Infection in Rhesus (Macaca mulatta) and Squirrel
(Saimiri sciureus) Monkeys due to Mycobacterium
tuberculosis Phage Type B

Mayhall, C. Glen; Lamb, V. A.; Coleman, Philip H.

doi:10.1159/000460094

Cited by 13 publications

(8 citation statements)

References 3 publications

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“…Regulatory T (T reg ) cells express CD4 + and CD25 + and have potent immune response suppressive activity [40]; however, their exact role in HTLV-1 infection is unknown. In recent studies, leukaemia cells from patients with ATLL strongly expressed FoxP3 [32], a specific marker for T reg cells.…”

Section: Discussionmentioning

confidence: 99%

Dynamic Interaction between STLV-1 Proviral Load and T-Cell Response during Chronic Infection and after Immunosuppression in Non-Human Primates

et al. 2009

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We used mandrills (Mandrillus sphinx) naturally infected with simian T-cell leukemia virus type 1 (STLV-1) as a model for evaluating the influence of natural STLV-1 infection on the dynamics and evolution of the immune system during chronic infection. Furthermore, in order to evaluate the role of the immune system in controlling the infection during latency, we induced immunosuppression in the infected monkeys. We first showed that the STLV-1 proviral load was higher in males than in females and increased significantly with the duration of infection: mandrills infected for 10–6 years had a significantly higher proviral load than those infected for 2–4 years. Curiously, this observation was associated with a clear reduction in CD4+ T-cell number with age. We also found that the percentage of CD4+ T cells co-expressing the activation marker HLA-DR and the mean percentage of CD25+ in CD4+ and CD8+ T cells were significantly higher in infected than in uninfected animals. Furthermore, the STLV-1 proviral load correlated positively with T-cell activation but not with the frequency of T cells secreting interferon γ in response to Tax peptides. Lastly, we showed that, during immunosuppression in infected monkeys, the percentages of CD8+ T cells expressing HLA-DR+ and of CD4+ T cells expressing the proliferation marker Ki67 decreased significantly, although the percentage of CD8+ T cells expressing HLA-DR+ and Ki67 increased significantly by the end of treatment. Interestingly, the proviral load increased significantly after immunosuppression in the monkey with the highest load. Our study demonstrates that mandrills naturally infected with STLV-1 could be a suitable model for studying the relations between host and virus. Further studies are needed to determine whether the different compartments of the immune response during infection induce the long latency by controlling viral replication over time. Such studies would provide important information for the development of immune-based therapeutic strategies.

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Section: Discussionmentioning

confidence: 99%

Dynamic Interaction between STLV-1 Proviral Load and T-Cell Response during Chronic Infection and after Immunosuppression in Non-Human Primates

et al. 2009

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“…Outbreaks in both feral (Keet et al 2000;Michel et al 2013) and captive (Schroeder 1938;Benson et al 1955;Mayhall et al 1981;Fourie and Odendaal 1983;Shin et al 1995;Panarella and Bimes 2010;Payne et al 2011) colonies have been reported. All NHP species are considered potentially susceptible to M. tuberculosis infection (Good 1984), with a general susceptibility hierarchy of Old World species (most susceptible), followed by apes, and New World monkeys (least susceptible) (Montali et al 2001).…”

Section: Historical Use Of Nhps In Tb Researchmentioning

confidence: 99%

Modeling Tuberculosis in Nonhuman Primates

Scanga

Flynn

2014

Cold Spring Harbor Perspectives in Medicine

130

117

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Nonhuman primates have emerged as an excellent model of human tuberculosis, in large part because they recapitulate the full spectrum of infection outcome and pathology seen in humans. Several variables inherent to the nonhuman primate models of tuberculosis are discussed in this review, including the monkey species, Mycobacterium tuberculosis strains, and routes of infection, all of which can influence the model to be chosen for various studies. New technologies for studying the microbiology, immunology, and pathogenesis of tuberculosis in nonhuman primates have greatly expanded the capabilities of this model for basic and translational studies, including the development and testing of new treatment and prevention strategies for tuberculosis.

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“…144 Many similar scenarios have been reported and so underscore the difficulties inherent in screening for disease and containing the outbreak once an infected animal is identified. 47,64,93 Both New World and Old World species are susceptible. Most reports of mycobacteriosis in Old World animals involve rhesus and cynomolgus macaques, but African monkeys and great apes are susceptible as well.…”

Section: Tuberculosismentioning

confidence: 99%

REVIEW PAPER: Emerging and Reemerging Infectious Diseases of Nonhuman Primates in the Laboratory Setting

Bailey

Mansfield

2010

Vet Pathol

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Despite numerous advances in the diagnosis and control of infectious diseases of nonhuman primates in the laboratory setting, a number of infectious agents continue to plague colonies. Some, such as measles virus and Mycobacterium tuberculosis, cause sporadic outbreaks despite well-established biosecurity protocols, whereas others, such as retroperitoneal fibromatosis-associated herpesvirus, have only recently been discovered, often as a result of immunosuppressive experimental manipulation. Owing to the unique social housing requirements of nonhuman primates, importation of foreign-bred animals, and lack of antemortem diagnostic assays for many new diseases, elimination of these agents is often difficult or impractical. Recognition of these diseases is therefore essential because of their confounding effects on experimental data, impact on colony health, and potential for zoonotic transmission. This review summarizes the relevant pathology and pathogenesis of emerging and reemerging infectious diseases of laboratory nonhuman primates.

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Infection in Rhesus (Macaca mulatta) and Squirrel (Saimiri sciureus) Monkeys due to Mycobacterium tuberculosis Phage Type B

Cited by 13 publications

References 3 publications

Dynamic Interaction between STLV-1 Proviral Load and T-Cell Response during Chronic Infection and after Immunosuppression in Non-Human Primates

Dynamic Interaction between STLV-1 Proviral Load and T-Cell Response during Chronic Infection and after Immunosuppression in Non-Human Primates

Modeling Tuberculosis in Nonhuman Primates

REVIEW PAPER: Emerging and Reemerging Infectious Diseases of Nonhuman Primates in the Laboratory Setting

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