Infection of hepatitis B virus in extrahepatic endothelial tissues mediated by endothelial progenitor cells

Rong, Qi-fei; Huang, Jun; Su, Enben; Li, Jun; Li, Jianyong; Zhang, Lili; Cao, Kejiang

doi:10.1186/1743-422x-4-36

Cited by 28 publications

(31 citation statements)

References 45 publications

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“…dermatological disease, arthritis, glomerulonephritis, aplastic anaemia, neuropathy, vasculitis, myocarditis), and the virus has extensive reservoirs of extra-hepatic replication (e.g. lymph nodes, spleen, bone marrow, kidney, colon, stomach, skin, pancreas, brain, heart, lung) [Rong et al, 2007]. It is therefore conceivable that chronic HBV infection could upregulate the expression of hypoxia-inducible genes even in tissues other than the liver.…”

Section: Hbx Regulation Of Ca IX Expression In Human Hepatocellular Cmentioning

confidence: 99%

Role of the HBx oncoprotein in carbonic anhydrase 9 induction

Holotnakova¹,

Tylková²,

Takáčová³

et al. 2009

Journal of Medical Virology

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International audienceCarbonic anhydrase 9 (CA9), as one of the most hypoxia-responsive genes, has been associated almost exclusively with hypoxic tumours. Its principal role is in pH regulation which helps tumour cells overcome intracellular acidosis and survive extended periods of time with low oxygen. Hypoxia-inducible factor 1 (HIF-1) is the main transcriptional activator of CA9. Hepatitis B virus X protein (HBx) has been shown to increase the transcriptional activity of HIF-1. HBx is often expressed from the gene integrated in the hepatocytes infected persistently and contributes significantly to alterations in host gene expression that can lead to the development of hepatocellular carcinoma (HCC) associated with HBV. The aim of this study was to determine the effect of HBx on expression of CA9. Transient transfection of HBx led to an increase in the expression of CA9 as assessed by RT-PCR and Western blotting. HBx was able to increase CA9 promoter activity significantly in several cell lines. The effect was mediated via HIF-1 and a functional HRE element located –10/–3 bp upstream of the CA9 transcription initiation site. These data suggest that CA9 may be involved in the development of HCC by contributing to the survival of hepatocytes infected with HBV in liver tissue with fibrosis

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Section: Hbx Regulation Of Ca IX Expression In Human Hepatocellular Cmentioning

confidence: 99%

Role of the HBx oncoprotein in carbonic anhydrase 9 induction

Holotnakova¹,

Tylková²,

Takáčová³

et al. 2009

Journal of Medical Virology

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“…Our previous study has showed that the EPCs derived from cord blood are capable of uptaking HBV, but not support the viral replication [16]. It is totally unknown whether MSCs are capable of uptaking HBV or permissive for HBV replication.…”

Section: Introductionmentioning

confidence: 99%

Bone marrow‐derived mesenchymal stem cells are capable of mediating hepatitis B virus infection in injured tissues

Rong

Zhang²,

Su³

et al. 2008

Journal of Viral Hepatitis

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“…There are two hypotheses regarding HBV related myocarditis; one proposes an indirect mechanism with immune complexes (12), whereas the other proposes a direct myocardial cell injury by HBV. Some authors have reported that HBV proteins and nucleic acids were found in a number of non-hepatic tissues, including the myocardium (11,13). However, the acute heart failure in the present case was not myocarditis but myopathy because the serum levels of CK, which is a sensi- Figure 4.…”

Section: Discussionmentioning

confidence: 99%

Acute Liver Failure Complicated with Severe Heart Failure

et al. 2015

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A young pregnant woman was hospitalized due to hepatitis B virus (HBV)-related acute liver failure (ALF). The cardiac function was normal on admission. However, she developed ALF concurrently with a coma and severe cardiac failure. The patient was diagnosed with severe acute cardiomyopathy due to diffuse hypokinesis of the left ventricle wall on ultrasound cardiography. Following intensive treatment, both the liver and cardiac function dramatically recovered. Although some factors, such as HBV, pregnancy and systemic inflammatory response syndrome, are possible causes of acute cardiomyopathy in the present case, ALF itself may be a risk factor for heart failure.

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Infection of hepatitis B virus in extrahepatic endothelial tissues mediated by endothelial progenitor cells

Abstract: Background: Hepatitis B virus (HBV) replication has been reported to be involved in many extrahepatic viral disorders; however, the mechanism by which HBV is trans-infected into extrahepatic tissues such as HBV associated myocarditis remains largely unknown.

Cited by 28 publications

References 45 publications

Role of the HBx oncoprotein in carbonic anhydrase 9 induction

Role of the HBx oncoprotein in carbonic anhydrase 9 induction

Bone marrow‐derived mesenchymal stem cells are capable of mediating hepatitis B virus infection in injured tissues

Acute Liver Failure Complicated with Severe Heart Failure

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