Infection of normal C3H/HeN mice with Taenia saginata asiatica oncospheres

Peng, Shih-Yi; Chu, Tzu-Hui; Wang, I-Chuang; Chung, W. C.; Yu, K. W.; Tsaihong, John Chin; Huang, Jason C.; Fan, P. C.

doi:10.1016/j.rvsc.2008.07.009

Cited by 9 publications

(5 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since the level of neutralizing antibody production has been reported to be associated with the intensity of IFNγ induction in lymph nodes [ 41 ], the higher neutralizing antibody production in CTRs may be explained by the marginally higher IFNγ transcription in the draining PLNs of the CTRs compared to the NZWRs especially on day 7 pi ( Figure 5 G,H,I). Furthermore, upregulated IFNγ expression in the spleen and the CNS has been reported to be associated with peripheral parasitic infection in mice [ 42 , 43 ]. Potential background parasitic infection in feral CTRs may, therefore, play an important role in shaping the IFNγ and the associated neutralizing antibody response in flavivirus-challenged feral rabbits.…”

Section: Discussionmentioning

confidence: 99%

Experimental West Nile Virus Infection in Rabbits: An Alternative Model for Studying Induction of Disease and Virus Control

et al. 2015

View full text Add to dashboard Cite

The economic impact of non-lethal human and equine West Nile virus (WNV) disease is substantial, since it is the most common presentation of the infection. Experimental infection with virulent WNV strains in the mouse and hamster models frequently results in severe neural infection and moderate to high mortality, both of which are not representative features of most human and equine infections. We have established a rabbit model for investigating pathogenesis and immune response of non-lethal WNV infection. Two species of rabbits, New Zealand White (Oryctolagus cuniculus) and North American cottontail (Sylvilagus sp.), were experimentally infected with virulent WNV and Murray Valley encephalitis virus strains. Infected rabbits exhibited a consistently resistant phenotype, with evidence of low viremia, minimal-absent neural infection, mild-moderate neuropathology, and the lack of mortality, even though productive virus replication occurred in the draining lymph node. The kinetics of anti-WNV neutralizing antibody response was comparable to that commonly seen in infected horses and humans. This may be explained by the early IFNα/β and/or γ response evident in the draining popliteal lymph node. Given this similarity to the human and equine disease, immunocompetent rabbits are, therefore, a valuable animal model for investigating various aspects of non-lethal WNV infections.

show abstract

Section: Discussionmentioning

confidence: 99%

Experimental West Nile Virus Infection in Rabbits: An Alternative Model for Studying Induction of Disease and Virus Control

et al. 2015

View full text Add to dashboard Cite

show abstract

“…s . asiatica , C3H/HeN mice had the highest cysticerci recovery rate compared to the BALB/CAnN and C57BL/6N mice [ 27 ]. In the study conducted by [ 49 ] Fan et al .…”

Section: 0 Resultsmentioning

confidence: 99%

Experimental animal models and their use in understanding cysticercosis: A systematic review

et al. 2022

View full text Add to dashboard Cite

BackgroundCysticercosis and Neurocysticercosis (NCC) can be studied using several animal species in experimental models which contributes to the understanding of the human form of the disease. Experimental infections ofTaeniaspp. are vital in explaining the modes of transmission of the parasite and helps the understanding of transmission of the parasite in humans and thus may be useful in designing therapeutic and immune-prophylactic studies to combat the disease. Thus, this systematic review aims to explore the existing experimental animal models to the understanding of cysticercosis in both humans and animals and elucidate the risk factors of cysticercosis and identify theTaeniaspp. used in these models.MethodologyWe systematically identified all publications from the Web of Science, Google Scholar, and Pubmed regarding experimental animal models usingTaeniaspp. that cause cysticercosis in both humans and animals. 58 studies were identified for eligibility. Of these, only 48 studies met the inclusion criteria from which data extraction was done and presented descriptively.ResultsPigs, cattle, gerbils, mice, rats, voles, monkeys, cats, dogs, and goats were used in whichT.solium,T.saginata,T.saginata asiatica,T.crassicepsandT.asiaticawere studied. The routes used to induce disease were; oral, intravenous, subcutaneous, intramuscular, intraperitoneal, intraarterial, intracranial, intraduodenal, and surgical routes using eggs, oncospheres, and proglottids. Besides, the establishment of infection using eggs and oncospheres was affected by the route used to induce infection in the experimental animals. The cysticerci recovery rate in all the experimental studies was low and the number of animals used in these experiments varied from 1 to 84. Although not analysed statistically, sex, age, and breed of animals influenced the cysticerci recovery rate. Additionally, the cysticerci recovery rate and antibody-antigen levels were shown to increase with an increase in the dose of oncospheres and eggs inoculated in the animals. Contrasting results were reported in which the cysticerci recovery rate decreased with an increase in the dose of eggs inoculated.ConclusionThis review describes the various animal experiments usingTaenia speciesthat cause cysticercosis highlighting the animals used, age and their breed, the routes of infection used to induce disease and the sample size used, and the cysticerci recovery rate in these animal models.

show abstract

“…Therefore, natural killer cells, macrophages or complements may have some essential innate resistant to these cestodes' establishment and growth in resistant host animals. Recent study using normal C3H/HeN female mice revealed that in vitro ‐hatched (but not clear exactly activated or not) oncospheres injected subcutaneously could develop much bigger cysticerci than those developed in pigs . Oncosphere activation by bile salt is essential per oral egg inoculation, but subcutaneous or peritoneal injection or injection into the brain of just hatched but not activated oncospheres develop into cysticerci .…”

Section: Topicsmentioning

confidence: 99%

Basic and applied problems in developmental biology and immunobiology of cestode infections: Hymenolepis,Taenia and Echinococcus

Itō

2015

Parasite Immunology

View full text Add to dashboard Cite

Differentiation and development of parasites, including longevity in host animals, are thought to be governed by host-parasite interactions. In this review, several topics on the developmental biology of cestode infections are discussed from immunobiological perspective with a focus on Hymenolepis, Taenia and Echinococcus infections. The basic premise of this review is that 'differentiation and development of cestodes' are somehow affected by host immune responses with an evolutionary history.

show abstract

Infection of normal C3H/HeN mice with Taenia saginata asiatica oncospheres

Cited by 9 publications

References 29 publications

Experimental West Nile Virus Infection in Rabbits: An Alternative Model for Studying Induction of Disease and Virus Control

Experimental West Nile Virus Infection in Rabbits: An Alternative Model for Studying Induction of Disease and Virus Control

Experimental animal models and their use in understanding cysticercosis: A systematic review

Basic and applied problems in developmental biology and immunobiology of cestode infections: Hymenolepis,Taenia and Echinococcus

Contact Info

Product

Resources

About