Infection in the Renal and Liver Transplant Patient

Rubin, Robert H.

doi:10.1007/978-1-4615-6642-7_21

Cited by 33 publications

(45 citation statements)

References 341 publications

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“…CMV infection contributes significantly to the morbidity and mortality after renal allograft transplant [3]. Acute interstitial nephritis is a well-recognized feature of the congenital and neonatal CMV infection [4], however, it is rarely reported in adults.…”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus-Induced Tubulointerstitial Nephritis in a Renal Allograft Treated by Foscarnet Therapy

Wong

Chan²,

Chan³

et al. 2000

Am J Nephrol

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We report a female patient suffering from cytomegalovirus (CMV)-induced tubulointerstitial nephritis in a renal allograft 70 days after a cadaveric renal transplantation. CMV-induced renal allograft injury reported in the literature mainly related to immune-mediated mechanisms. In our patient, acute tubulointerstitial nephritis, associated with histological evidence of CMV infection, was demonstrated in the renal allograft biopsy. There were no histological features of allograft rejection, cyclosporin nephrotoxicity nor ‘CMV glomerulopathy’. She was successfully treated by foscarnet therapy and a reduction in immunosuppression. Her renal function returned to baseline afterwards.

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Section: Discussionmentioning

confidence: 99%

Cytomegalovirus-Induced Tubulointerstitial Nephritis in a Renal Allograft Treated by Foscarnet Therapy

Wong

Chan²,

Chan³

et al. 2000

Am J Nephrol

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“…The impact of this differ ence on our conclusions is unclear. Whereas CS-A-based and azathioprine-based immunosuppressive regimens may be associated with similar rates of CMV infection when the use of antilymphocytic agents is excluded, the higher incidence of rejection associated with azathio prine-based regimens usually results in a higher rate of CMV infection in those patients because of the increased usage of antilymphocytic agents for control of rejection [30,31]. As discussed above, although the rate of rejection and use of antilymphocytic agents tended to be greater in the IvIgG-group, the differences were not significant.…”

Section: Discussionmentioning

confidence: 99%

Intravenous Immunoglobulin Prophylaxis of Cytomegalovirus Infection in Pediatric Renal Transplant Recipients

et al. 1997

Am J Nephrol

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Cytomegalovirus (CMV), the most significant infectious cause of morbidity following renal transplantation, may be a greater problem for children than for adults due to their relative lack of experience with this virus. Therefore, we prospectively gave Gammagard® as prophylaxis to CMV-negative children who received CMV-positive allografts and compared the results to our experience with similar high-risk recipients transplanted prior to our use of intravenous immunoglobulin G (IvIgG). Symptomatic CMV disease developed in 17% of the IvIgG recipients as compared with 71% of the untreated patients (p = 0.01). The CMV infections that did occur in IvIgG recipients developed significantly later than in untreated children (median time of onset after transplantation 2.60 vs. 1.35 months; p < 0.05) and generally were less severe, although 1 IvIgG recipient died despite prophylaxis. IvIgG administration did not affect the frequency of rejection or graft or patient survival. We conclude that IvIgG administration to high-risk pediatric renal transplant recipients may protect against posttransplantation CMV disease and may lessen the severity of infections that do develop in patients who receive it.

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“…In immunocompromised hosts, patients are at risk not only of postherpetic neuralgia but also of severe local dermatomal infection (Rubin & Tolkoff-Rubin, 1983). Similarly, immunosuppressed patients are at increased risk for the development of disseminated cutaneous zoster and visceral dissemination.…”

Section: Herpes Zoster Virus (Hzv) 2101 Uncomplicated Herpes Zostermentioning

confidence: 99%

Infectious Complications in Kidney Transplantation

El‐Husseini¹,

Hassan²

2011

After the Kidney Transplant - The Patients and Their Allograft

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Infection in the Renal and Liver Transplant Patient

Cited by 33 publications

References 341 publications

Cytomegalovirus-Induced Tubulointerstitial Nephritis in a Renal Allograft Treated by Foscarnet Therapy

Cytomegalovirus-Induced Tubulointerstitial Nephritis in a Renal Allograft Treated by Foscarnet Therapy

Intravenous Immunoglobulin Prophylaxis of Cytomegalovirus Infection in Pediatric Renal Transplant Recipients

Infectious Complications in Kidney Transplantation

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