 65 chronically HCV-infected patients, 47 with mixed cryoglobulinaemia (MC ) and 18 without (MC ÿ ). The major binding sites were located within the core region. Regions 1-28 and 51-68 were recognized by a similar proportion of MC and MC ÿ patients, while peptide 21-38 was less frequently detected by samples from MC patients (65 . 5% versus 100%; P 0 . 011). The patterns of the reactions showed a minimum of three binding sites: one, located within region 51-68, was shared by both groups; a second determinant was identified at residues 1-21 for MC patients and at residues 28-38 for MC ÿ patients; a third, not exactly localized, lay between residues 1 and 38. Recognition of NS5 peptides was not significantly different between MC and MC ÿ patients, but while the former mostly reacted either with peptide 1 (residues 2294-2309) (five of 15 sera) or with peptide 2 (residues 2304-2319) (nine of 15 sera), the latter group showed a more scattered reaction. Antibodies to HCV peptides prevalently belonged to IgG1 subclass. However, whereas IgG1 antibodies against peptide 21-38 and peptide 1 of NS5 were more frequently found in MC ÿ rather than in MC patients (100% versus 63 . 8%, P 0 . 003, and 22 . 2% versus 4 . 2%, P 0 . 025, respectively), IgG3 antibodies against region 1-28 were more frequent in MC patients (53 . 19% versus 16 . 6%, P 0 . 0078). Overall, the data suggest that a differential humoral immune response to HCV antigens occurs in patients with and without cryoglobulinaemia.

show abstract

“…A major pathogenetic role of hepatitis C virus (HCV) infection in the occurrence of mixed cryoglobulinaemia (MC) type II is now well documented (Ferri et al, 1993). Recently, anti-HCV antibodies and viral sequences have been observed in a substantial number of patients with non-Hodgkin's lymphoma not associated with cryoglobulinaemia, extending the spectrum of lymphoid disorders possibly related to HCV (Ferri et al, 1994).…”

mentioning

confidence: 99%

Additional neoplasms and HCV infection in low‐grade lymphoma of MALT type

et al. 1996

View full text Add to dashboard Cite

Several chronic inflammatory conditions and genetic alterations are likely to be involved in the pathogenesis of low-grade lymphoma of MALT type. In a well-characterized series of 27 patients with low-grade lymphoma of MALT type, we studied: (1) the incidence of other neoplasms, which might be indicative of genetic instability, apparently a characteristic of this disease; (2) the prevalence of serologic and molecular markers of HCV infection, which has been found in association with other lymphoproliferative disorders. Three patients had one or more additional cancers; a total of eight tumours, five of which occurred in the same patient, suggests the presence of some genetic instability in at least some cases of the disease. Rather unexpectedly, anti-HCV antibodies and HCV RNA sequences were documented in 50% of the patients examined, without elevation of serum transaminases. Of interest, the two patients with parotid and conjunctival MALT lymphomas, respectively, with a previous history of Sjögren's syndrome, were HCV positive. We suggest, for the first time, that HCV may be considered, in addition to Helicobacter pylori, as another potential infectious co-factor in the multistep pathogenesis of low-grade lymphomas of MALT type.

show abstract

Infection of peripheral blood mononuclear cells by hepatitis C virus in mixed cryoglobulinemia

Cited by 251 publications

References 0 publications

Viruses and cancers: possible role of hepatitis C virus

Viruses and cancers: possible role of hepatitis C virus

Differential humoral immune response against hepatitis C virus antigenic synthetic peptides in infected patients with and without mixed cryoglobulinaemia

Additional neoplasms and HCV infection in low‐grade lymphoma of MALT type

Contact Info

Product

Resources

About